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The appearance of a new dangerous and contagious disease requires the development of a drug therapy faster than what is foreseen by usual mechanisms. Many drug therapy developments consist in investigating through different clinical trials…

定量方法 · 定量生物学 2020-03-31 Ezequiel Alvarez , Federico Lamagna , Manuel Szewc

We study optimal covariate balance for causal inferences from observational data when rich covariates and complex relationships necessitate flexible modeling with neural networks. Standard approaches such as propensity weighting and…

机器学习 · 统计学 2018-02-16 Nathan Kallus

Machine learning models play a vital role in making predictions and deriving insights from data and are being increasingly used for causal inference. To preserve user privacy, it is important to enable the model to forget some of its…

机器学习 · 计算机科学 2023-08-29 Vikas Ramachandra , Mohit Sethi

Neural collaborative filtering is the state of art field in the recommender systems area; it provides some models that obtain accurate predictions and recommendations. These models are regression-based, and they just return rating…

信息检索 · 计算机科学 2024-10-28 Jesús Bobadilla , Abraham Gutiérrez , Santiago Alonso , Ángel González-Prieto

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

统计方法学 · 统计学 2023-01-23 Lars Lau Raket

Network regression models, where the outcome comprises the valued edge in a network and the predictors are actor or dyad-level covariates, are used extensively in the social and biological sciences. Valid inference relies on accurately…

统计方法学 · 统计学 2021-06-09 Mengjie Pan , Tyler H. McCormick , Bailey K. Fosdick

Network neuroscience is the emerging discipline concerned with investigating the complex patterns of interconnections found in neural systems, and to identify principles with which to understand them. Within this discipline, one…

神经元与认知 · 定量生物学 2017-08-29 Richard F. Betzel , Danielle S. Bassett

A further understanding of cause and effect within observational data is critical across many domains, such as economics, health care, public policy, web mining, online advertising, and marketing campaigns. Although significant advances…

机器学习 · 计算机科学 2023-04-11 Zhixuan Chu , Sheng Li

We propose a novel method for predicting time-to-event in the presence of cure fractions based on flexible survivals models integrated into a deep neural network framework. Our approach allows for non-linear relationships and…

机器学习 · 统计学 2024-11-11 Victor Medina-Olivares , Stefan Lessmann , Nadja Klein

When making treatment selection decisions, it is essential to include a causal effect estimation analysis to compare potential outcomes under different treatments or controls, assisting in optimal selection. However, merely estimating…

机器学习 · 统计学 2024-10-08 Sherly Alfonso-Sánchez , Kristina P. Sendova , Cristián Bravo

In estimating the effects of a treatment/policy with a network, an unit is subject to two types of treatment: one is the direct treatment on the unit itself, and the other is the indirect treatment (i.e., network/spillover influence)…

统计方法学 · 统计学 2025-06-16 Myoung-jae Lee

As predictive models -- e.g., from machine learning -- give likely outcomes, they may be used to reason on the effect of an intervention, a causal-inference task. The increasing complexity of health data has opened the door to a plethora of…

机器学习 · 统计学 2023-05-17 Matthieu Doutreligne , Gaël Varoquaux

To pricing health insurance plan, statisticians use mathematical models to predict customers' future health condition. General Addictive Model (GAM) is a wide accepted method for this problem. However, it have several limitations. To solve…

应用统计 · 统计学 2013-07-25 Guanxi Zhuang

Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the…

分子网络 · 定量生物学 2008-07-31 Zoltan Spiro , Istvan A. Kovacs , Peter Csermely

Estimating causal effects for survival outcomes in the high-dimensional setting is an extremely important topic for many biomedical applications as well as areas of social sciences. We propose a new orthogonal score method for treatment…

统计方法学 · 统计学 2024-12-04 Jue Hou , Jelena Bradic , Ronghui Xu

This work investigates the framework and performance issues of the composite neural network, which is composed of a collection of pre-trained and non-instantiated neural network models connected as a rooted directed acyclic graph for…

机器学习 · 计算机科学 2021-07-20 Ming-Chuan Yang , Meng Chang Chen

Uplift is a particular case of conditional treatment effect modeling. Such models deal with cause-and-effect inference for a specific factor, such as a marketing intervention or a medical treatment. In practice, these models are built on…

机器学习 · 统计学 2021-05-12 Mouloud Belbahri , Olivier Gandouet , Alejandro Murua , Vahid Partovi Nia

With the rise of online eTextbooks and Massive Open Online Courses (MOOCs), a huge amount of data has been collected related to students' learning. With the careful analysis of this data, educators can gain useful insights into the…

计算机与社会 · 计算机科学 2022-03-09 Ahmed Abd Elrahman , Taysir Hassan A Soliman , Ahmed I. Taloba , Mohammed F. Farghally

We study a continuous treatment effect model in the presence of treatment spillovers through social networks. We assume that one's outcome is affected not only by his/her own treatment but also by a (weighted) average of his/her neighbors'…

计量经济学 · 经济学 2023-01-12 Tadao Hoshino

In this chapter, we review the class of causal effects based on incremental propensity scores interventions proposed by Kennedy [2019]. The aim of incremental propensity score interventions is to estimate the effect of increasing or…

统计方法学 · 统计学 2021-10-22 Matteo Bonvini , Alec McClean , Zach Branson , Edward H. Kennedy