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Causal mediation analyses investigate the mechanisms through which causes exert their effects, and are therefore central to scientific progress. The literature on the non-parametric definition and identification of mediational effects in…

机器学习 · 统计学 2025-06-13 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Iván Díaz

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the…

统计方法学 · 统计学 2020-07-14 Margarita Moreno-Betancur , Paul Moran , Denise Becker , George C Patton , John B Carlin

Inferring causal relationships from observational data is often challenging due to endogeneity. This paper provides new identification results for causal effects of discrete, ordered and continuous treatments using multiple binary…

计量经济学 · 经济学 2024-10-21 Nadja van 't Hoff

We consider identification and inference about a counterfactual outcome mean when there is unmeasured confounding using tools from proximal causal inference (Miao et al. [2018], Tchetgen Tchetgen et al. [2020]). Proximal causal inference…

统计方法学 · 统计学 2023-10-03 Jeffrey Zhang , Wei Li , Wang Miao , Eric Tchetgen Tchetgen

Retrospective causal questions ask what would have happened to an observed individual had they received a different treatment. We study the problem of estimating $\mu(x,y)=\mathbb{E}[Y(1)\mid X=x,Y(0)=y]$, the expected counterfactual…

统计方法学 · 统计学 2026-03-31 Juraj Bodik

Mediation analyses are a statistical tool for testing the hypothesis about how the relationship between two variables may be direct or indirect via a third variable. Assessing statistical significance has been an area of active research;…

统计方法学 · 统计学 2021-06-07 Jason Steffener

In animal behavior studies, a common goal is to investigate the causal pathways between an exposure and outcome, and a mediator that lies in between. Causal mediation analysis provides a principled approach for such studies. Although many…

Causal mediation analysis is an important statistical tool to quantify effects transmitted by intermediate variables from a cause to an outcome. There is a gap in mediation analysis methods to handle mixture mediator data that are…

统计方法学 · 统计学 2025-07-22 Meilin Jiang , Seonjoo Lee , A. James O'Malley , Pengfei Li , Zhigang Li

Measurement error in observational datasets can lead to systematic bias in inferences based on these datasets. As studies based on observational data are increasingly used to inform decisions with real-world impact, it is critical that we…

机器学习 · 统计学 2019-01-29 Roy Adams , Yuelong Ji , Xiaobin Wang , Suchi Saria

We propose semi- and non-parametric methods to estimate conditional interventional effects in the setting of two discrete mediators whose causal ordering is unknown. Average interventional indirect effects have been shown to decompose an…

统计方法学 · 统计学 2023-04-19 Max Rubinstein , Zach Branson , Edward H. Kennedy

Most of the literature on direct and indirect effects assumes that there are no post-treatment common causes of the mediator and the outcome. In contrast to natural direct and indirect effects, organic direct and indirect effects, which…

统计方法学 · 统计学 2020-07-10 Judith J Lok

This paper develops an empirical balancing approach for the estimation of treatment effects under two-sided noncompliance using a binary conditionally independent instrumental variable. The method weighs both treatment and outcome…

计量经济学 · 经济学 2020-07-10 Phillip Heiler

Doubly robust estimators of causal effects are a popular means of estimating causal effects. Such estimators combine an estimate of the conditional mean of the outcome given treatment and confounders (the so-called outcome regression) with…

统计方法学 · 统计学 2019-01-17 David Benkeser , Weixin Cai , Mark J van der Laan

In causal mediation analysis, identification of existing causal direct or indirect effects requires untestable assumptions in which potential outcomes and potential mediators are independent. This paper defines a new causal direct and…

统计方法学 · 统计学 2020-09-29 Takahiro Hoshino

Conditioning on some set of confounders that causally affect both treatment and outcome variables can be sufficient for eliminating bias introduced by all such confounders when estimating causal effect of the treatment on the outcome from…

统计方法学 · 统计学 2018-04-24 Priyantha Wijayatunga

Proximal causal inference was recently proposed as a framework to identify causal effects from observational data in the presence of hidden confounders for which proxies are available. In this paper, we extend the proximal causal inference…

统计理论 · 数学 2023-01-27 AmirEmad Ghassami , Alan Yang , Ilya Shpitser , Eric Tchetgen Tchetgen

Mediation analysis learns the causal effect transmitted via mediator variables between treatments and outcomes and receives increasing attention in various scientific domains to elucidate causal relations. Most existing works focus on…

机器学习 · 统计学 2023-09-06 Lin Ge , Jitao Wang , Chengchun Shi , Zhenke Wu , Rui Song

Unobserved confounding is one of the main challenges when estimating causal effects. We propose a causal reduction method that, given a causal model, replaces an arbitrary number of possibly high-dimensional latent confounders with a single…

机器学习 · 统计学 2023-02-24 Maximilian Ilse , Patrick Forré , Max Welling , Joris M. Mooij

We introduce a flexible parametric mixed effects model for correlated binary data, with parameters that can be directly interpreted as marginal odds ratios. This leads to a robust estimation equation with an optimal weighting matrix being…

统计方法学 · 统计学 2014-04-01 Rui Zhang , Kwun Chuen Gary Chan

Misclassified binary outcome or mediator variables can cause unpredictable bias in resulting parameter estimates. As more datasets that were not originally collected for research purposes are being used for studies in the social and health…

统计计算 · 统计学 2025-01-15 Kimberly A. Hochstedler Webb , Martin T. Wells