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The detection of mitotic figures from different scanners/sites remains an important topic of research, owing to its potential in assisting clinicians with tumour grading. The MItosis DOmain Generalization (MIDOG) challenge aims to test the…

计算机视觉与模式识别 · 计算机科学 2021-09-30 Mostafa Jahanifar , Adam Shephard , Neda Zamani Tajeddin , R. M. Saad Bashir , Mohsin Bilal , Syed Ali Khurram , Fayyaz Minhas , Nasir Rajpoot

Counting of mitotic figures is a fundamental step in grading and prognostication of several cancers. However, manual mitosis counting is tedious and time-consuming. In addition, variation in the appearance of mitotic figures causes a high…

计算机视觉与模式识别 · 计算机科学 2023-09-26 Mostafa Jahanifar , Adam Shephard , Neda Zamanitajeddin , Simon Graham , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

Deep learning has driven significant advances in mitotic figure analysis within computational pathology. In this paper, we present our approach to the Mitosis Domain Generalization (MIDOG) 2025 Challenge, which consists of two distinct…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Shuting Xu , Runtong Liu , Zhixuan Chen , Junlin Hou , Hao Chen

Automated detection of mitotic figures in histopathology images is a challenging task: here, we present the different steps that describe the strategy we applied to participate in the MIDOG 2021 competition. The purpose of the competition…

计算机视觉与模式识别 · 计算机科学 2021-09-28 Maxime W. Lafarge , Viktor H. Koelzer

Domain variability is a common bottle neck in developing generalisable algorithms for various medical applications. Motivated by the observation that the domain variability of the medical images is to some extent compact, we propose to…

图像与视频处理 · 电气工程与系统科学 2021-10-01 Mustaffa Hussain , Ritesh Gangnani , Sasidhar Kadiyala

Mitotic figure detection is a challenging task in digital pathology that has a direct impact on therapeutic decisions. While automated methods often achieve acceptable results under laboratory conditions, they frequently fail in the…

图像与视频处理 · 电气工程与系统科学 2022-01-21 Jakob Dexl , Michaela Benz , Volker Bruns , Petr Kuritcyn , Thomas Wittenberg

Each woman living in the United States has about 1 in 8 chance of developing invasive breast cancer. The mitotic cell count is one of the most common tests to assess the aggressiveness or grade of breast cancer. In this prognosis,…

计算机视觉与模式识别 · 计算机科学 2022-02-18 Robin Elizabeth Yancey

Mitotic figure (MF) detection in histopathology images is challenging due to large variations in slide scanners, staining protocols, tissue types, and the presence of artifacts. This paper presents a collection of training techniques - a…

计算机视觉与模式识别 · 计算机科学 2025-08-28 Christian Marzahl , Brian Napora

Mitotic figures represent a key histoprognostic feature in tumor pathology, providing crucial insights into tumor aggressiveness and proliferation. However, their identification remains challenging, subject to significant inter-observer…

图像与视频处理 · 电气工程与系统科学 2025-10-21 Raphaël Bourgade , Guillaume Balezo , Hana Feki , Lily Monier , Matthieu Blons , Alice Blondel , Delphine Loussouarn , Anne Vincent-Salomon , Thomas Walter

Mitotic figure detection remains a challenging task in computational pathology due to domain variability and morphological complexity. This paper describes our participation in the MIDOG 2025 challenge, focusing on robust mitotic figure…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Euiseop Song , Jaeyoung Park , Jaewoo Park

Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based…

计算机视觉与模式识别 · 计算机科学 2025-11-04 Adinath Dukre , Ankan Deria , Yutong Xie , Imran Razzak

Counting mitotic figures is time-intensive for pathologists and leads to inter-observer variability. Artificial intelligence (AI) promises a solution by automatically detecting mitotic figures while maintaining decision consistency.…

计算机视觉与模式识别 · 计算机科学 2025-09-08 Seungho Choe , Xiaoli Qin , Abubakr Shafique , Amanda Dy , Susan Done , Dimitrios Androutsos , April Khademi

Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in…

Making histopathology image classifiers robust to a wide range of real-world variability is a challenging task. Here, we describe a candidate deep learning solution for the Mitosis Domain Generalization Challenge 2022 (MIDOG) to address the…

图像与视频处理 · 电气工程与系统科学 2023-01-04 Maxime W. Lafarge , Viktor H. Koelzer

The effective localization of mitosis is a critical precursory task for deciding tumor prognosis and grade. Automated mitosis detection through deep learning-oriented image analysis often fails on unseen patient data due to inherent domain…

计算机视觉与模式识别 · 计算机科学 2022-09-20 Tirupati Saketh Chandr , Sahar Almahfouz Nasser , Nikhil Cherian Kurian , Amit Sethi

Automated detection of mitotic figures in histopathology images has seen vast improvements, thanks to modern deep learning-based pipelines. Application of these methods, however, is in practice limited by strong variability of images…

In certain types of cancerous tissue, mitotic count has been shown to be associated with tumor proliferation, poor prognosis, and therapeutic resistance. Due to the high inter-rater variability of mitotic counting by pathologists,…

计算机视觉与模式识别 · 计算机科学 2023-10-12 Ruiwen Ding , James Hall , Neil Tenenholtz , Kristen Severson

The reliable identification of mitotic figures in whole-slide histopathological images remains difficult, owing to their low prevalence, substantial morphological heterogeneity, and the inconsistencies introduced by tissue processing and…

图像与视频处理 · 电气工程与系统科学 2025-09-23 Navya Sri Kelam , Akash Parekh , Saikiran Bonthu , Nitin Singhal

Breast cancer is the most commonly diagnosed cancer worldwide, with over two million new cases each year. During diagnostic tumour grading, pathologists manually count the number of dividing cells (mitotic figures) in biopsy or tumour…

图像与视频处理 · 电气工程与系统科学 2022-01-19 Jack Breen , Kieran Zucker , Nicolas M. Orsi , Nishant Ravikumar
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