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相关论文: Detecting Mitosis against Domain Shift using a Fus…

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The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker as it is a measure for tumor cell proliferation. However, the identification of MFs has a known low inter-rater…

We propose a two-step domain shift-invariant mitosis cell detection method based on Faster RCNN and a convolutional neural network (CNN). We generate various domain-shifted versions of existing histopathology images using a stain…

计算机视觉与模式识别 · 计算机科学 2021-09-29 Ramin Nateghi , Fattaneh Pourakpour

We present a novel approach which extends the existing Fully Convolutional One-Stage Object Detector (FCOS) for mitotic figure detection. Our composite model adds a Feedback Attention Ladder CNN (FAL-CNN) model for classification of normal…

图像与视频处理 · 电气工程与系统科学 2025-09-22 Andrew Broad , Jason Keighley , Lucy Godson , Alex Wright

Atypical mitotic figures (AMFs) are important histopathological markers yet remain challenging to identify consistently, particularly under domain shift stemming from scanner, stain, and acquisition differences. We present a simple…

计算机视觉与模式识别 · 计算机科学 2025-08-29 Kaustubh Atey , Sameer Anand Jha , Gouranga Bala , Amit Sethi

Mitotic counting is a vital prognostic marker of tumor proliferation in breast cancer. Deep learning-based mitotic detection is on par with pathologists, but it requires large labeled data for training. We propose a deep classification…

计算机视觉与模式识别 · 计算机科学 2020-07-03 Pushpak Pati , Antonio Foncubierta-Rodriguez , Orcun Goksel , Maria Gabrani

Mitotic activity is a crucial proliferation biomarker for the diagnosis and prognosis of different types of cancers. Nevertheless, mitosis counting is a cumbersome process for pathologists, prone to low reproducibility, due to the large…

图像与视频处理 · 电气工程与系统科学 2022-12-01 Claudio Fernandez-Martín , Umay Kiraz , Julio Silva-Rodríguez , Sandra Morales , Emiel Janssen , Valery Naranjo

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis…

Mitotic count is the most important morphological feature of breast cancer grading. Many deep learning-based methods have been proposed but suffer from domain shift. In this work, we construct a Fourier-based segmentation model for mitosis…

图像与视频处理 · 电气工程与系统科学 2021-10-20 Sen Yang , Feng Luo , Jun Zhang , Xiyue Wang

Mitotic figure detection in histopathology images remains challenging due to significant domain shifts across different scanners, staining protocols, and tissue types. This paper presents our approach for the MIDOG 2025 challenge Track 1,…

Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…

计算机视觉与模式识别 · 计算机科学 2017-09-08 Marc Aubreville , Maximilian Krappmann , Christof Bertram , Robert Klopfleisch , Andreas Maier

This is the submission for mitosis detection in the context of the MIDOG 2021 challenge. It is based on the two-stage objection model Faster RCNN as well as DenseNet as a backbone for the neural network architecture. It achieves a F1-score…

计算机视觉与模式识别 · 计算机科学 2021-09-03 Michel Halmes , Hippolyte Heuberger , Sylvain Berlemont

Mitotic activity is key for the assessment of malignancy in many tumors. Moreover, it has been demonstrated that the proportion of abnormal mitosis to normal mitosis is of prognostic significance. Atypical mitotic figures (MF) can be…

计算机视觉与模式识别 · 计算机科学 2022-12-13 Marc Aubreville , Jonathan Ganz , Jonas Ammeling , Taryn A. Donovan , Rutger H. J. Fick , Katharina Breininger , Christof A. Bertram

Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect…

Automated detection and classification of mitotic figures especially distinguishing atypical from normal remain critical challenges in computational pathology. We present MitoDetect++, a unified deep learning pipeline designed for the MIDOG…

图像与视频处理 · 电气工程与系统科学 2025-09-08 Esha Sadia Nasir , Jiaqi Lv , Mostafa Jahanifar , Shan E Ahmed Raza

The account of mitotic cells is a key feature in tumor diagnosis. However, due to the variability of mitotic cell morphology, it is a highly challenging task to detect mitotic cells in tumor tissues. At the same time, although advanced deep…

计算机视觉与模式识别 · 计算机科学 2022-08-29 Chen Yang , Wang Ziyue , Fang Zijie , Bian Hao , Zhang Yongbing

Accurate mitotic figure classification is crucial in computational pathology, as mitotic activity informs cancer grading and patient prognosis. Distinguishing atypical mitotic figures (AMFs), which indicate higher tumor aggressiveness, from…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Hana Feki , Alice Blondel , Thomas Walter

Mitotic activity is an important feature for grading several cancer types. Counting mitotic figures (MFs) is a time-consuming, laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading and…

Assessing the Mitotic Count has a known high degree of intra- and inter-rater variability. Computer-aided systems have proven to decrease this variability and reduce labeling time. These systems, however, are generally highly dependent on…

图像与视频处理 · 电气工程与系统科学 2022-03-16 Frauke Wilm , Christian Marzahl , Katharina Breininger , Marc Aubreville

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

图像与视频处理 · 电气工程与系统科学 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

图像与视频处理 · 电气工程与系统科学 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete