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Aneurysms are localized bulges of arteries, and they can rupture with fatal consequences. Complex mechanobiological factors preclude in vivo testing to assess the rupture risk of an aneurysm, and size based criteria are often used in…

医学物理 · 物理学 2021-08-26 Masoud Hejazi , A. Srikantha Phani

Mechanical instability in a pre-tensioned finite hyperelastic tube subjected to a slowly increasing internal pressure produces a spatially localized bulge at a critical pressure. The subsequent fate of the bulge, under continued inflation,…

医学物理 · 物理学 2021-01-28 Masoud Hejazi , York Hsiang , A. Srikantha Phani

When a rubber tube with free ends is inflated under volume control, the pressure will first reach a maximum and then decrease monotonically to approach a constant asymptote. The pressure maximum corresponds to the initiation of a localised…

软凝聚态物质 · 物理学 2022-10-12 Zhiming Guo , Shibin Wang , Yibin Fu

We investigate the stability of the deformation modeled by the opening angle method, often used to give a measure of residual stresses in arteries and other biological soft tubular structures. Specifically, we study the influence of…

软凝聚态物质 · 物理学 2020-09-09 Michel Destrade , Irene Lusetti , Robert Mangan , Taisiya Sigaeva

We address the folding induced by differential growth in soft layered solids via an elementary model that consists of a soft growing neo-Hookean elastic layer adhered to a deep elastic substrate. As the layer/substrate modulus ratio is…

软凝聚态物质 · 物理学 2015-09-30 Tuomas Tallinen , John S. Biggins

Rupture of aortic aneurysms is by far the most fatal heart disease, with a mortality rate exceeding 80%. There are no reliable clinical protocols to predict growth, dissection, and rupture because the fundamental physics driving aneurysm…

组织与器官 · 定量生物学 2023-11-02 Tom Y. Zhao , Jin-Tae Kim , Min Cho , Akhil Narang , John A. Rogers , Neelesh A. Patankar

Growth-induced instabilities are ubiquitous in biological systems and lead to diverse morphologies in the form of wrinkling, folding, and creasing. The current work focusses on the mechanics behind growth-induced wrinkling instabilities in…

斑图形成与孤子 · 物理学 2022-06-28 Sumit Mehta , Gangadharan Raju , Prashant Saxena

Growth-induced pattern formations in curved film-substrate structures have attracted extensive attentions recently. In most existing literature, the growth tensor is assumed to be homogeneous or piecewise homogeneous. In this paper, we aim…

斑图形成与孤子 · 物理学 2021-11-10 Rui-Cheng Liu , Yang Liu , Zongxi Cai

The basic mechanism driving aneurysm growth is unknown. Currently, clinical diagnosis of an aneurysm is mainly informed by retrospective tracking of its size and growth rate. However, aneurysms can rupture before reactive criteria are met…

Previous linear bifurcation analyses have evidenced that an axially stretched soft cylindrical tube may develop an infinite-wavelength (localised) instability when one or both of its lateral surfaces are under sufficient surface tension.…

斑图形成与孤子 · 物理学 2021-11-17 Dominic Emery , Yibin Fu

Several experiments have demonstrated the existence of an electro-mechanical effect in many biological tissues and hydrogels, and its actual influence on growth, migration, and pattern formation. Here, to model these interactions and…

软凝聚态物质 · 物理学 2020-07-07 Yangkun Du , Yipin Su , Chaofeng Lu , Weiqiu Chen , Michel Destrade

The experimental actualisation of organoids modelling organs from brains to pancreases has revealed that much of the diverse morphologies of organs are emergent properties of simple intercellular "rules" and not the result of top-down…

组织与器官 · 定量生物学 2019-10-07 Julius B. Kirkegaard , Bjarke F. Nielsen , Ala Trusina , Kim Sneppen

We evaluate the loss of stability of axially compressed slender and thick-walled tubes subject to a residual stress distribution. The nonlinear theory of elasticity, when used to analyze the underlying deformation, shows that the residual…

软凝聚态物质 · 物理学 2025-05-13 Tao Zhang , Luis Dorfmann , Yang Liu

We study theoretically the shapes of biological tubes affected by various pathologies. When epithelial cells grow at an uncontrolled rate, the negative tension produced by their division provokes a buckling instability. Several shapes are…

生物物理 · 物理学 2012-07-09 Edouard Hannezo , Jean-Francois Joanny , Jacques Prost

We propose that the strength of angular momentum transport in accretion discs threaded by net vertical magnetic field is determined by a self-regulation mechanism: the magnetorotational instability (MRI) grows until its own turbulent…

高能天体物理现象 · 物理学 2023-04-18 Mitchell C. Begelman , Philip J. Armitage

In growing plant cells, parallel ordering of microtubules (MTs) along the inner surface of the cell membrane influences the direction of cell expansion and thereby plant morphology. For correct expansion of organs that primarily grow by…

生物物理 · 物理学 2019-09-05 Sven Bachmann , Richard Froese , Eric N Cytrynbaum

We model the formation and evolution of wrinkles in a floating elastic sheet under uniaxial compression. This is a canonical setup in the study of wrinkling, and whilst its static equilibrium configuration is well characterised, its…

流体动力学 · 物理学 2025-10-31 Daniel J. Netherwood , Ben S. Humphries , Connor Robbins , Doireann O'Kiely

Understanding the dynamics of instabilities along fluid-solid interfaces is critical for the efficacy of focused ultrasound therapy tools (e.g., histotripsy) and microcavitation rheometry techniques. Non-uniform pressure fields generated by…

We study the shape, elasticity and fluctuations of the recently predicted (cond-mat/9510172) and subsequently observed (in numerical simulations) (cond-mat/9705059) tubule phase of anisotropic membranes, as well as the phase transitions…

软凝聚态物质 · 物理学 2009-09-25 Leo Radzihovsky , John Toner

This paper presents an experimental investigation on pattern formation and evolution in bilayered tubular organs using swelling deformation of polydimethylsiloxane (PDMS) and aims at supplying a thorough comparison with theoretical and…

软凝聚态物质 · 物理学 2022-02-15 Rui-Cheng Liu , Lishuai Jin , Zongxi Cai , Yang Liu
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