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This work presents a theoretical analysis of the probability of successfully retrieving data encoded with MDS codes (e.g., Reed-Solomon codes) in DNA storage systems. We study this probability under independent and identically distributed…

信息论 · 计算机科学 2026-05-08 Serge Kas Hanna

We propose a new distance metric for DNA sequences, which can be defined on any evolutionary Markov model with infinitesimal generator matrix Q. That is the new metric can be defined under existing models such as Jukes-Cantor model,…

种群与进化 · 定量生物学 2009-02-12 Viswanath. C. Narayanan

MDS codes have garnered significant attention due to their wide applications in practice. To date, most known MDS codes are equivalent to Reed-Solomon codes. The construction of non-Reed-Solomon (non-RS) type MDS codes has emerged as an…

信息论 · 计算机科学 2024-11-25 Lingfei Jin , Liming Ma , Chaoping Xing , Haiyan Zhou

DNA has emerged as a promising alternative for long-term data storage due to its high capacity, durability, and low-energy potential. However, storing data in DNA presents several challenges. First, it requires complex and costly…

其他定量生物学 · 定量生物学 2025-11-20 Sara Al Sayyed , Aline Roumy , Thomas Maugey

The human genome contains repetitive DNA at different level of sequence length, number and dispersion. Highly repetitive DNA is particularly rich in homo-- and di--nucleotide repeats, while middle repetitive DNA is rich of families of…

基因组学 · 定量生物学 2009-11-11 Francesco Piazza , Pietro Lio

In a DNA sequence, we have the celebrated Watson-Crick complement $\overline{T}=A$, $\overline{A}=T$, $\overline{C}=G$, and $\overline{G}=C$. Given an integer $m\ge 2$, a secondary structure in a DNA sequence refers to the existence of two…

信息论 · 计算机科学 2023-04-25 Hui Chu , Chen Wang , Yiwei Zhang

A convolutional code $\C$ over $\ZZ[D]$ is a $\ZZ[D]$-submodule of $\ZZN[D]$ where $\ZZ[D]$ stands for the ring of polynomials with coefficients in $\ZZ$. In this paper, we study the list decoding problem of these codes when the…

信息论 · 计算机科学 2020-09-09 Julia Lieb , Diego Napp , Raquel Pinto

We propose a new compression scheme for genomic data given as sequence fragments called reads. The scheme uses a reference genome at the decoder side only, freeing the encoder from the burdens of storing references and performing…

信息论 · 计算机科学 2023-02-10 Yotam Gershon , Yuval Cassuto

DNA data storage offers a high-density, long-term alternative to traditional storage systems, addressing the exponential growth of digital data. Composite DNA extends this paradigm by leveraging mixtures of nucleotides to increase storage…

信息论 · 计算机科学 2026-02-13 Busra Tegin , Tolga M Duman

The classification of DNA sequences is a key research area in bioinformatics as it enables researchers to conduct genomic analysis and detect possible diseases. In this paper, three state-of-the-art algorithms, namely Convolutional Neural…

其他定量生物学 · 定量生物学 2020-11-03 Xiangxie Zhang , Ben Beinke , Berlian Al Kindhi , Marco Wiering

DNA has immense potential as an emerging data storage medium. The principle of DNA storage is the conversion and flow of digital information between binary code stream, quaternary base, and actual DNA fragments. This process will inevitably…

信息检索 · 计算机科学 2022-10-21 Yun Qin , Fei Zhu , Bo Xi

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

信息论 · 计算机科学 2022-02-15 Nir Weinberger , Neri Merhav

As DNA data storage moves closer to practical deployment, minimizing sequencing coverage depth is essential to reduce both operational costs and retrieval latency. This paper addresses the recently studied Random Access Problem, which…

信息论 · 计算机科学 2026-01-13 Chen Wang , Eitan Yaakobi

Effective and reliable data retrieval is critical for the feasibility of DNA storage, and the development of random access efficiency plays a key role in its practicality and reliability. In this paper, we study the Random Access Problem,…

信息论 · 计算机科学 2025-10-10 Anina Gruica , Maria Montanucci , Ferdinando Zullo

We have developed a generalized semi-analytic approach for efficiently computing cyclization and looping $J$ factors of DNA under arbitrary binding constraints. Many biological systems involving DNA-protein interactions impose precise…

生物大分子 · 定量生物学 2015-05-14 David P. Wilson , Alexei V. Tkachenko , Jens-Christian Meiners

Recently, DNA storage has surfaced as a promising alternative for data storage, presenting notable benefits in terms of storage capacity, cost-effectiveness in maintenance, and the capability for parallel replication. Mathematically, the…

信息论 · 计算机科学 2024-01-31 Yi Lu , Yun Ma , Chenghao Li , Xin Zhang , Guangxiang Si

DNA-based storage is an emerging storage technology that provides high information density and long duration. Due to the physical constraints in the reading and writing processes, error correction in DNA storage poses several interesting…

信息论 · 计算机科学 2023-10-04 Jin Sima , Netanel Raviv , Moshe Schwartz , Jehoshua Bruck

This paper extends the foundational work of Dollma \emph{et al}. on codes for ordered composite DNA sequences. We consider the general setting with an alphabet of size $q$ and a resolution parameter $k$, moving beyond the binary ($q=2$)…

信息论 · 计算机科学 2026-02-19 Zuo Ye , Yuling Li , Zhaojun Lan , Gennian Ge

Let $R=\mathbb{Z}_4+u\mathbb{Z}_4,$ where $\mathbb{Z}_4$ denotes the ring of integers modulo $4$ and $u^2=0$. In the present paper, we introduce a new Gray map from $R^n$ to $\mathbb{Z}_{4}^{2n}.$ We study $(1+2u)$-constacyclic codes over…

环与代数 · 数学 2015-04-15 Mohammad Ashraf , Ghulam Mohammad

MDS codes have diverse practical applications in communication systems, data storage, and quantum codes due to their algebraic properties and optimal error-correcting capability. In this paper, we focus on a class of linear codes and…

信息论 · 计算机科学 2024-01-09 Yansheng Wu , Ziling Heng , Chengju Li , Cunsheng Ding