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Multi-omics data offer unprecedented insights into complex biological systems, yet their high dimensionality, sparsity, and intricate interactions pose significant analytical challenges. Network-based approaches have advanced multi-omics…

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

神经元与认知 · 定量生物学 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

Vessel dynamics simulation is vital in studying the relationship between geometry and vascular disease progression. Reliable dynamics simulation relies on high-quality vascular meshes. Most of the existing mesh generation methods highly…

图像与视频处理 · 电气工程与系统科学 2024-12-03 Dengqiang Jia , Xinnian Yang , Xiaosong Xiong , Shijie Huang , Feiyu Hou , Li Qin , Kaicong Sun , Kannie Wai Yan Chan , Dinggang Shen

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

神经元与认知 · 定量生物学 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

应用统计 · 统计学 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

图像与视频处理 · 电气工程与系统科学 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

Connected networks are a fundamental structure of neurobiology. Understanding these networks will help us elucidate the neural mechanisms of computation. Mathematically speaking these networks are `graphs' - structures containing objects…

神经元与认知 · 定量生物学 2020-10-20 Carl J. Nelson , Stephen Bonner

Understanding the operation of biological and artificial networks remains a difficult and important challenge. To identify general principles, researchers are increasingly interested in surveying large collections of networks that are…

机器学习 · 统计学 2022-01-14 Alex H. Williams , Erin Kunz , Simon Kornblith , Scott W. Linderman

Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices…

A variety of behaviors like spatial navigation or bodily motion can be formulated as graph traversal problems through cognitive maps. We present a neural network model which can solve such tasks and is compatible with a broad range of…

神经与进化计算 · 计算机科学 2021-10-12 Henry Powell , Mathias Winkel , Alexander V. Hopp , Helmut Linde

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

信号处理 · 电气工程与系统科学 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

Blood vessel networks, represented as 3D graphs, help predict disease biomarkers, simulate blood flow, and aid in synthetic image generation, relevant in both clinical and pre-clinical settings. However, generating realistic vessel graphs…

计算机视觉与模式识别 · 计算机科学 2024-07-09 Chinmay Prabhakar , Suprosanna Shit , Fabio Musio , Kaiyuan Yang , Tamaz Amiranashvili , Johannes C. Paetzold , Hongwei Bran Li , Bjoern Menze

Cardio-cerebrovascular diseases are the leading causes of mortality worldwide, whose accurate blood vessel segmentation is significant for both scientific research and clinical usage. However, segmenting cardio-cerebrovascular structures…

图像与视频处理 · 电气工程与系统科学 2024-04-03 Nazik Elsayed , Yousuf Babiker M. Osman , Cheng Li , Jiong Zhang , Shanshan Wang

The exponential growth of neuroscience literature presents a significant challenge for researchers seeking to efficiently access and utilize relevant information. To address this issue, we introduce the Brain Knowledge Engine (BrainKnow),…

数字图书馆 · 计算机科学 2024-06-07 Cunqing Huangfu , Kang Sun , Yi Zeng , Yuwei Wang , Dongsheng Wang , Zizhe Ruan

Mapping the connectome of the human brain using structural or functional connectivity has become one of the most pervasive paradigms for neuroimaging analysis. Recently, Graph Neural Networks (GNNs) motivated from geometric deep learning…

神经元与认知 · 定量生物学 2022-11-30 Hejie Cui , Wei Dai , Yanqiao Zhu , Xuan Kan , Antonio Aodong Chen Gu , Joshua Lukemire , Liang Zhan , Lifang He , Ying Guo , Carl Yang

Dementia is a progressive neurodegenerative disorder with multiple etiologies, including Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and vascular dementia. Its clinical and biological heterogeneity makes diagnosis and…

机器学习 · 计算机科学 2025-09-24 Niharika Tewari , Nguyen Linh Dan Le , Mujie Liu , Jing Ren , Ziqi Xu , Tabinda Sarwar , Veeky Baths , Feng Xia

The morphology and hierarchy of the vascular systems are essential for perfusion in supporting metabolism. In human retina, one of the most energy-demanding organs, retinal circulation nourishes the entire inner retina by an intricate…

图像与视频处理 · 电气工程与系统科学 2024-02-16 Siyi Chen , Amir H. Kashani , Ji Yi

The intricate morphology of brain vessels poses significant challenges for automatic segmentation models, which usually focus on a single imaging modality. However, accurately treating brain-related conditions requires a comprehensive…

计算机视觉与模式识别 · 计算机科学 2025-10-03 Francesco Galati , Daniele Falcetta , Rosa Cortese , Ferran Prados , Ninon Burgos , Maria A. Zuluaga

Data-driven graph learning models a network by determining the strength of connections between its nodes. The data refers to a graph signal which associates a value with each graph node. Existing graph learning methods either use simplified…

机器学习 · 计算机科学 2020-11-05 Nafiseh Ghoroghchian , David M. Groppe , Roman Genov , Taufik A. Valiante , Stark C. Draper

Endowing brain anatomy, dynamics, and function with a network structure is becoming standard in neuroscience. In its simplest form, a network is a collection of units and relationships between them. The pattern of relations among the units…

神经元与认知 · 定量生物学 2025-07-22 David Papo , Javier M. Buldú