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Calibrating mathematical models of biological processes is essential for achieving predictive accuracy and gaining mechanistic insight. However, this task remains challenging due to limited and noisy data, significant biological…

定量方法 · 定量生物学 2025-12-04 Piotr Gwiazda , Alexey Kazarnikov , Anna Marciniak-Czochra , Zuzanna Szymańska

Simulation models of critical systems often have parameters that need to be calibrated using observed data. For expensive simulation models, calibration is done using an emulator of the simulation model built on simulation output at…

统计方法学 · 统计学 2023-08-24 Özge Sürer , Matthew Plumlee , Stefan M. Wild

Calibration or parameter identification is used with computational mechanics models related to observed data of the modeled process to find model parameters such that good similarity between model prediction and observation is achieved. We…

计算工程、金融与科学 · 计算机科学 2022-12-26 Harald Willmann , Jonas Nitzler , Sebastian Brandstaeter , Wolfgang A. Wall

Computer models, aiming at simulating a complex real system, are often calibrated in the light of data to improve performance. Standard calibration methods assume that the optimal values of calibration parameters are invariant to the model…

统计方法学 · 统计学 2017-09-01 Georgios Karagiannis , Bledar A. Konomi , Guang Lin

In the context of computer models, calibration is the process of estimating unknown simulator parameters from observational data. Calibration is variously referred to as model fitting, parameter estimation/inference, an inverse problem, and…

统计方法学 · 统计学 2023-10-16 Richard D. Wilkinson , Christopher W. Lanyon

This paper proposes a novel fixed inducing points online Bayesian calibration (FIPO-BC) algorithm to efficiently learn the model parameters using a benchmark database. The standard Bayesian calibration (STD-BC) algorithm provides a…

计算物理 · 物理学 2021-03-17 Yu Duan , Matthew Eaton , Michael Bluck

Mixture model-based clustering has become an increasingly popular data analysis technique since its introduction over fifty years ago, and is now commonly utilized within a family setting. Families of mixture models arise when the component…

统计方法学 · 统计学 2019-11-11 Sanjeena Subedi , Paul D. McNicholas

A set of probabilistic predictions is well calibrated if the events that are predicted to occur with probability p do in fact occur about p fraction of the time. Well calibrated predictions are particularly important when machine learning…

机器学习 · 统计学 2014-01-14 Mahdi Pakdaman Naeini , Gregory F. Cooper , Milos Hauskrecht

Bayesian calibration of computer models tunes unknown input parameters by comparing outputs with observations. For model outputs that are distributed over space, this becomes computationally expensive because of the output size. To overcome…

统计方法学 · 统计学 2018-10-05 Kai-Lan Chang , Serge Guillas

Particle-in-Cell (PIC) methods are widely used computational tools for fluid and kinetic plasma modeling. While both the fluid and kinetic PIC approaches have been successfully used to target either kinetic or fluid simulations, little was…

In the drug discovery process, where experiments can be costly and time-consuming, computational models that predict drug-target interactions are valuable tools to accelerate the development of new therapeutic agents. Estimating the…

机器学习 · 计算机科学 2024-07-22 Hannah Rosa Friesacher , Ola Engkvist , Lewis Mervin , Yves Moreau , Adam Arany

This paper considers the computer model calibration problem and provides a general frequentist solution. Under the proposed framework, the data model is semi-parametric with a nonparametric discrepancy function which accounts for any…

统计方法学 · 统计学 2015-09-14 Raymond K. W. Wong , Curtis B. Storlie , Thomas C. M. Lee

Pattern formation in biological tissues plays an important role in the development of living organisms. Since the classical work of Alan Turing, a pre-eminent way of modelling has been through reaction-diffusion mechanisms. More recently,…

偏微分方程分析 · 数学 2023-01-27 Alexey Kazarnikov , Robert Scheichl , Heikki Haario , Anna Marciniak-Czochra

Ordinary differential equation models are nowadays widely used for the mechanistic description of biological processes and their temporal evolution. These models typically have many unknown and non-measurable parameters, which have to be…

定量方法 · 定量生物学 2021-05-27 Alejandro F. Villaverde , Dilan Pathirana , Fabian Fröhlich , Jan Hasenauer , Julio R. Banga

The empirical and particle force-based models of granular segregation due to density differences among the species are compared in this work. Dependency of the empirical segregation parameters on the initial configuration, the observation…

软凝聚态物质 · 物理学 2023-10-20 Soniya Kumawat , Vishnu Kumar Sahu , Anurag Tripathi

Bayesian calibration of black-box computer models offers an established framework to obtain a posterior distribution over model parameters. Traditional Bayesian calibration involves the emulation of the computer model and an additive model…

机器学习 · 统计学 2018-10-30 Sébastien Marmin , Maurizio Filippone

Calibration of computer models is a key step in making inferences, predictions, and decisions for complex science and engineering systems. We formulate and analyze a nonparametric Bayesian methodology for computer model calibration. This…

统计方法学 · 统计学 2025-12-01 Haiyi Shi , Lei Yang , Jiarui Chi , Troy Butler , Haonan Wang , Derek Bingham , Don Estep

Determining how to appropriately select the tuning parameter is essential in penalized likelihood methods for high-dimensional data analysis. We examine this problem in the setting of penalized likelihood methods for generalized linear…

统计方法学 · 统计学 2016-05-12 Yingying Fan , Cheng Yong Tang

This study aims to investigate the utilization of Bayesian techniques for the calibration of micro-electro-mechanical systems (MEMS) accelerometers. These devices have garnered substantial interest in various practical applications and…

信号处理 · 电气工程与系统科学 2023-06-13 Oliver Dürr , Po-Yu Fan , Zong-Xian Yin

For linear models with a diverging number of parameters, it has recently been shown that modified versions of Bayesian information criterion (BIC) can identify the true model consistently. However, in many cases there is little…

统计方法学 · 统计学 2011-07-26 Heng Lian
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