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Whole Slide Image (WSI) analysis, with its ability to reveal detailed tissue structures in magnified views, plays a crucial role in cancer diagnosis and prognosis. Due to their giga-sized nature, WSIs require substantial storage and…

计算机视觉与模式识别 · 计算机科学 2025-08-05 Doanh Cao Bui , Jin Tae Kwak

In recent years, the availability of digitized Whole Slide Images (WSIs) has enabled the use of deep learning-based computer vision techniques for automated disease diagnosis. However, WSIs present unique computational and algorithmic…

图像与视频处理 · 电气工程与系统科学 2021-06-15 Yash Sharma , Aman Shrivastava , Lubaina Ehsan , Christopher A. Moskaluk , Sana Syed , Donald E. Brown

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

图像与视频处理 · 电气工程与系统科学 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Computational pathology involves the digitization of stained tissues into whole-slide images (WSIs) that contain billions of pixels arranged as contiguous patches. Statistical analysis of WSIs largely focuses on classification via multiple…

计算机视觉与模式识别 · 计算机科学 2026-03-24 So Won Jeong , Veronika Ročková

Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in…

计算机视觉与模式识别 · 计算机科学 2024-06-10 Hao Wang , Euijoon Ahn , Jinman Kim

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

计算机视觉与模式识别 · 计算机科学 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon

Accurate survival prediction from histopathology whole-slide images (WSIs) remains challenging due to their gigapixel resolution, strong spatial heterogeneity, and complex survival distributions. We introduce a comprehensive computational…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Ardhendu Sekhar , Vasu Soni , Keshav Aske , Shivam Madnoorkar , Pranav Jeevan , Amit Sethi

Diagnostic, prognostic and therapeutic decision-making of cancer in pathology clinics can now be carried out based on analysis of multi-gigapixel tissue images, also known as whole-slide images (WSIs). Recently, deep convolutional neural…

图像与视频处理 · 电气工程与系统科学 2022-09-08 Quoc Dang Vu , Kashif Rajpoot , Shan E Ahmed Raza , Nasir Rajpoot

The segmentation and automatic identification of histological regions of diagnostic interest offer a valuable aid to pathologists. However, segmentation methods are hampered by the difficulty of obtaining pixel-level annotations, which are…

图像与视频处理 · 电气工程与系统科学 2023-02-02 Pushpak Pati , Guillaume Jaume , Zeineb Ayadi , Kevin Thandiackal , Behzad Bozorgtabar , Maria Gabrani , Orcun Goksel

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

计算机视觉与模式识别 · 计算机科学 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Segmentation has long been essential in computer vision due to its numerous real-world applications. However, most traditional deep learning and machine learning models need help to capture geometric features such as size and convexity of…

图像与视频处理 · 电气工程与系统科学 2024-12-02 Huy Trinh , Khang Tran , Nam Nguyen , Tri Cao , Binh Nguyen

DeeperHistReg is a software framework dedicated to registering whole slide images (WSIs) acquired using multiple stains. It allows one to perform the preprocessing, initial alignment, and nonrigid registration of WSIs acquired using…

图像与视频处理 · 电气工程与系统科学 2024-04-24 Marek Wodzinski , Niccolò Marini , Manfredo Atzori , Henning Müller

Digital pathology images play a crucial role in medical diagnostics, but their ultra-high resolution and large file sizes pose significant challenges for storage, transmission, and real-time visualization. To address these issues, we…

计算机视觉与模式识别 · 计算机科学 2025-04-02 SeonYeong Lee , EonSeung Seong , DongEon Lee , SiYeoul Lee , Yubin Cho , Chunsu Park , Seonho Kim , MinKyung Seo , YoungSin Ko , MinWoo Kim

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

图像与视频处理 · 电气工程与系统科学 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Federated learning (FL) has emerged as a promising approach for collaborative medical image analysis, enabling multiple institutions to build robust predictive models while preserving sensitive patient data. In the context of Whole Slide…

图像与视频处理 · 电气工程与系统科学 2025-06-19 Haolong Jin , Shenglin Liu , Cong Cong , Qingmin Feng , Yongzhi Liu , Lina Huang , Yingzi Hu

Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently…

计算机视觉与模式识别 · 计算机科学 2016-03-10 Le Hou , Dimitris Samaras , Tahsin M. Kurc , Yi Gao , James E. Davis , Joel H. Saltz

Objective: The exchange of health-related data is subject to regional laws and regulations, such as the General Data Protection Regulation (GDPR) in the EU or the Health Insurance Portability and Accountability Act (HIPAA) in the United…

计算机与社会 · 计算机科学 2024-01-24 Tom Bisson , Michael Franz , Isil Dogan O , Daniel Romberg , Christoph Jansen , Peter Hufnagl , Norman Zerbe

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level…

计算机视觉与模式识别 · 计算机科学 2025-08-21 Sofiène Boutaj , Marin Scalbert , Pierre Marza , Florent Couzinie-Devy , Maria Vakalopoulou , Stergios Christodoulidis

Whole Slide Images (WSIs) in histopathology pose a significant challenge for extensive medical image analysis due to their ultra-high resolution, massive scale, and intricate spatial relationships. Although existing Multiple Instance…

计算机视觉与模式识别 · 计算机科学 2025-08-05 Jiaxuan Lu , Yuhui Lin , Junyan Shi , Fang Yan , Dongzhan Zhou , Yue Gao , Xiaosong Wang

In digital pathology, the multiple instance learning (MIL) strategy is widely used in the weakly supervised histopathology whole slide image (WSI) classification task where giga-pixel WSIs are only labeled at the slide level. However,…

图像与视频处理 · 电气工程与系统科学 2024-03-28 Zhan Shi , Jingwei Zhang , Jun Kong , Fusheng Wang