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This paper examines synchronization of computer clocks connected via a data network and proposes a skewless algorithm to synchronize them. Unlike existing solutions, which either estimate and compensate the frequency difference (skew) among…

最优化与控制 · 数学 2014-07-29 Enrique Mallada , Xiaoqiao Meng , Michel Hack , Li Zhang , Ao Tang

One of the key phenomena in the adaptive immune response to infection and immunization is affinity maturation, during which antibody genes are mutated and selected, typically resulting in a substantial increase in binding affinity to the…

定量方法 · 定量生物学 2013-03-05 Thomas B. Kepler

Transfer learning (TL) has emerged as a powerful tool to supplement data collected for a target task with data collected for a related source task. The Bayesian framework is natural for TL because information from the source data can be…

统计方法学 · 统计学 2024-06-06 Mohamed A. Abba , Jonathan P. Williams , Brian J. Reich

Atomic clocks are crucial for science and technology, but their sensitivity is often restricted by the standard quantum limit. To surpass this limit, correlations between particles or interrogation times must be leveraged. Although the…

量子物理 · 物理学 2024-10-28 Chengyin Han , Zhu Ma , Yuxiang Qiu , Ruihuan Fang , Jiatao Wu , Chang Zhan , Maojie Li , Jiahao Huang , Bo Lu , Chaohong Lee

This paper introduces a flexible regularization approach that reduces point estimation risk of group means stemming from e.g. categorical regressors, (quasi-)experimental data or panel data models. The loss function is penalized by adding…

计量经济学 · 经济学 2019-01-08 Phillip Heiler , Jana Mareckova

Many real-life applications involve estimation of curves that exhibit complicated shapes including jumps or varying-frequency oscillations. Practical methods have been devised that can adapt to a locally varying complexity of an unknown…

统计理论 · 数学 2021-05-28 Veronika Rockova , Judith Rousseau

Gene gain-loss-duplication models are commonly based on continuous-time birth-death processes. Employed in a phylogenetic context, such models have been increasingly popular in studies of gene content evolution across multiple genomes.…

种群与进化 · 定量生物学 2021-07-27 Miklos Csuros

Researchers and managers model ecological communities to infer the biotic and abiotic variables that shape species' ranges, habitat use, and co-occurrence which, in turn, are used to support management decisions and test ecological…

应用统计 · 统计学 2020-06-01 Trevor Hefley

We develop a fully Bayesian framework for function-on-scalars regression with many predictors. The functional data response is modeled nonparametrically using unknown basis functions, which produces a flexible and data-adaptive functional…

统计方法学 · 统计学 2018-10-25 Daniel R. Kowal , Daniel C. Bourgeois

The reconstruction of a species phylogeny from genomic data faces two significant hurdles: 1) the trees describing the evolution of each individual gene--i.e., the gene trees--may differ from the species phylogeny and 2) the molecular…

机器学习 · 计算机科学 2017-07-17 Gautam Dasarathy , Elchanan Mossel , Robert Nowak , Sebastien Roch

We derive tractable criteria for the consistency of Bayesian tree reconstruction procedures, which constitute a central class of algorithms for inferring common ancestry among DNA sequence samples in phylogenetics. Our results encompass…

统计理论 · 数学 2025-08-05 Alisa Kirichenko , Luke J. Kelly , Jere Koskela

In the small phylogeny problem we, are given a phylogenetic tree and gene orders of the extant species and our goal is to reconstruct all of the ancestral genomes so that the number of evolutionary operations is minimized. Algorithms for…

种群与进化 · 定量生物学 2015-03-17 Jakub Kováč , Broňa Brejová , Tomáš Vinař

A 'Winner's Curse' arises in large-scale online experimentation platforms when the same experiments are used to both select treatments and evaluate their effects. In these settings, classical difference-in-means estimators of treatment…

统计方法学 · 统计学 2025-11-11 Richard Mudd , Rina Friedberg , Ilya Gorbachev , Houssam Nassif , Abbas Zaidi

Bayesian inference for models that have an intractable partition function is known as a doubly intractable problem, where standard Monte Carlo methods are not applicable. The past decade has seen the development of auxiliary variable Monte…

统计计算 · 统计学 2017-10-13 Richard G. Everitt , Dennis Prangle , Philip Maybank , Mark Bell

In high dimensional regression, global local shrinkage priors have gained significant traction for their ability to yield sparse estimates, improve parameter recovery, and support accurate predictive modeling. While recent work has explored…

统计方法学 · 统计学 2025-05-19 Javier Enrique Aguilar , Paul-Christian Bürkner

Modeling the time evolution of discrete sets of items (e.g., genetic mutations) is a fundamental problem in many biomedical applications. We approach this problem through the lens of continuous-time Markov chains, and show that the…

机器学习 · 计算机科学 2021-07-08 Alkis Gotovos , Rebekka Burkholz , John Quackenbush , Stefanie Jegelka

Inferential summaries of tree estimates are useful in the setting of evolutionary biology, where phylogenetic trees have been built from DNA data since the 1960's. In bioinformatics, psychometrics and data mining, hierarchical clustering…

应用统计 · 统计学 2010-06-08 John Chakerian , Susan Holmes

One of the standardized features of financial data is that log-returns are uncorrelated, but absolute log-returns or their squares namely the fluctuating volatility are correlated and is characterized by heavy tailed in the sense that some…

统计金融 · 定量金融 2021-05-11 Geoffrey Ducournau

The block maxima method in extreme value theory consists of fitting an extreme value distribution to a sample of block maxima extracted from a time series. Traditionally, the maxima are taken over disjoint blocks of observations.…

统计理论 · 数学 2018-02-28 Axel Bücher , Johan Segers

Determination of functions for poorly characterized genes is crucial for understanding biological processes and studying human diseases. Functionally associated genes are often gained and lost together through evolution. Therefore…

应用统计 · 统计学 2018-08-21 Yang Li , Shaoyang Ning , Sarah E. Calvo , Vamsi K. Mootha , Jun S. Liu