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Embedding efficient command operation into biochemical system has always been a research focus in synthetic biology. One of the key problems is how to sequence the chemical reactions that act as units of computation. The answer is to design…

动力系统 · 数学 2022-09-08 Xiaopeng Shi , Chuanhou Gao

Regulation of multiple reaction modules is quite common in molecular computation and deep learning networks construction through chemical reactions, as is always a headache for that sequential execution of modules goes against the…

动力系统 · 数学 2022-11-08 Xiaopeng Shi , Chuanhou Gao , Denis Dochain

Embedding sequential computations in biochemical environments is challenging because the computations are carried out by chemical reactions, which are inherently disordered. In this paper we apply modular design to specific calculations…

分子网络 · 定量生物学 2024-01-05 Xiaopeng Shi , Chuanhou Gao , Denis Dochain

An intriguing interpretation of the time-evolution of dynamical systems is to view it as a computation that transforms an initial state to a final one. This paradigm has been explored in discrete systems such as cellular automata models,…

斑图形成与孤子 · 物理学 2014-05-13 Shakti N. Menon , Sitabhra Sinha

Oscillatory chemical reactions often serve as a timing clock of cellular processes in living cells. The temporal dynamics of protein concentration levels is thus of great interest in biology. Here we propose a theoretical framework to…

系统与控制 · 计算机科学 2015-03-20 Yutaka Hori , Shinji Hara

Living systems regulate many aspects of their behavior through periodic oscillations of molecular concentrations, which function as `biochemical clocks.' These clocks are intrinsically subject to thermal fluctuations, so that the duration…

生物物理 · 物理学 2020-08-10 Robert Marsland , Wenping Cui , Jordan M. Horowitz

Common models of circadian rhythms are constructed as compartmental reactions of well mixed biochemicals involving a negative-feedback loop containing several intermediate reaction steps in order to enable oscillations. Spatial transport of…

生物物理 · 物理学 2023-03-22 Pablo Rojas , Oreste Piro , Martin E. Garcia

We study chemical oscillators in the presence of phase separation. By imposing timescale separation between slow reactions and fast diffusion, we define a dynamics at phase equilibrium for the relevant degrees of freedom. We demonstrate…

软凝聚态物质 · 物理学 2025-07-23 Jonathan Bauermann , Giacomo Bartolucci , Artemy Kolchinsky

We study the dynamic electrical response of a silicon-molecular monolayer-metal junctions and we observe two contributions in the admittance spectroscopy data. These contributions are related to dipolar relaxation and molecular organization…

介观与纳米尺度物理 · 物理学 2010-07-27 Nicolas Clement , Stephane Pleutin , David Guerin , Dominique Vuillaume

The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be…

分子网络 · 定量生物学 2012-10-25 Ozgur Akman , Steven Watterson , Andrew Parton , Nigel Binns , Andrew Millar , Peter Ghazal

This paper presents a new method for evaluating the synchronization of quasi-periodic oscillations of two oscillators, termed "chimeric synchronization". The family of metrics is proposed to create a neural network information converter…

适应与自组织系统 · 物理学 2019-08-20 Andrei Velichko

A driven linear oscillator and a feedback mechanism are two necessary elements of any classical periodic clock. Here, we introduce a novel, fully quantum clock using a driven oscillator in the quantum regime and coherent quantum feedback.…

量子物理 · 物理学 2024-10-31 Stefan Zeppetzauer , Leonardo Assis Morais , Xin He , Gerard Milburn , Arkady Fedorov

A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has…

系统与控制 · 计算机科学 2014-02-26 Yongqiang Wang , Yutaka Hori , Shinji Hara , Francis J. Doyle

Numerical modelling of coherent spin relaxation in nanomagnets, formed by magnetic molecules of high spins, is accomplished. Such a coherent spin dynamics can be realized in the presence of a resonant electric circuit coupled to the magnet.…

介观与纳米尺度物理 · 物理学 2009-11-13 V. I. Yukalov , V. K. Henner , P. V. Kharebov

Organisms often use cyclic changes in the concentrations of chemicals species to precisely time biological functions. Underlying these biochemical clocks are chemical reactions and transport processes, which are inherently stochastic.…

统计力学 · 物理学 2020-02-06 Clara del Junco , Suriyanarayanan Vaikuntanathan

Coupled relaxation oscillators, realized via chemical or other means, can exhibit a multiplicity of steady states, characterized by spatial patterns resulting from lateral inhibition. We show that perturbation-initiated transformations…

斑图形成与孤子 · 物理学 2023-06-22 A. Parveena Shamim , Shakti N. Menon , Sitabhra Sinha

Cluster synchronization is of paramount importance for the normal functioning of numerous technological and natural systems. Deviations from normal cluster synchronization patterns are closely associated with various malfunctions, such as…

最优化与控制 · 数学 2023-08-15 Yuzhen Qin , Alberto Maria Nobili , Danielle S. Bassett , Fabio Pasqualetti

We study a system of dynamical units, each of which shows excitable or oscillatory behavior, depending on the choice of parameters. When we couple these units with repressive bonds, we can control the duration of collective oscillations for…

分子网络 · 定量生物学 2014-02-06 Darka Labavic , Hildegard Meyer-Ortmanns

Cluster synchronization is of great importance for the normal functioning of numerous technological and natural systems. Deviations from normal cluster synchronization patterns are closely associated with various malfunctions, such as…

系统与控制 · 电气工程与系统科学 2025-09-23 Yuzhen Qin , Alberto Maria Nobili , Danielle S. Bassett , Fabio Pasqualetti

Control-based continuation (CBC) is an experimental method that can reveal stable and unstable dynamics of physical systems. It extends the path-following principles of numerical continuation to experiments, and provides systematic…

动力系统 · 数学 2023-01-18 Mark Blyth , Krasimira Tsaneva-Atanasova , Lucia Marucci , Ludovic Renson
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