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Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

图像与视频处理 · 电气工程与系统科学 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

Autofluorescence lifetime images reveal unique characteristics of endogenous fluorescence in biological samples. Comprehensive understanding and clinical diagnosis rely on co-registration with the gold standard, histology images, which is…

图像与视频处理 · 电气工程与系统科学 2022-02-17 Qiang Wang , Susan Fernandes , Gareth O. S. Williams , Neil Finlayson , Ahsan R. Akram , Kevin Dhaliwal , James R. Hopgood , Marta Vallejo

Scarcity of labeled histopathology data limits the applicability of deep learning methods to under-profiled cancer types and labels. Transfer learning allows researchers to overcome the limitations of small datasets by pre-training machine…

计算机视觉与模式识别 · 计算机科学 2022-04-21 Anna Yeaton , Rahul G. Krishnan , Rebecca Mieloszyk , David Alvarez-Melis , Grace Huynh

Pathological features are the gold standard for tumor diagnosis, guiding treatment and prognosis. However, standard histopathological process is labor-intensive and time-consuming, while frozen sections have lower accuracy. Dynamic…

Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology…

Histopathology whole slide images (WSIs) are being widely used to develop deep learning-based diagnostic solutions, especially for precision oncology. Most of these diagnostic softwares are vulnerable to biases and impurities in the…

图像与视频处理 · 电气工程与系统科学 2024-10-01 Abhijeet Patil , Harsh Diwakar , Jay Sawant , Nikhil Cherian Kurian , Subhash Yadav , Swapnil Rane , Tripti Bameta , Amit Sethi

In recent years, histopathology images have been increasingly used as a diagnostic tool in the medical field. The process of accurately diagnosing a biopsy sample requires significant expertise in the field, and as such can be…

图像与视频处理 · 电气工程与系统科学 2019-09-24 Alison K. Cheeseman , Hamid Tizhoosh , Edward R. Vrscay

Histopathology is critical for the diagnosis of many diseases, including cancer. These protocols typically require pathologists to manually evaluate slides under a microscope, which is time-consuming and subjective, leading to interest in…

计算机视觉与模式识别 · 计算机科学 2023-03-07 Kianoush Falahkheirkhah , Alex Lu , David Alvarez-Melis , Grace Huynh

Processing histopathological Whole Slide Images (WSI) leads to massive storage requirements for clinics worldwide. Even after lossy image compression during image acquisition, additional lossy compression is frequently possible without…

Computational pathology has made significant progress in recent years, fueling advances in both fundamental disease understanding and clinically ready tools. This evolution is driven by the availability of large amounts of digitized slides…

Chemical staining methods are dependable but require extensive time, expensive chemicals, and raise environmental concerns. These challenges highlight the need for alternative solutions like virtual staining, which accelerates the…

图像与视频处理 · 电气工程与系统科学 2024-07-02 Mehdi Ounissi , Ilias Sarbout , Jean-Pierre Hugot , Christine Martinez-Vinson , Dominique Berrebi , Daniel Racoceanu

Compared to hematoxylin-eosin (H&E) staining, immunohistochemistry (IHC) not only maintains the structural features of tissue samples, but also provides high-resolution protein localization, which is essential for aiding in pathology…

计算机视觉与模式识别 · 计算机科学 2025-11-04 Yuhang Kang , Ziyu Su , Tianyang Wang , Zaibo Li , Wei Chen , Muhammad Khalid Khan Niazi

Due to recent advances in technology, digitized histopathology images are now widely available for both clinical and research purposes. Accordingly, research into computerized image analysis algorithms for digital histopathology images has…

图像与视频处理 · 电气工程与系统科学 2020-04-01 Alison K. Cheeseman , Hamid R. Tizhoosh , Edward R. Vrscay

Automatic histopathology image segmentation is crucial to disease analysis. Limited available labeled data hinders the generalizability of trained models under the fully supervised setting. Semi-supervised learning (SSL) based on generative…

计算机视觉与模式识别 · 计算机科学 2020-12-18 Hongxiao Wang , Hao Zheng , Jianxu Chen , Lin Yang , Yizhe Zhang , Danny Z. Chen

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

图像与视频处理 · 电气工程与系统科学 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Optical imaging of metabolism can provide key information about health and disease progression in cells and tissues, however, current methods have lacked gold-standard information about histological structure. Conversely, histology and…

Whole slide imaging provides a wide field-of-view (FOV) across cross-sections of biopsy or surgery samples, significantly facilitating pathological analysis and clinical diagnosis. Such high-quality images that enable detailed visualization…

光学 · 物理学 2024-07-31 Shi Zhao , Haowen Zhou , Siyu Lin , Ruizhi Cao , Changhuei Yang

Z-stack scanning is an emerging whole slide imaging technology that captures multiple focal planes alongside the z-axis of a glass slide. Because z-stacking can offer enhanced depth information compared to the single-layer whole slide…

图像与视频处理 · 电气工程与系统科学 2025-01-28 Hongyan Gu , Ellie Onstott , Wenzhong Yan , Tengyou Xu , Ruolin Wang , Zida Wu , Xiang 'Anthony' Chen , Mohammad Haeri

We propose a new method for cancer subtype classification from histopathological images, which can automatically detect tumor-specific features in a given whole slide image (WSI). The cancer subtype should be classified by referring to a…

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due…

计算机视觉与模式识别 · 计算机科学 2026-02-26 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Jiang Gui