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Mediation analysis seeks to identify and quantify the paths by which an exposure affects an outcome. Intermediate variables which are effected by the exposure and which effect the outcome are known as mediators. There exists extensive work…

统计方法学 · 统计学 2020-11-13 James P. Long , Ehsan Irajizad , James D. Doecke , Kim-Anh Do , Min Jin Ha

Causal mediation analysis aims to characterize an exposure's effect on an outcome and quantify the indirect effect that acts through a given mediator or a group of mediators of interest. With the increasing availability of measurements on a…

We propose a novel approach for causal mediation analysis based on changes-in-changes assumptions restricting unobserved heterogeneity over time. This allows disentangling the causal effect of a binary treatment on a continuous outcome into…

计量经济学 · 经济学 2020-10-13 Martin Huber , Mark Schelker , Anthony Strittmatter

In mediation analysis, the effect of an exposure (or treatment) on an outcome variable is decomposed into two components: a direct effect, which pertains to an immediate influence of the exposure on the outcome, and an indirect effect,…

统计方法学 · 统计学 2017-10-04 Marco Geraci , Alessandra Mattei

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

统计方法学 · 统计学 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

We propose semi- and non-parametric methods to estimate conditional interventional effects in the setting of two discrete mediators whose causal ordering is unknown. Average interventional indirect effects have been shown to decompose an…

统计方法学 · 统计学 2023-04-19 Max Rubinstein , Zach Branson , Edward H. Kennedy

An important problem in causal inference is to break down the total effect of a treatment on an outcome into different causal pathways and to quantify the causal effect in each pathway. For instance, in causal fairness, the total effect of…

机器学习 · 统计学 2022-01-10 Lu Cheng , Ruocheng Guo , Huan Liu

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator…

统计方法学 · 统计学 2026-05-19 Yuki Ohnishi , Fan Li

Traditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a direct effect of the intervention on the outcome, there is a…

应用统计 · 统计学 2020-08-28 Xizhen Cai , Donna L. Coffman , Megan E. Piper , Runze Li

A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

统计方法学 · 统计学 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

Experiments often include multiple treatments, with the primary goal to compare the causal effects of those treatments. This study focuses on comparing the causal anatomies of multiple treatments through the use of causal mediation…

统计方法学 · 统计学 2019-07-03 Kirk Bansak

The decomposition of the overall effect of a treatment into direct and indirect effects is here investigated with reference to a recursive system of binary random variables. We show how, for the single mediator context, the marginal effect…

统计方法学 · 统计学 2025-11-14 Martina Raggi , Elena Stanghellini , Marco Doretti

With multiple potential mediators on the causal pathway from a treatment to an outcome, we consider the problem of decomposing the effects along multiple possible causal path(s) through each distinct mediator. Under Pearl's path-specific…

统计方法学 · 统计学 2021-02-04 Wen Wei Loh , Beatrijs Moerkerke , Tom Loeys , Stijn Vansteelandt

Although the exposure can be randomly assigned in studies of mediation effects, any form of direct intervention on the mediator is often infeasible. As a result, unmeasured mediator-outcome confounding can seldom be ruled out. We propose…

统计方法学 · 统计学 2021-09-30 BaoLuo Sun , Ting Ye

Proximal causal inference was recently proposed as a framework to identify causal effects from observational data in the presence of hidden confounders for which proxies are available. In this paper, we extend the proximal causal inference…

统计理论 · 数学 2023-01-27 AmirEmad Ghassami , Alan Yang , Ilya Shpitser , Eric Tchetgen Tchetgen

This paper develops methods for estimating the natural direct and indirect effects in causal mediation analysis. The efficient influence function-based estimator (EIF-based estimator) and the inverse probability weighting estimator (IPW…

统计方法学 · 统计学 2025-12-11 Kentaro Kawato

It is often of interest to decompose a total effect of an exposure into the component that acts on the outcome through some mediator and the component that acts independently through other pathways. Said another way, we are interested in…

统计理论 · 数学 2016-01-21 Peng Ding , Tyler J. VanderWeele

In causal analysis, understanding the causal mechanisms through which an intervention or treatment affects an outcome is often of central interest. We propose a test to evaluate (i) whether the causal effect of a treatment that is randomly…

计量经济学 · 经济学 2026-03-05 Martin Huber , Kevin Kloiber , Lukáš Lafférs

There is a growing literature on finding so-called optimal treatment rules, which are rules by which to assign treatment to individuals based on an individual's characteristics, such that a desired outcome is maximized. A related goal…

应用统计 · 统计学 2021-01-22 Kara E. Rudolph , Ivan Diaz

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

统计方法学 · 统计学 2025-06-26 Tianchen Qian