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Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…

软凝聚态物质 · 物理学 2023-02-22 Qi Chen , Naval Singh , Kerstin Schirrmann , Qi Zhou , Igor Chernyavsky , Anne Juel

Modeling of the red blood cell (RBC) shape is an integral part of the experimental and computer simulation investigations of light scattering by these cells for fundamental studies as well as diagnostic applications in techniques like…

生物物理 · 物理学 2024-06-18 Gaurav D. Bhabhor , Chetna Patel , Nishant Chhillar , Arun Anand , Kirit N. Lad

Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic properties of biomedical devices, wherein the large scale blood circulation needs to be simulated by accounting for the mechanical response of red…

流体动力学 · 物理学 2024-12-24 F. Guglietta , M. Behr , L. Biferale , G. Falcucci , M. Sbragaglia

The fluid dynamics video presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several numerical…

流体动力学 · 物理学 2010-10-18 Daniel A. Reasor , Jonathan R. Clausen , Brian M. Yun , Cyrus K. Aidun

Red Blood Cells flowing in a microchannel undergo dispersion in the flow direction due to the non-uniform velocity profile while transverse migration due to cell-wall interactions tends to focus them along the center line. This results in a…

流体动力学 · 物理学 2024-03-19 Sylvain Losserand , Gwennou Coupier , Thomas Podgorski

Driven or active suspensions can display fascinating collective behavior, where coherent motions or structures arise on a scale much larger than that of the constituent particles. Here, we report experiments and numerical simulations…

We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic…

生物物理 · 物理学 2007-05-23 E. P. Furlani

Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer…

图像与视频处理 · 电气工程与系统科学 2019-12-17 Wei Qiu , Jiaming Guo , Xiang Li , Mengjia Xu , Mo Zhang , Ning Guo , Quanzheng Li

Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of…

流体动力学 · 物理学 2019-12-03 Asena Abay , Steffen M. Recktenwald , Thomas John , Lars Kaestner , Christian Wagner

The flow behavior of blood in microvessels is directly associated with tissue perfusion and oxygen delivery. Current efforts on modeling blood flow have primarily focused on the flow properties of blood with red blood cells (RBCs) having a…

软凝聚态物质 · 物理学 2024-06-03 Wei Chien , Gerhard Gompper , Dmitry A. Fedosov

Microfluidic technologies are commonly used for the manipulation of red blood cell (RBC) suspensions and analyses of flow-mediated biomechanics. To enhance the performance of microfluidic devices, understanding the dynamics of the…

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

计算机视觉与模式识别 · 计算机科学 2021-06-24 Sai Sukruth Bezugam

The red blood cell (RBC) membrane is composed of a lipid bilayer and a cytoskeleton interconnected by protein junction complexes, allowing for potential sliding between the lipid bilayer and the cytoskeleton. Despite this biological…

流体动力学 · 物理学 2024-01-23 V. Puthumana , P. G. Chen , M. Leonetti , R. Lasserre , M. Jaeger

Human immune system contains white blood cells (WBC) that are good indicator of many diseases like bacterial infections, AIDS, cancer, spleen, etc. White blood cells have been sub classified into four types: monocytes, lymphocytes,…

图像与视频处理 · 电气工程与系统科学 2024-10-15 Rabia Asghar , Arslan Shaukat , Usman Akram , Rimsha Tariq

We present experiments on RBCs that flow through microcapillaries under physiological conditions. We show that the RBC clusters form as a subtle imbrication between hydrodynamics interaction and adhesion forces because of plasma proteins.…

The red blood cells or erythrocytes are biconcave shaped cells and consist mostly in a membrane delimiting a cytosol with a high concentration in hemoglobin. This membrane is highly deformable and allows the cells to go through narrow…

生物物理 · 物理学 2012-06-27 Benjamin Mauroy

Partitioning of red blood cells (RBCs) at the level of bifurcations in the microcirculatory system affects many physiological functions yet it remains poorly understood. We address this problem by using T-shaped microfluidic bifurcations as…

Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions for fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a…

The dynamics of red blood cells (RBCs) in simple shear flow was studied using a theoretical approach based on three variables: a shape parameter, the inclination angle $\theta$, and phase angle $\phi$ of the membrane rotation. At high shear…

软凝聚态物质 · 物理学 2009-08-07 Hiroshi Noguchi

Intravital microscopy is an essential tool that reveals behaviours of live cells under conditions close to natural physiological states. So far, although various approaches for imaging cells in vivo have been proposed, most require the use…

生物物理 · 物理学 2016-07-04 Kyoohyun Kim , Kibaek Choe , Inwon Park , Pilhan Kim , YongKeun Park