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Molecular dynamics (MD) simulations are useful in obtaining thermodynamic and kinetic properties of bio-molecules but are limited by the timescale barrier, i.e., we may be unable to efficiently obtain properties because we need to run…

化学物理 · 物理学 2017-08-23 Surl-Hee Ahn , Jay W. Grate , Eric F. Darve

Adaptive designs are increasingly used in clinical trials and online experiments to improve participant outcomes by dynamically updating treatment allocation as data accumulate. In practice, experimenters often consider multiple candidate…

统计方法学 · 统计学 2026-04-08 Wenxin Zhang , Aaron Hudson , Maya Petersen , Mark van der Laan

While a difference-in-differences (DID) design was originally developed with one pre- and one post-treatment period, data from additional pre-treatment periods are often available. How can researchers improve the DID design with such…

应用统计 · 统计学 2022-02-14 Naoki Egami , Soichiro Yamauchi

Large Language Model (LLM)-powered Multi-agent systems (MAS) have achieved state-of-the-art results on various complex reasoning tasks. Recent works have proposed techniques to automate the design of MASes, eliminating the need for manual…

人工智能 · 计算机科学 2026-05-20 Bohan Yao , Shiva Krishna Reddy Malay , Vikas Yadav

This paper investigates the role of high-dimensional information sets in the context of Markov switching models with time varying transition probabilities. Markov switching models are commonly employed in empirical macroeconomic research…

计量经济学 · 经济学 2019-05-07 Gregor Zens , Maximilian Böck

A multi-agent AI system (MAS) is composed of multiple autonomous agents that interact, exchange information, and make decisions based on internal generative models. Recent advances in large language models and tool-using agents have made…

Multi-arm motion planning is fundamental for enabling arms to complete complex long-horizon tasks in shared spaces efficiently but current methods struggle with scalability due to exponential state-space growth and reliance on large…

机器人学 · 计算机科学 2025-09-11 Viraj Parimi , Brian C. Williams

Recent research on formal verification for Collective Adaptive Systems (CAS) pushed advancements in spatial and spatio-temporal model checking, and as a side result provided novel image analysis methodologies, rooted in logical methods for…

计算机科学中的逻辑 · 计算机科学 2016-07-11 Gina Belmonte , Vincenzo Ciancia , Diego Latella , Mieke Massink

Inverse design has emerged as a transformative approach for photonic device optimization, enabling the exploration of high-dimensional, non-intuitive design spaces to create ultra-compact devices and advance photonic integrated circuits…

We introduce a novel class of factor analysis methodologies for the joint analysis of multiple studies. The goal is to separately identify and estimate 1) common factors shared across multiple studies, and 2) study-specific factors. We…

应用统计 · 统计学 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

The synthesis of energy systems is a two-stage optimization problem where design decisions have to be implemented here-and-now (first stage), while for the operation of installed components, we can wait-and-see (second stage). To identify a…

In computerized adaptive testing (CAT), items (questions) are selected in real time based on the already observed responses, so that the ability of the examinee can be estimated as accurately as possible. This is typically formulated as a…

统计理论 · 数学 2015-01-08 Shiyu Wang , Georgios Fellouris , Hua-Hua Chang

Group testing techniques are widely used in resource-constrained settings, such as infectious-disease screening, blood safety, DNA library screening, and industrial inspection, where the efficient use of limited testing resources depends…

统计方法学 · 统计学 2026-04-29 Chi-Kuang Yeh , Weng Kee Wong , Julie Zhou

Covariate-adjusted response-adaptive (CARA) designs have gained widespread adoption for their clear benefits in enhancing experimental efficiency and participant welfare. These designs dynamically adjust treatment allocations during interim…

统计方法学 · 统计学 2025-12-10 Xinwei Ma , Jingshen Wang , Waverly Wei

The Alternating Direction Method of Multipliers (ADMM) has gained a lot of attention for solving large-scale and objective-separable constrained optimization. However, the two-block variable structure of the ADMM still limits the practical…

最优化与控制 · 数学 2020-03-24 Kresimir Mihic , Mingxi Zhu , Yinyu Ye

Hybrid manufacturing (HM) technologies combine additive and subtractive manufacturing (AM/SM) capabilities in multi-modal process plans that leverage the strengths of each. Despite the growing interest in HM technologies, software tools for…

计算几何 · 计算机科学 2022-06-06 George P. Harabin , Morad Behandish

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

计算机视觉与模式识别 · 计算机科学 2025-11-04 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

It is crucial to design Phase II cancer clinical trials that balance the efficiency of treatment selection with clinical practicality. Sargent and Goldberg proposed a frequentist design that allow decision-making even when the primary…

统计方法学 · 统计学 2025-05-15 Moka Komaki , Satoru Shinoda , Haiyan Zheng , Kouji Yamamoto

Breakthroughs in cancer biology have defined new research programs emphasizing the development of therapies that target specific pathways in tumor cells. Innovations in clinical trial design have followed with master protocols defined by…

统计方法学 · 统计学 2020-07-09 Alexander M. Kaizer , Joseph S. Koopmeiners , Nan Chen , Brian P. Hobbs

Systematic differences in experimental materials, methods, measurements, and data handling between labs, over time, and among personnel can sabotage experimental reproducibility. Uncovering such differences can be difficult and time…

应用统计 · 统计学 2018-07-18 Bert Gunter
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