相关论文: Morphologies of compressed active epithelial monol…
Several experiments have demonstrated the existence of an electro-mechanical effect in many biological tissues and hydrogels, and its actual influence on growth, migration, and pattern formation. Here, to model these interactions and…
We explore the behavior of spatially heterogeneous elastic moduli as well as the correlations between local moduli in model solids with short-range repulsive potentials. We show through numerical simulations that local elastic moduli…
Quantifying the in-plane rheology of epithelial monolayers remains challenging due to the difficulty of imposing controlled shear. We introduce a self-driven, rheometer-like assay in which collective migration generates stationary shear…
Viewed under a fluorescence microscope, the actomyosin cytoskeleton presents vivid streaks of lines together with persistent oscillatory waves. Using an active hydrodynamic approach, we show how a uniform distribution of single or mixture…
We report experimental observations of an undulational instability of myelin figures. Motivated by this, we examine theoretically the deformation and possible instability of concentric, cylindrical, multi-lamellar membrane structures. Under…
Collective cell migration plays a crucial role in many developmental processes that underlie morphogenesis, wound healing, or cancer progression. In such coordinated behaviours, cells are organised in coherent structures and actively…
Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a key parameter of the theory-is not well established…
The rheology of biological tissue plays an important role in many processes, from organ formation to cancer invasion. Here, we use a multi-phase field model of motile cells to simulate active microrheology within a tissue monolayer. When…
Tissue fusion eliminates physical voids in a tissue to form a continuous structure and is central to many processes in development and repair. Fusion events in vivo, particularly in embryonic development, often involve the purse-string…
Convergent extension of epithelial tissue is a key motif of animal morphogenesis. On a coarse scale, cell motion resembles laminar fluid flow; yet in contrast to a fluid, epithelial cells adhere to each other and maintain the tissue layer…
Bilayers, soft substrates coated with stiff films, are commonly found in nature with examples including skin tissue, vesicles, and organ membranes. They exhibit different types of instabilities when subjected to compression, depending on…
Toroidal modes in the form of so-called Hopfions, with two independent winding numbers, a hidden one (twist, s), which characterizes a circular vortex thread embedded into a three-dimensional soliton, and the vorticity around the vertical…
Topological defects are increasingly being identified in various biological systems, where their characteristic flow fields and stress patterns are associated with continuous active stress generation by biological entities. Here, using…
The motion of cells in tissues is an ubiquitous phenomenon. In particular, in monolayered cell colonies in vitro, pronounced collective behavior with swirl-like motion has been observed deep within a cell colony, while at the same time, the…
The edges of torn plastic sheets and growing leaves often display hierarchical buckling patterns. We show that this complex morphology (i) emerges even in zero strain configurations, and (ii) is driven by a competition between the two…
A famous and thoroughly investigated instability set-up, susceptible to wrinkling and creasing, consists of an elastic half-space being prestressed under a dead load, applied at infinity and, possibly, on its surface. We consider the case…
In cell extrusion, a cell embedded in an epithelial monolayer loses its apical or basal surface and is subsequently squeezed out of the monolayer by neighboring cells. Cell extrusions occur during apoptosis, epithelial-mesenchymal…
Particles trapped at a fluid-fluid interface by capillary forces can form a monolayer that jams and buckles when subject to uni-axial compression. Here we investigate experimentally the buckling mechanics of monolayers of millimeter-sized…
Both animal and plant tissue exhibit a nonlinear rheological phenomenon known as compression stiffening, or an increase in moduli with increasing uniaxial compressive strain. Does such a phenomenon exist in single cells, which are the…
Polar patterns and topological defects are ubiquitous in active matter. In this paper, we study a paradigmatic polar active dumbbell system through numerical simulations, to clarify how polar patterns and defects emerge and shape evolution.…