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In interventional health studies, causal mediation analysis can be employed to investigate mechanisms through which the intervention affects the targeted health outcome. Identifying direct and indirect (i.e. mediated) effects from empirical…

Mediation analysis extending beyond single mediators has gained significant attention in recent years. However, related methods often assume the absence of unmeasured mediator-outcome confounding. To address this, we develop a mediation…

统计方法学 · 统计学 2026-03-31 Kang Shuai , Lan Liu , Yangbo He , Wei Li

Mediation analysis is widely used for exploring treatment mechanisms; however, it faces challenges when nonignorable missing confounders are present. Efficient inference of mediation effects and the efficiency loss due to nonignorable…

统计方法学 · 统计学 2026-04-22 Jiawei Shan , Wei Li , Chunrong Ai

Recent advances in causal mediation analysis have formalized conditions for estimating direct and indirect effects in various contexts. These approaches have been extended to a number of models for survival outcomes including accelerated…

统计方法学 · 统计学 2017-01-11 Isabel R. Fulcher , Eric Tchetgen Tchetgen , Paige L. Williams

Some classical uncertainty quantification problems require the estimation of multiple expectations. Estimating all of them accurately is crucial and can have a major impact on the analysis to perform, and standard existing Monte Carlo…

统计方法学 · 统计学 2022-12-02 Julien Demange-Chryst , François Bachoc , Jérôme Morio

Mediation analysis in high-dimensional settings often involves identifying potential mediators among a large number of measured variables. For this purpose, a two-step familywise error rate procedure called ScreenMin has been recently…

统计方法学 · 统计学 2020-07-07 Vera Djordjilović , Jesse Hemerik , Magne Thoresen

Mediation analysis has been widely used to investigate how a treatment influences an outcome through intermediate variables, known as mediators. Analyzing a mediation mechanism typically requires assessing multiple model parameters that…

统计方法学 · 统计学 2025-10-01 Hanying Jiang , Kris Sankaran , Yinqiu He

The goal of this article is to select important variables that can distinguish one class of data from another. A marginal variable selection method ranks the marginal effects for classification of individual variables, and is a useful and…

统计方法学 · 统计学 2014-02-19 Xingye Qiao , Yufeng Liu , J. S. Marron

Analyses of causal mediation often involve exposure-induced confounders or, relatedly, multiple mediators. In such applications, researchers aim to estimate a variety of different quantities, including interventional direct and indirect…

统计方法学 · 统计学 2025-06-18 Jesse Zhou , Geoffrey T. Wodtke

We consider mediated effects of an exposure, X on an outcome, Y, via a mediator, M, under no unmeasured confounding assumptions in the setting where models for the conditional expectation of the mediator and outcome are partially linear. We…

统计方法学 · 统计学 2025-01-08 Oliver Hines , Stijn Vansteelandt , Karla Diaz-Ordaz

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator…

统计方法学 · 统计学 2026-05-19 Yuki Ohnishi , Fan Li

Mediation analyses allow researchers to quantify the effect of an exposure variable on an outcome variable through a mediator variable. If a binary mediator variable is misclassified, the resulting analysis can be severely biased.…

统计方法学 · 统计学 2024-07-19 Kimberly A. Hochstedler Webb , Martin T. Wells

Mediation analysis is a crucial tool for uncovering the mechanisms through which a treatment affects the outcome, providing deeper causal insights and guiding effective interventions. Despite advances in analyzing the mediation effect with…

统计方法学 · 统计学 2025-08-11 Shi Bo , AmirEmad Ghassami , Debarghya Mukherjee

To estimate direct and indirect effects of an exposure on an outcome from observed data strong assumptions about unconfoundedness are required. Since these assumptions cannot be tested using the observed data, a mediation analysis should…

统计理论 · 数学 2018-03-29 Anita Lindmark , Xavier de Luna , Marie Eriksson

While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have…

统计理论 · 数学 2012-10-18 Eric J. Tchetgen Tchetgen , Ilya Shpitser

This paper explores the effects of simulated moments on the performance of inference methods based on moment inequalities. Commonly used confidence sets for parameters are level sets of criterion functions whose boundary points may depend…

计量经济学 · 经济学 2018-04-12 Hiroaki Kaido , Jiaxuan Li , Marc Rysman

Recurrent events, including cardiovascular events, are commonly observed in biomedical studies. Researchers must understand the effects of various treatments on recurrent events and investigate the underlying mediation mechanisms by which…

统计方法学 · 统计学 2025-07-08 Yan-Lin Chen , Yan-Hong Chen , Pei-Fang Su , Huang-Tz Ou , An-Shun Tai

Inference in models where the parameter is defined by moment inequalities is of interest in many areas of economics. This paper develops a new method for improving the performance of generalized moment selection (GMS) testing procedures in…

计量经济学 · 经济学 2020-08-26 Rami V. Tabri , Christopher D. Walker

The Complete Mediation Test (CMT) serves as a specialized approach of mediation analysis to assess whether an independent variable A, influences an outcome variable Y exclusively through a mediator M, without any direct effect. An…

统计方法学 · 统计学 2025-07-22 Yichin Tsai , Wan-Tzu Chang , Jia Jyun Sie , Cathy SJ Fann , Iebin Lian

E-commerce companies have a number of online products, such as organic search, sponsored search, and recommendation modules, to fulfill customer needs. Although each of these products provides a unique opportunity for users to interact with…

应用统计 · 统计学 2020-06-23 Xuan Yin , Liangjie Hong