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Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

应用统计 · 统计学 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Analyses of causal mediation often involve exposure-induced confounders or, relatedly, multiple mediators. In such applications, researchers aim to estimate a variety of different quantities, including interventional direct and indirect…

统计方法学 · 统计学 2025-06-18 Jesse Zhou , Geoffrey T. Wodtke

Deciding on an appropriate intervention requires a causal model of a treatment, the outcome, and potential mediators. Causal mediation analysis lets us distinguish between direct and indirect effects of the intervention, but has mostly been…

机器学习 · 计算机科学 2023-06-19 Çağlar Hızlı , ST John , Anne Juuti , Tuure Saarinen , Kirsi Pietiläinen , Pekka Marttinen

Causal mediation analysis examines causal pathways linking exposures to disease. The estimation of interventional effects, which are mediation estimands that overcome certain identifiability problems of natural effects, has been advanced…

统计方法学 · 统计学 2025-04-23 Tong Chen , Stijn Vansteelandt , David Burgner , Toby Mansell , Margarita Moreno-Betancur

Causal mediation analysis is widely used to investigate how causal effects operate through specific pathways linking treatments or exposures to outcomes. Recently, \texttt{crumble} was developed to enable nonparametric estimation of several…

统计方法学 · 统计学 2026-04-14 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Ivan Diaz

This paper aims to provide practitioners of causal mediation analysis with a better understanding of estimation options. We take as inputs two familiar strategies (weighting and model-based prediction) and a simple way of combining them…

Accurate estimation of treatment effects is essential for decision-making across various scientific fields. This task, however, becomes challenging in areas like social sciences and online marketplaces, where treating one experimental unit…

机器学习 · 计算机科学 2025-02-04 Mohsen Bayati , Yuwei Luo , William Overman , Sadegh Shirani , Ruoxuan Xiong

This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

Estimating causal interactions in complex dynamical systems is an important problem encountered in many fields of current science. While a theoretical solution for detecting the causal interactions has been previously formulated in the…

数据分析、统计与概率 · 物理学 2020-01-20 Jakub Kořenek , Jaroslav Hlinka

Predicting the effect of interventions with many possible variations, e.g., therapeutic content that affects mental health outcomes or an earnings call transcript that drives movement in share price, is useful across several domains.…

机器学习 · 计算机科学 2026-05-27 Nikita Dhawan , Arnav Paruthi , Andrew Kim , Lovedeep Gondara , Jekaterina Novikova , Chris J. Maddison

Deep learning models achieve high predictive performance but lack intrinsic interpretability, hindering our understanding of the learned prediction behavior. Existing local explainability methods focus on associations, neglecting the causal…

机器学习 · 计算机科学 2025-09-18 Niklas Penzel , Joachim Denzler

We propose a set of causal estimands that we call the "mediated probabilities of causation." These estimands quantify the probabilities that an observed negative outcome was induced via a mediating pathway versus a direct pathway in a…

统计方法学 · 统计学 2025-02-14 Max Rubinstein , Maria Cuellar , Daniel Malinsky

Causal mediation analysis is used to evaluate direct and indirect causal effects of a treatment on an outcome of interest through an intermediate variable or a mediator.It is difficult to identify the direct and indirect causal effects…

应用统计 · 统计学 2020-01-14 Wei Li , Chunchen Liu , Zhi Geng , John Murray

Causal mediation analysis in cluster-randomized trials (CRTs) is complicated by the presence of multiple mediators, intracluster correlation, and within-cluster interference. Existing mediation methods often fall short in accommodating…

统计方法学 · 统计学 2026-04-14 Jiaqi Tong , Chao Cheng , Fan Li

We study the problem of efficiently estimating the effect of an intervention on a single variable (atomic interventions) using observational samples in a causal Bayesian network. Our goal is to give algorithms that are efficient in both…

机器学习 · 计算机科学 2020-08-07 Arnab Bhattacharyya , Sutanu Gayen , Saravanan Kandasamy , Ashwin Maran , N. V. Vinodchandran

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

统计方法学 · 统计学 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

We consider assessing causal mediation in the presence of a post-treatment event (examples include noncompliance, a clinical event, or death). We identify natural mediation effects for the entire study population and for each principal…

统计方法学 · 统计学 2024-09-13 Chao Cheng , Fan Li

Mediation analysis seeks to identify and quantify the paths by which an exposure affects an outcome. Intermediate variables which are effected by the exposure and which effect the outcome are known as mediators. There exists extensive work…

统计方法学 · 统计学 2020-11-13 James P. Long , Ehsan Irajizad , James D. Doecke , Kim-Anh Do , Min Jin Ha

In cluster-randomized trials (CRTs), there is emerging interest in exploring the causal mechanism in which a cluster-level treatment affects the outcome through an intermediate outcome. The majority of existing causal mediation methods are…

统计方法学 · 统计学 2026-01-12 Chao Cheng , Fan Li

Mediation analysis is a strategy for understanding the mechanisms by which treatments or interventions affect later outcomes. Mediation analysis is frequently applied in randomized trial settings, but typically assumes: a) that randomized…

统计方法学 · 统计学 2021-12-30 Kara E. Rudolph , Nicholas Williams , Ivan Diaz
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