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We propose a deep generative approach to nonparametric estimation of conditional survival and hazard functions with right-censored data. The key idea of the proposed method is to first learn a conditional generator for the joint conditional…

统计理论 · 数学 2022-05-20 Xingyu Zhou , Wen Su , Changyu Liu , Yuling Jiao , Xingqiu Zhao , Jian Huang

Structural Nested Mean Models (SNMMs) are useful for causal inference of treatment effects in longitudinal observational studies. Most existing works assume that the data are collected at pre-fixed time points for all subjects, which,…

统计方法学 · 统计学 2020-01-13 Shu Yang

With reference to a binary outcome and a binary mediator, we derive identification bounds for natural effects under a reduced set of assumptions. Specifically, no assumptions about confounding are made that involve the outcome; we only…

统计方法学 · 统计学 2026-04-03 Marco Doretti , Elena Stanghellini

When analyzing time-to-event data, it often happens that some subjects do not experience the event of interest. Survival models that take this feature into account (called `cure models') have been developed in the presence of covariates.…

统计理论 · 数学 2019-09-19 Mikael Escobar-Bach , Ingrid Van Keilegom

We propose a new likelihood-based approach for estimation, inference and variable selection for parametric cure regression models in time-to-event analysis under random right-censoring. In this context, it often happens that some subjects…

统计方法学 · 统计学 2020-07-17 Kevin Burke , Valentin Patilea

Recent years have seen the development of many novel scoring tools for disease prognosis and prediction. To become accepted for use in clinical applications, these tools have to be validated on external data. In practice, validation is…

统计方法学 · 统计学 2022-12-06 Matthias Schmid , Tim Friede , Nadja Klein , Leonie Weinhold

The goals in clinical and cohort studies often include evaluation of the association of a time-dependent binary treatment or exposure with a survival outcome. Recently, several impactful studies targeted the association between…

应用统计 · 统计学 2019-01-24 Daniel Nevo , Tsuyoshi Hamada , Shuji Ogino , Molin Wang

We provide new results for nonparametric identification, estimation, and inference of causal effects using `proxy controls': observables that are noisy but informative proxies for unobserved confounding factors. Our analysis applies to…

计量经济学 · 经济学 2023-11-22 Ben Deaner

We consider Bayesian nonparametric inference in the right-censoring survival model, where modeling is made at the level of the hazard rate. We derive posterior limiting distributions for linear functionals of the hazard, and then for `many'…

统计理论 · 数学 2021-06-01 Ismaël Castillo , Stéphanie van der Pas

The purpose of this work is to improve the efficiency in estimating the average causal effect (ACE) on the survival scale where right-censoring exists and high-dimensional covariate information is available. We propose new estimators using…

统计方法学 · 统计学 2021-06-29 Ran Dai , Cheng Zheng , Mei-Jie Zhang

Typically, case-control studies to estimate odds-ratios associating risk factors with disease incidence from logistic regression only include cases with newly diagnosed disease. Recently proposed methods allow incorporating information on…

统计方法学 · 统计学 2020-10-19 Soutrik Mandal , Jing Qin , Ruth M. Pfeiffer

Analysis of random censored life-time data along with some related stochastic covariables is of great importance in many applied sciences like medical research, population studies and planning etc. The parametric estimation technique…

统计理论 · 数学 2019-05-09 Abhik Ghosh , Ayanendranath Basu

Survival analysis can sometimes involve individuals who will not experience the event of interest, forming what is known as the cured group. Identifying such individuals is not always possible beforehand, as they provide only right-censored…

统计方法学 · 统计学 2024-01-03 Jinqing Li , Jun Ma

Outcome-dependent sampling designs are common in many different scientific fields including epidemiology, ecology, and economics. As with all observational studies, such designs often suffer from unmeasured confounding, which generally…

统计方法学 · 统计学 2020-10-13 Erin E. Gabriel , Michael C. Sachs , Arvid Sjölander

Truncation is a statistical phenomenon that occurs in many time to event studies. For example, autopsy-confirmed studies of neurodegenerative diseases are subject to an inherent left and right truncation, also known as double truncation.…

统计方法学 · 统计学 2018-03-28 Lior Rennert , Sharon X. Xie

In this paper we address the challenges posed by non-proportional hazards and informative censoring, offering a path toward more meaningful causal inference conclusions. We start from the marginal structural Cox model, which has been widely…

统计方法学 · 统计学 2023-11-15 Jiyu Luo , Denise Rava , Jelena Bradic , Ronghui Xu

We consider generalized linear regression analysis with left-censored covariate due to the lower limit of detection. Complete case analysis by eliminating observations with values below limit of detection yields valid estimates for…

统计方法学 · 统计学 2014-12-09 Shengchun Kong , Bin Nan

Conditioning on some set of confounders that causally affect both treatment and outcome variables can be sufficient for eliminating bias introduced by all such confounders when estimating causal effect of the treatment on the outcome from…

统计方法学 · 统计学 2018-04-24 Priyantha Wijayatunga

When data contains measurement errors, it is necessary to make assumptions relating the observed, erroneous data to the unobserved true phenomena of interest. These assumptions should be justifiable on substantive grounds, but are often…

机器学习 · 统计学 2020-12-24 Noam Finkelstein , Roy Adams , Suchi Saria , Ilya Shpitser

Instrumental variable (IV) methods allow us the opportunity to address unmeasured confounding in causal inference. However, most IV methods are only applicable to discrete or continuous outcomes with very few IV methods for censored…

统计方法学 · 统计学 2020-09-30 Youjin Lee , Edward H. Kennedy , Nandita Mitra