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Cancer is a complex disease characterized by uncontrolled cell growth and proliferation. T cell receptors (TCRs) are essential proteins for the adaptive immune system, and their specific recognition of antigens plays a crucial role in the…

机器学习 · 计算机科学 2023-09-07 Zahra Tayebi , Sarwan Ali , Prakash Chourasia , Taslim Murad , Murray Patterson

We propose a new methodology for selecting and ranking covariates associated with a variable of interest in a context of high-dimensional data under dependence but few observations. The methodology successively intertwines the clustering of…

The reservoir computing paradigm is employed to classify heartbeat anomalies online based on electrocardiogram signals. Inspired by the principles of information processing in the brain, reservoir computing provides a framework to design,…

机器学习 · 计算机科学 2019-07-24 Fatemeh Hadaeghi

Language models can be sampled multiple times to access the distribution underlying their responses, but existing methods cannot efficiently synthesize rich epistemic signals across different long-form responses. We introduce Consensus…

计算与语言 · 计算机科学 2025-10-07 Sayan Ghosh , Shahzaib Saqib Warraich , Dhruv Tarsadiya , Gregory Yauney , Swabha Swayamdipta

Determining the adsorption isotherms is an issue of significant importance in preparative chromatography. A modern technique for estimating adsorption isotherms is to solve an inverse problem so that the simulated batch separation coincides…

应用统计 · 统计学 2022-11-24 Jiaji Su , Zhigang Yao , Cheng Li , Ye Zhang

This paper discusses distributed approaches for the solution of random convex programs (RCP). RCPs are convex optimization problems with a (usually large) number N of randomly extracted constraints; they arise in several applicative areas,…

最优化与控制 · 数学 2012-07-27 Luca Carlone , Vaibhav Srivastava , Francesco Bullo , Giuseppe Calafiore

This paper presents a novel sampling scheme for masked non-autoregressive generative modeling. We identify the limitations of TimeVQVAE, MaskGIT, and Token-Critic in their sampling processes, and propose Enhanced Sampling Scheme (ESS) to…

机器学习 · 计算机科学 2023-09-18 Daesoo Lee , Erlend Aune , Sara Malacarne

Waveform signal analysis is a complex and important task in medical care. For example, mechanical ventilators are critical life-support machines, but they can cause serious injury to patients if they are out of synchronization with the…

计算工程、金融与科学 · 计算机科学 2025-01-24 Wenjie Xu , Scott Dick

We consider offline detection of a single changepoint in binary and count time-series. We compare exact tests based on the cumulative sum (CUSUM) and the likelihood ratio (LR) statistics, and a new proposal that combines exact two-sample…

统计方法学 · 统计学 2020-08-21 Shyamal K. De , Soumendu Sundar Mukherjee

In this paper, we consider the patient similarity matching problem over a cancer cohort of more than 220,000 patients. Our approach first leverages on Word2Vec framework to embed ICD codes into vector-valued representation. We then propose…

机器学习 · 计算机科学 2016-12-07 Dang Nguyen , Wei Luo , Dinh Phung , Svetha Venkatesh

Despite remarkable performance in producing realistic samples, Generative Adversarial Networks (GANs) often produce low-quality samples near low-density regions of the data manifold, e.g., samples of minor groups. Many techniques have been…

机器学习 · 计算机科学 2021-10-28 Jinhee Lee , Haeri Kim , Youngkyu Hong , Hye Won Chung

The need to estimate a particular quantile of a distribution is an important problem which frequently arises in many computer vision and signal processing applications. For example, our work was motivated by the requirements of many…

计算机视觉与模式识别 · 计算机科学 2015-04-22 Ognjen Arandjelovic , Duc-Son Pham , Svetha Venkatesh

Overconfidence in deep learning models poses a significant risk in high-stakes medical imaging tasks, particularly in multi-label classification of chest X-rays, where multiple co-occurring pathologies must be detected simultaneously. This…

图像与视频处理 · 电气工程与系统科学 2025-09-15 Yehudit Aperstein , Amit Tzahar , Alon Gottlib , Tal Verber , Ravit Shagan Damti , Alexander Apartsin

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering…

定量方法 · 定量生物学 2023-01-11 Nana Wei , Yating Nie , Lin Liu , Xiaoqi Zheng , Hua-Jun Wu4

T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted…

机器学习 · 计算机科学 2024-08-05 Yicheng Lin , Dandan Zhang , Yun Liu

Motivated by the inquiries of weak signals in underpowered genome-wide association studies (GWASs), we consider the problem of retaining true signals that are not strong enough to be individually separable from a large amount of noise. We…

统计方法学 · 统计学 2024-02-05 X. Jessie Jeng , Yifei Hu , Quan Sun , Yun Li

Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive)and type II (false negative) errors. In this work, we develop a statistical model to study how medical…

应用统计 · 统计学 2025-10-21 Lucas Böttcher , Maria R. D'Orsogna , Tom Chou

An important paradigm in smart health is developing diagnosis tools and monitoring a patient's heart activity through processing Electrocardiogram (ECG) signals is a key example, sue to high mortality rate of heart-related disease. However,…

信号处理 · 电气工程与系统科学 2018-11-02 Jiaming Chen , Ali Valehi , Abolfazl Razi

This paper studies graph-based active learning, where the goal is to reconstruct a binary signal defined on the nodes of a weighted graph, by sampling it on a small subset of the nodes. A new sampling algorithm is proposed, which…

机器学习 · 计算机科学 2016-05-19 Eyal En Gad , Akshay Gadde , A. Salman Avestimehr , Antonio Ortega

In a typical Event-Based Surveillance setting, a stream of web documents is continuously monitored for disease reporting. A structured representation of the disease reporting events is extracted from the raw text, and the events are then…

计算机与社会 · 计算机科学 2011-01-05 Avaré Stewar , Ricardo Lage , Ernesto Diaz-Aviles , Peter Dolog