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We investigate the generalized Poland-Scheraga model, which is used in the bio-physical literature to model the DNA denaturation transition, in the case where the two strands are allowed to be non-complementary (and to have different…

概率论 · 数学 2018-07-31 Quentin Berger , Giambattista Giacomin , Maha Khatib

The Poland-Scheraga model is a celebrated model for the denaturation transition of DNA, which has been widely used in the bio-physical literature to study, and investigated by mathematicians. In the original model, only opposite bases of…

概率论 · 数学 2020-11-05 Alexandre Legrand

We numerically study the binary disordered Poland-Scheraga model of DNA denaturation, in the regime where the pure model displays a first order transition (loop exponent $c=2.15>2$). We use a Fixman-Freire scheme for the entropy of loops…

无序系统与神经网络 · 物理学 2007-05-23 Thomas Garel , Cecile Monthus

The Poland-Scheraga model for DNA denaturation, besides playing a central role in applications, has been widely studied in the physical and mathematical literature over the past decades. More recently a natural generalization has been…

概率论 · 数学 2017-03-31 Quentin Berger , Giambattista Giacomin , Maha Khatib

The Poland-Scheraga model describes the denaturation transition of two complementary - in particular, equally long - strands of DNA, and it has enjoyed a remarkable success both for quantitative modeling purposes and at a more theoretical…

概率论 · 数学 2015-10-28 Giambattista Giacomin , Maha Khatib

Poland-Scheraga models were introduced to describe the DNA denaturation transition. We give a rigorous and refined discussion of a family of these models. We derive possible scaling functions in the neighborhood of the phase transition…

统计力学 · 物理学 2008-08-28 C. Richard , A. J. Guttmann

We compare results of previous simulations of a simple model of DNA denaturation to the predictions of the Poland-Scheraga model. Concentrating on the critical region of the latter model we calculate both thermodynamic quantities and the…

统计力学 · 物理学 2007-05-23 Lothar Schäfer

We perform an extensive numerical study of the disordered Poland-Scheraga (PS) model for DNA denaturation in which self-avoidance is completely taken into account. In complement to our previous work, we focus here on the finite size scaling…

软凝聚态物质 · 物理学 2016-05-05 Barbara Coluzzi , Edouard Yeramian

We discuss possible mechanisms that may impact the order of the transition between denaturated and bound DNA states and lead to changes in the scaling laws that govern conformational properties of DNA strands. To this end, we re-consider…

软凝聚态物质 · 物理学 2021-04-07 Yulian Honchar , Christian von Ferber , Yurij Holovatch

The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect…

统计力学 · 物理学 2009-01-28 Marco Baiesi , Roberto Livi

We study numerically the effect of sequence heterogeneity on the thermodynamic properties of a Poland-Scheraga model for DNA denaturation taking into account self-avoidance, i.e. with exponent c_p=2.15 for the loop length probability…

无序系统与神经网络 · 物理学 2016-05-06 Barbara Coluzzi , Edouard Yeramian

We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force. We demonstrate the existence of a force-induced DNA denaturation transition and obtain the temperature-force phase…

软凝聚态物质 · 物理学 2009-11-13 Andreas Hanke , Martha G. Ochoa , Ralf Metzler

Using a field theory equivalent to a lattice version of the Poland-Scheraga (PS) model, the phase diagram for a long DNA molecule is derived in closed form. A one-loop renormalization group calculation for the generalized PS model with…

软凝聚态物质 · 物理学 2026-04-01 Richard Dengler

The Poland-Scheraga (PS) model for the helix-coil transition of DNA considers the statistical mechanics of the binding (or hybridization) of two complementary strands of DNA of equal length, with the restriction that only bases with the…

生物大分子 · 定量生物学 2007-05-23 Thomas Garel , Henri Orland

We study numerically a disordered version of the model for DNA denaturation transition (DSAW-DNA) consisting of two interacting SAWs in 3d, which undergoes a first order transition in the homogeneous case. The two possible values eAT and…

软凝聚态物质 · 物理学 2009-11-11 Barbara Coluzzi

In the framework of the Poland Scheraga model of DNA denaturation, we derive a recursion relation for the partition function of double stranded DNA, allowing for mismatches between the two strands. This relation is studied numerically using…

软凝聚态物质 · 物理学 2007-05-23 T. Garel , H. Orland

We present a precise equivalence of the Lifson-Poland-Scheraga model with wetting models. Making use of a representation of the former model in terms of random matrices, we obtain, in the limit of weak disorder, a mean--field approximation,…

统计力学 · 物理学 2015-06-05 Hervé Kunz , Roberto Livi

The distance distribution between complementary base pairs of the two strands of a DNA molecule is studied near the melting transition. Scaling arguments are presented for a generalized Poland-Scheraga type model which includes…

统计力学 · 物理学 2009-11-07 M. Baiesi , E. Carlon , Y. Kafri , D. Mukamel , E. Orlandini , A. L. Stella

The denaturation transition which takes place in circular DNA is analyzed by extending the Poland-Scheraga model to include the winding degrees of freedom. We consider the case of a homopolymer whereby the winding number of the double…

统计力学 · 物理学 2011-11-22 Amir Bar , Alkan Kabakçıoğlu , David Mukamel

We give an overview of the state of the art of the analysis of disordered models of pinning on a defect line. This class of models includes a number of well known and much studied systems (like polymer pinning on a defect line, wetting of…

数学物理 · 物理学 2008-07-29 Giambattista Giacomin
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