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The widespread availability of large amounts of genomic data on the SARS-CoV-2 virus, as a result of the COVID-19 pandemic, has created an opportunity for researchers to analyze the disease at a level of detail unlike any virus before it.…

机器学习 · 计算机科学 2021-10-20 Zahra Tayebi , Sarwan Ali , Murray Patterson

With the rapid spread of the novel coronavirus (COVID-19) across the globe and its continuous mutation, it is of pivotal importance to design a system to identify different known (and unknown) variants of SARS-CoV-2. Identifying particular…

定量方法 · 定量生物学 2021-10-13 Sarwan Ali , Bikram Sahoo , Naimat Ullah , Alexander Zelikovskiy , Murray Patterson , Imdadullah Khan

With the rapid spread of COVID-19 worldwide, viral genomic data is available in the order of millions of sequences on public databases such as GISAID. This Big Data creates a unique opportunity for analysis towards the research of effective…

机器学习 · 计算机科学 2022-10-14 Sarwan Ali , Babatunde Bello , Zahra Tayebi , Murray Patterson

Genomic surveillance of SARS-CoV-2 has been instrumental in tracking the spread and evolution of the virus during the pandemic. The availability of SARS-CoV-2 molecular sequences isolated from infected individuals, coupled with phylodynamic…

应用统计 · 统计学 2021-08-31 Lorenzo Cappello , Jaehee Kim , Sifan Liu , Julia A. Palacios

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

SARS-CoV-2 is an upper respiratory system RNA virus that has caused over 3 million deaths and infecting over 150 million worldwide as of May 2021. With thousands of strains sequenced to date, SARS-CoV-2 mutations pose significant challenges…

定量方法 · 定量生物学 2021-11-15 Yanyi Ding , Zhiyi Kuang , Yuxin Pei , Jeff Tan , Ziyu Zhang , Joseph Konan

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

基因组学 · 定量生物学 2021-11-16 Sarwan Ali , Murray Patterson

More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at an incredible pace due to recent advances in high-throughput sequencing technologies,…

Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today. Researches on this subject have been focused on analyzing the genetic structure of the virus,…

机器学习 · 计算机科学 2023-04-25 Selcuk Yazar

This paper presents a federated learning (FL) approach to train an AI model for SARS-Cov-2 variant classification. We analyze the SARS-CoV-2 spike sequences in a distributed way, without data sharing, to detect different variants of this…

机器学习 · 计算机科学 2023-11-10 Prakash Chourasia , Taslim Murad , Zahra Tayebi , Sarwan Ali , Imdad Ullah Khan , Murray Patterson

The emerging global infectious COVID-19 coronavirus disease by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) presents critical threats to global public health and the economy since it was identified in late December…

基因组学 · 定量生物学 2020-03-25 Changchuan Yin

Recent outbreaks of infectious diseases have been monitored closely from an epidemiological and microbiological perspective. Extracting from this wealth of data the information that is relevant for the evolution of the pathogen and predict…

种群与进化 · 定量生物学 2024-10-10 Baptiste Filoche , Stefan Hohenegger

Summary: The CoV-Spectrum website supports the identification of new SARS-CoV-2 variants of concern and the tracking of known variants. Its flexible amino acid and nucleotide mutation search allows querying of variants before they are…

种群与进化 · 定量生物学 2021-12-28 Chaoran Chen , Sarah Nadeau , Michael Yared , Philippe Voinov , Ning Xie , Cornelius Roemer , Tanja Stadler

Predicting the future evolutionary trajectory of SARS-CoV-2 remains a critical challenge, particularly due to the pivotal role of spike protein mutations. It is therefore essential to develop evolutionary models capable of continuously…

定量方法 · 定量生物学 2025-10-06 Liaofu Luo , Jun Lv

Early detection and characterization of coronavirus disease (COVID-19), caused by SARS-CoV-2, remain critical for effective clinical response and public-health planning. The global availability of large-scale viral sequence data presents…

机器学习 · 计算机科学 2025-12-12 Sarwan Ali , Taslim Murad

The availability of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus data post-COVID has reached exponentially to an enormous magnitude, opening research doors to analyze its behavior. Various studies are conducted by…

神经与进化计算 · 计算机科学 2025-01-28 Taslim Murad , Prakash Chourasia , Sarwan Ali , Imdad Ullah Khan , Murray Patterson

The emergence of new variants of SARS-CoV-2 is a major concern given their potential impact on the transmissibility and pathogenicity of the virus as well as the efficacy of therapeutic interventions. Here, we predict the mutability of all…

基因组学 · 定量生物学 2022-05-11 Juan Rodriguez-Rivas , Giancarlo Croce , Maureen Muscat , Martin Weigt

The COVID-19 pandemic has profoundly affected global health, driven by the remarkable transmissibility and mutational adaptability of the SARS-CoV-2 virus. Although five variants of concern, Alpha, Beta, Gamma, Delta, and Omicron, have been…

基因组学 · 定量生物学 2026-05-07 Bo Jing , Kai-Rui Zhang , Hong-Li Zeng , Erik Aurell

The amount of sequencing data for SARS-CoV-2 is several orders of magnitude larger than any virus. This will continue to grow geometrically for SARS-CoV-2, and other viruses, as many countries heavily finance genomic surveillance efforts.…

基因组学 · 定量生物学 2023-04-10 Sarwan Ali , Prakash Chourasia , Zahra Tayebi , Babatunde Bello , Murray Patterson

The importance of understanding SARS-CoV-2 evolution cannot be overemphasized. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. We…

种群与进化 · 定量生物学 2021-10-12 Rui Wang , Jiahui Chen , Guo-Wei Wei
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