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The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

计算机视觉与模式识别 · 计算机科学 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold…

计算机视觉与模式识别 · 计算机科学 2023-10-05 Amaya Gallagher-Syed , Luca Rossi , Felice Rivellese , Costantino Pitzalis , Myles Lewis , Michael Barnes , Gregory Slabaugh

Histopathology slides are routinely marked by pathologists using permanent ink markers that should not be removed as they form part of the medical record. Often tumour regions are marked up for the purpose of highlighting features or other…

计算机视觉与模式识别 · 计算机科学 2019-05-14 Sharib Ali , Nasullah Khalid Alham , Clare Verrill , Jens Rittscher

Accurate prediction of placental diseases via whole slide images (WSIs) is critical for preventing severe maternal and fetal complications. However, WSI analysis presents significant computational challenges due to the massive data volume.…

计算机视觉与模式识别 · 计算机科学 2025-08-06 Hang Guo , Qing Zhang , Zixuan Gao , Siyuan Yang , Shulin Peng , Xiang Tao , Ting Yu , Yan Wang , Qingli Li

Histopathological image segmentation is a laborious and time-intensive task, often requiring analysis from experienced pathologists for accurate examinations. To reduce this burden, supervised machine-learning approaches have been adopted…

计算机视觉与模式识别 · 计算机科学 2024-09-12 Vishnuvardhan Purma , Suhas Srinath , Seshan Srirangarajan , Aanchal Kakkar , Prathosh A. P

Accurate and efficient registration of whole slide images (WSIs) is essential for high-resolution, nuclei-level analysis in multi-stained tissue slides. We propose a novel coarse-to-fine framework CORE for accurate nuclei-level registration…

We present a novel weakly-supervised framework for classifying whole slide images (WSIs). WSIs, due to their gigapixel resolution, are commonly processed by patch-wise classification with patch-level labels. However, patch-level labels…

计算机视觉与模式识别 · 计算机科学 2022-03-10 Tiange Xiang , Yang Song , Chaoyi Zhang , Dongnan Liu , Mei Chen , Fan Zhang , Heng Huang , Lauren O'Donnell , Weidong Cai

Whole Slide Images (WSIs) exhibit hierarchical structure, where diagnostic information emerges from cellular morphology, regional tissue organization, and global context. Existing Computational Pathology (CPath) Multimodal Large Language…

We focus on tertiary lymphoid structure (TLS) semantic segmentation in whole slide image (WSI). Unlike TLS binary segmentation, TLS semantic segmentation identifies boundaries and maturity, which requires integrating contextual information…

计算机视觉与模式识别 · 计算机科学 2024-12-10 Lei Su , Yang Du

Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images…

图像与视频处理 · 电气工程与系统科学 2024-10-03 Sitong Liu , Kechun Liu , Samuel Margolis , Wenjun Wu , Stevan R. Knezevich , David E Elder , Megan M. Eguchi , Joann G Elmore , Linda Shapiro

Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. The gigapixel size of WSIs necessitates the use of sliding window methodology for nucleus detection. However, mainstream…

图像与视频处理 · 电气工程与系统科学 2026-02-10 Zhongyi Shui , Honglin Li , Yunlong Zhang , Yuxuan Sun , Yiwen Ye , Pingyi Chen , Ruizhe Guo , Lei Cui , Chenglu Zhu , Lin Yang

The condition of the Glomeruli, or filter sacks, in renal Direct Immunofluorescence (DIF) specimens is a critical indicator for diagnosing kidney diseases. A digital pathology system which digitizes a glass histology slide into a Whole…

计算机视觉与模式识别 · 计算机科学 2019-09-24 Can Peng , Kun Zhao , Arnold Wiliem , Teng Zhang , Peter Hobson , Anthony Jennings , Brian C. Lovell

This study introduces a new framework for the artificial intelligence-assisted characterization of Gram-stained whole-slide images (WSIs). As a test for the diagnosis of bloodstream infections, Gram stains provide critical early data to…

图像与视频处理 · 电气工程与系统科学 2024-09-30 Jack McMahon , Naofumi Tomita , Elizabeth S. Tatishev , Adrienne A. Workman , Cristina R Costales , Niaz Banaei , Isabella W. Martin , Saeed Hassanpour

Tumor segmentation in whole-slide images of histology slides is an important step towards computer-assisted diagnosis. In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles…

计算机视觉与模式识别 · 计算机科学 2018-05-11 Talha Qaiser , Yee-Wah Tsang , Daiki Taniyama , Naoya Sakamoto , Kazuaki Nakane , David Epstein , Nasir Rajpoot

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

计算机视觉与模式识别 · 计算机科学 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

From the simple measurement of tissue attributes in pathology workflow to designing an explainable diagnostic/prognostic AI tool, access to accurate semantic segmentation of tissue regions in histology images is a prerequisite. However,…

图像与视频处理 · 电气工程与系统科学 2021-08-31 Mostafa Jahanifar , Neda Zamani Tajeddin , Navid Alemi Koohbanani , Nasir Rajpoot

Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area. In this paper, we present context-aware stacked convolutional neural networks…

Medical image segmentation assists in computer-aided diagnosis, surgeries, and treatment. Digitize tissue slide images are used to analyze and segment glands, nuclei, and other biomarkers which are further used in computer-aided medical…

图像与视频处理 · 电气工程与系统科学 2022-09-05 Saad Wazir , Muhammad Moazam Fraz

Automatic medical image segmentation via convolutional neural networks (CNNs) has shown promising results. However, they may not always be robust enough for clinical use. Sub-optimal segmentation would require clinician's to manually…

图像与视频处理 · 电气工程与系统科学 2021-10-26 Helena Williams , João Pedrosa , Laura Cattani , Susanne Housmans , Tom Vercauteren , Jan Deprest , Jan D'hooge

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang