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Analyses of causal mediation often involve exposure-induced confounders or, relatedly, multiple mediators. In such applications, researchers aim to estimate a variety of different quantities, including interventional direct and indirect…

统计方法学 · 统计学 2025-06-18 Jesse Zhou , Geoffrey T. Wodtke

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

统计方法学 · 统计学 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have…

统计理论 · 数学 2012-10-18 Eric J. Tchetgen Tchetgen , Ilya Shpitser

Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

应用统计 · 统计学 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Causal mediation analysis usually requires strong assumptions, such as ignorability of the mediator, which may not hold in many social and scientific studies. Motivated by a multilevel randomized treatment experiment using functional…

应用统计 · 统计学 2017-07-11 Yi Zhao , Xi Luo

Mediation analysis seeks to identify and quantify the paths by which an exposure affects an outcome. Intermediate variables which are effected by the exposure and which effect the outcome are known as mediators. There exists extensive work…

统计方法学 · 统计学 2020-11-13 James P. Long , Ehsan Irajizad , James D. Doecke , Kim-Anh Do , Min Jin Ha

Causal mediation analysis is an important statistical tool to quantify effects transmitted by intermediate variables from a cause to an outcome. There is a gap in mediation analysis methods to handle mixture mediator data that are…

统计方法学 · 统计学 2025-07-22 Meilin Jiang , Seonjoo Lee , A. James O'Malley , Pengfei Li , Zhigang Li

To estimate direct and indirect effects of an exposure on an outcome from observed data strong assumptions about unconfoundedness are required. Since these assumptions cannot be tested using the observed data, a mediation analysis should…

统计理论 · 数学 2018-03-29 Anita Lindmark , Xavier de Luna , Marie Eriksson

Causal mediation analysis is widely used to investigate how causal effects operate through specific pathways linking treatments or exposures to outcomes. Recently, \texttt{crumble} was developed to enable nonparametric estimation of several…

统计方法学 · 统计学 2026-04-14 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Ivan Diaz

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator…

统计方法学 · 统计学 2026-05-19 Yuki Ohnishi , Fan Li

Causal mediation analysis is an important statistical method in social and medical studies, as it can provide insights about why an intervention works and inform the development of future interventions. Currently, most causal mediation…

统计方法学 · 统计学 2016-01-26 Cheng Zheng , David C. Atkins , Melissa A. Lewis , Xiao-Hua Zhou

Causal mediation analysis is routinely conducted by applied researchers in a variety of disciplines. The goal of such an analysis is to investigate alternative causal mechanisms by examining the roles of intermediate variables that lie in…

统计方法学 · 统计学 2010-11-05 Kosuke Imai , Luke Keele , Teppei Yamamoto

To investigate causal mechanisms, causal mediation analysis decomposes the total treatment effect into the natural direct and indirect effects. This paper examines the estimation of the direct and indirect effects in a general treatment…

统计理论 · 数学 2024-01-24 Lukang Huang , Wei Huang , Oliver Linton , Zheng Zhang

Deciding on an appropriate intervention requires a causal model of a treatment, the outcome, and potential mediators. Causal mediation analysis lets us distinguish between direct and indirect effects of the intervention, but has mostly been…

机器学习 · 计算机科学 2023-06-19 Çağlar Hızlı , ST John , Anne Juuti , Tuure Saarinen , Kirsi Pietiläinen , Pekka Marttinen

Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly…

应用统计 · 统计学 2021-02-24 Shuxi Zeng , Stacy Rosenbaum , Elizabeth Archie , Susan Alberts , Fan Li

This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

Causal mediation analysis is used to evaluate direct and indirect causal effects of a treatment on an outcome of interest through an intermediate variable or a mediator.It is difficult to identify the direct and indirect causal effects…

应用统计 · 统计学 2020-01-14 Wei Li , Chunchen Liu , Zhi Geng , John Murray

Mediation analysis is a strategy for understanding the mechanisms by which treatments or interventions affect later outcomes. Mediation analysis is frequently applied in randomized trial settings, but typically assumes: a) that randomized…

统计方法学 · 统计学 2021-12-30 Kara E. Rudolph , Nicholas Williams , Ivan Diaz

A parametric expression for causal natural direct and indirect effects is derived for the setting of a binary outcome with a binary mediator. The proposed effect decomposition does not require the outcome to be rare and generalizes the…

统计方法学 · 统计学 2021-04-13 Marco Doretti , Martina Raggi , Elena Stanghellini

Causal mediation analysis (CMA) is a powerful method to dissect the total effect of a treatment into direct and mediated effects within the potential outcome framework. This is important in many scientific applications to identify the…

机器学习 · 计算机科学 2023-06-14 Ziyang Jiang , Yiling Liu , Michael H. Klein , Ahmed Aloui , Yiman Ren , Keyu Li , Vahid Tarokh , David Carlson
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