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Facing a global epidemic of new infectious diseases such as COVID-19, non-pharmaceutical interventions (NPIs), which reduce transmission rates without medical actions, are being implemented around the world to mitigate spreads. One of the…

种群与进化 · 定量生物学 2021-03-04 Naoya Fujiwara , Tomokatsu Onaga , Takayuki Wada , Shouhei Takeuchi , Junji Seto , Tomoki Nakaya , Kazuyuki Aihara

We provide an approach to exploratory data analysis in matched observational studies with a single intervention and multiple endpoints. In such settings, the researcher would like to explore evidence for actual treatment effects among these…

统计方法学 · 统计学 2025-12-10 Mengqi Lin , Colin Fogarty

We propose a compartmental model for vector-transmitted diseases, such as Malaria and Dengue, spreading over complex networks. Individuals are represented by independent random walkers and vectors by infected nodes. Both walkers and nodes…

种群与进化 · 定量生物学 2025-05-05 Téo Granger , Thomas M. Michelitsch , Bernard A. Collet , Michael Bestehorn , Alejandro P. Riascos

Many research questions in public health and medicine concern sustained interventions in populations defined by substantive priorities. Existing methods to answer such questions typically require a measured covariate set sufficient to…

统计方法学 · 统计学 2023-06-30 Audrey Renson , Michael Hudgens , Alexander Keil , Paul Zivich , Allison Aiello

In this paper, we propose a realistic mathematical model taking into account the mutual interference among the interacting populations. This model attempts to describe the control (vaccination) function as a function of the number of…

神经与进化计算 · 计算机科学 2016-11-18 V. Sree Hari Rao , M. Naresh Kumar

It has recently become popular to define treatment effects for subsets of the target population characterized by variables not observable at the time a treatment decision is made. Characterizing and estimating such treatment effects is…

统计理论 · 数学 2007-08-30 Marshall M. Joffe , Dylan Small , Chi-Yuan Hsu

We consider a potential outcomes model in which interference may be present between any two units but the extent of interference diminishes with spatial distance. The causal estimand is the global average treatment effect, which compares…

统计方法学 · 统计学 2022-09-16 Michael P. Leung

Bipartite experiments are a recent object of study in causal inference, whereby treatment is applied to one set of units and outcomes of interest are measured on a different set of units. These experiments are particularly useful in…

This paper provides a solution to the evaluation of treatment effects in selective samples when neither instruments nor parametric assumptions are available. We provide sharp bounds for average treatment effects under a conditional…

计量经济学 · 经济学 2024-12-17 Phillip Heiler , Asbjørn Kaufmann , Bezirgen Veliyev

Observational studies of treatment effects require adjustment for confounding variables. However, causal inference methods typically cannot deliver perfect adjustment on all measured baseline variables, and there is often ambiguity about…

统计方法学 · 统计学 2024-02-16 Lauren D. Liao , Yeyi Zhu , Amanda L. Ngo , Rana F. Chehab , Samuel D. Pimentel

No unmeasured confounding is often assumed in estimating treatment effects in observational data when using approaches such as propensity scores and inverse probability weighting. However, in many such studies due to the limitation of the…

应用统计 · 统计学 2019-08-06 Rong Huang , Ronghui Xu , Parambir S. Dulai

We describe our framework, deployed at Facebook, that accounts for interference between experimental units through cluster-randomized experiments. We document this system, including the design and estimation procedures, and detail insights…

社会与信息网络 · 计算机科学 2020-12-17 Brian Karrer , Liang Shi , Monica Bhole , Matt Goldman , Tyrone Palmer , Charlie Gelman , Mikael Konutgan , Feng Sun

Individual-based models of contagious processes are useful for predicting epidemic trajectories and informing intervention strategies. In such models, the incorporation of contact network information can capture the non-randomness and…

种群与进化 · 定量生物学 2023-11-09 Maxwell H. Wang , Jukka-Pekka Onnela

In this paper, we present a new way of matching in observational studies that overcomes three limitations of existing matching approaches. First, it directly balances covariates with multi-valued treatments without requiring the generalized…

应用统计 · 统计学 2019-07-11 Magdalena Bennett , Juan Pablo Vielma , Jose R. Zubizarreta

The principal stratification has become a popular tool to address a broad class of causal inference questions, particularly in dealing with non-compliance and truncation-by-death problems. The causal effects within principal strata which…

统计方法学 · 统计学 2022-06-20 Shanshan Luo , Wei Li , Wang Miao , Yangbo He

Composite endpoints are commonly used with an anticipation that clinically relevant endpoints as a whole would yield meaningful treatment benefits. The win ratio is a rank-based statistic to summarize composite endpoints, allowing…

统计方法学 · 统计学 2022-12-14 Di Zhang , Stephen R. Wisniewski , Jong-Hyeon Jeong

Unmeasured confounding presents a significant challenge in causal inference from observational studies. Classical approaches often rely on collecting proxy variables, such as instrumental variables. However, in applications where the…

统计方法学 · 统计学 2025-01-16 Xiaochuan Shi , Dehan Kong , Linbo Wang

Causal inference concerns not only the average effect of the treatment on the outcome but also the underlying mechanism through an intermediate variable of interest. Principal stratification characterizes such a mechanism by targeting…

统计方法学 · 统计学 2022-03-29 Zhichao Jiang , Shu Yang , Peng Ding

In cluster-randomized trials (CRTs), there is emerging interest in exploring the causal mechanism in which a cluster-level treatment affects the outcome through an intermediate outcome. The majority of existing causal mediation methods are…

统计方法学 · 统计学 2026-01-12 Chao Cheng , Fan Li

Environmental epidemiologists are increasingly interested in establishing causality between exposures and health outcomes. A popular model for causal inference is the Rubin Causal Model (RCM), which typically seeks to estimate the average…

应用统计 · 统计学 2021-01-26 Keith W. Zirkle , Marie-Abele Bind , Jenise L. Swall , David C. Wheeler