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Markov jump processes are continuous-time stochastic processes with a wide range of applications in both natural and social sciences. Despite their widespread use, inference in these models is highly non-trivial and typically proceeds via…

机器学习 · 计算机科学 2023-06-01 Patrick Seifner , Ramses J. Sanchez

We propose a unified framework that extends the inference methods for classical hidden Markov models to continuous settings, where both the hidden states and observations occur in continuous time. Two different settings are analyzed: hidden…

统计方法学 · 统计学 2021-06-18 Qingcan Wang , Weinan E

Switching dynamical systems provide a powerful, interpretable modeling framework for inference in time-series data in, e.g., the natural sciences or engineering applications. Since many areas, such as biology or discrete-event systems, are…

机器学习 · 计算机科学 2021-09-30 Lukas Köhs , Bastian Alt , Heinz Koeppl

We consider continuous time Markovian processes where populations of individual agents interact stochastically according to kinetic rules. Despite the increasing prominence of such models in fields ranging from biology to smart cities,…

机器学习 · 统计学 2016-05-16 Anastasis Georgoulas , Jane Hillston , Guido Sanguinetti

Piecewise-deterministic Markov processes (PDMPs) offer a powerful stochastic modeling framework that combines deterministic trajectories with random perturbations at random times. Estimating their local characteristics (particularly the…

统计方法学 · 统计学 2025-12-29 Romain Azaïs , Solune Denis

Spatio-temporal hidden Markov models are extremely difficult to estimate because their latent joint distributions are available only in trivial cases. In the estimation phase, these latent distributions are usually substituted with…

统计方法学 · 统计学 2025-09-19 Daniele Tancini , Riccardo Rastelli , Francesco Bartolucci

The estimation of absorption time distributions of Markov jump processes is an important task in various branches of statistics and applied probability. While the time-homogeneous case is classic, the time-inhomogeneous case has recently…

统计理论 · 数学 2022-07-26 Jamaal Ahmad , Martin Bladt , Mogens Bladt

In this paper we consider the problem of parameter inference for Markov jump process (MJP) representations of stochastic kinetic models. Since transition probabilities are intractable for most processes of interest yet forward simulation is…

统计计算 · 统计学 2014-09-16 Andrew Golightly , Darren J. Wilkinson

Many probabilistic inference problems such as stochastic filtering or the computation of rare event probabilities require model analysis under initial and terminal constraints. We propose a solution to this bridging problem for the widely…

系统与控制 · 电气工程与系统科学 2021-05-28 Michael Backenköhler , Luca Bortolussi , Gerrit Großmann , Verena Wolf

Advances in sampling schemes for Markov jump processes have recently enabled multiple inferential tasks. However, in statistical and machine learning applications, we often require that these continuous-time models find support on…

统计计算 · 统计学 2018-06-08 Iker Perez , Lax Chan , Mercedes Torres Torres , James Goulding , Theodore Kypraios

Biochemical reaction networks are an amalgamation of reactions where each reaction represents the interaction of different species. Generally, these networks exhibit a multi-scale behavior caused by the high variability in reaction rates…

定量方法 · 定量生物学 2023-04-14 Derya Altıntan , Bastian Alt , Heinz Koeppl

Bayesian analysis for Markov jump processes is a non-trivial and challenging problem. Although exact inference is theoretically possible, it is computationally demanding thus its applicability is limited to a small class of problems. In…

统计计算 · 统计学 2017-02-08 Vassilios Stathopoulos , Mark A. Girolami

We consider the inverse problem of reconstructing the posterior measure over the trajec- tories of a diffusion process from discrete time observations and continuous time constraints. We cast the problem in a Bayesian framework and derive…

机器学习 · 统计学 2016-12-21 Botond Cseke , David Schnoerr , Manfred Opper , Guido Sanguinetti

We develop the first exact Bayesian methodology for the problem of inference in discretely observed regime switching diffusions. Switching diffusion models extend ordinary diffusions by allowing for jumps in instantaneous drift and…

Predictability of behavior has emerged an an important characteristic in many fields including biology, medicine, and marketing. Behavior can be recorded as a sequence of actions performed by an individual over a given time period. This…

统计方法学 · 统计学 2017-11-13 Brian Vegetabile , Jenny Molet , Tallie Z. Baram , Hal Stern

Diffusive approximations of Markov jump processes often fail to accurately capture large fluctuations. This is confounding, as the rare events triggered by these large fluctuations, such as the failure of electronic memories, are often the…

介观与纳米尺度物理 · 物理学 2025-12-17 David Roberts , Trevor McCourt , Geremia Massarelli , Jeremy Rothschild , Nahuel Freitas

We estimate a general mixture of Markov jump processes. The key novel feature of the proposed mixture is that the transition intensity matrices of the Markov processes comprising the mixture are entirely unconstrained. The Markov processes…

统计方法学 · 统计学 2022-04-12 Halina Frydman , Budhi Surya

We consider a general method for the approximation of the distribution of a process conditioned to not hit a given set. Existing methods are based on particle system that are failable, in the sense that, in many situations , they are not…

概率论 · 数学 2016-06-30 William Oçafrain , Denis Villemonais

We present a learning model predictive control (MPC) scheme for chance-constrained Markov jump systems with unknown switching probabilities. Using samples of the underlying Markov chain, ambiguity sets of transition probabilities are…

最优化与控制 · 数学 2023-01-06 Mathijs Schuurmans , Panagiotis Patrinos

Markov jump process models have many applications across science. Often, these models are defined on a state-space of product form and only one of the components of the process is of direct interest. In this paper, we extend the marginal…

定量方法 · 定量生物学 2018-06-28 Leo Bronstein , Heinz Koeppl
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