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When assessing the causal effect of a binary exposure using observational data, confounder imbalance across exposure arms must be addressed. Matching methods, including propensity score-based matching, can be used to deconfound the causal…

统计方法学 · 统计学 2024-10-01 Ernesto Ulloa-Pérez , Marco Carone , Alex Luedtke

In the statistical literature, a number of methods have been proposed to ensure valid inference about marginal effects of variables on a longitudinal outcome in settings with irregular monitoring times. However, the potential biases due to…

统计方法学 · 统计学 2021-12-23 Janie Coulombe , Erica E M Moodie , Robert W Platt

The assumption that no subject's exposure affects another subject's outcome, known as the no-interference assumption, has long held a foundational position in the study of causal inference. However, this assumption may be violated in many…

统计方法学 · 统计学 2018-11-27 Caleb H. Miles , Maya Petersen , Mark J. van der Laan

For settings with a binary treatment and a binary outcome, instrumental variables can be used to construct bounds on a causal treatment effect. With continuous outcomes, meaningful bounds are more difficult to obtain because the domain of…

统计方法学 · 统计学 2013-03-26 Tao Liu , Joseph W. Hogan

Causal inference is widely used in various fields, such as biology, psychology and economics, etc. In observational studies, we need to balance the covariates before estimating causal effect. This study extends the one-dimensional entropy…

统计方法学 · 统计学 2022-05-19 Juan Chen , Yingchun Zhou

Perinatal epidemiology often aims to evaluate exposures on infant outcomes. When the exposure affects the composition of people who give birth to live infants (e.g., by affecting fertility, behavior, or birth outcomes), this "live birth…

统计方法学 · 统计学 2024-01-23 Shalika Gupta , Laura B. Balzer , Moses R. Kamya , Diane V. Havlir , Maya L. Petersen

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish…

统计方法学 · 统计学 2024-03-26 Jingyue Huang , Changbao Wu , Leilei Zeng

Causal inference is best understood using potential outcomes. This use is particularly important in more complex settings, that is, observational studies or randomized experiments with complications such as noncompliance. The topic of this…

统计理论 · 数学 2007-06-13 Donald B. Rubin

Causal mediation analysis decomposes the total effect of a treatment on an outcome into the indirect effect, operating through the mediator, and the direct effect, operating through other pathways. One can estimate only the pure indirect…

应用统计 · 统计学 2025-07-16 Vindyani Herath , Ronald J. Bosch , Judith J. Lok

We consider time to treatment initiation. This can commonly occur in preventive medicine, such as disease screening and vaccination; it can also occur with non-fatal health conditions such as HIV infection without the onset of AIDS. While…

统计方法学 · 统计学 2026-05-29 Zhichen Zhao , Andrew Ying , Ronghui Xu

The causal effect of an intervention (treatment/exposure) on an outcome can be estimated by: i) specifying knowledge about the data-generating process; ii) assessing under what assumptions a target quantity, such as for example a causal…

统计方法学 · 统计学 2021-03-05 Michael Schomaker

Inferring causal effects from an observational study is challenging because participants are not randomized to treatment. Observational studies in infectious disease research present the additional challenge that one participant's treatment…

统计方法学 · 统计学 2020-12-25 Brian G. Barkley , Michael G. Hudgens , John D. Clemens , Mohammad Ali , Michael E. Emch

In estimating the causal effect of a continuous exposure or treatment, it is important to control for all confounding factors. However, most existing methods require parametric specification for how control variables influence the outcome…

应用统计 · 统计学 2020-07-21 Spencer Woody , Carlos M. Carvalho , P. Richard Hahn , Jared S. Murray

Measurement error in observational datasets can lead to systematic bias in inferences based on these datasets. As studies based on observational data are increasingly used to inform decisions with real-world impact, it is critical that we…

机器学习 · 统计学 2019-01-29 Roy Adams , Yuelong Ji , Xiaobin Wang , Suchi Saria

Causal inference in connected populations is non-trivial, because the treatment assignments of units can affect the outcomes of other units via treatment and outcome spillover. Since outcome spillover induces dependence among outcomes,…

统计方法学 · 统计学 2025-12-25 Subhankar Bhadra , Michael Schweinberger

In observational studies, causal inference relies on several key identifying assumptions. One identifiability condition is the positivity assumption, which requires the probability of treatment be bounded away from 0 and 1. That is, for…

统计方法学 · 统计学 2022-02-21 Yaqian Zhu , Nandita Mitra , Jason Roy

In randomized trials and observational studies, it is often necessary to evaluate the extent to which an intervention affects a time-to-event outcome, which is only partially observed due to right censoring. For instance, in infectious…

统计方法学 · 统计学 2024-12-16 Yutong Jin , Peter B. Gilbert , Aaron Hudson

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

统计方法学 · 统计学 2018-01-04 Peng Ding , Fan Li

Suppose that a sequence of treatments are assigned to influence an outcome of interest that occurs after the last treatment. Between treatments there exist time-dependent covariates that may be posttreatment variables of the earlier…

统计方法学 · 统计学 2015-05-28 Li Yin , Xiaoqin Wang

This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

统计方法学 · 统计学 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli
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