相关论文: KwARG: Parsimonious reconstruction of ancestral re…

We present a data structure called a history graph that offers a practical basis for the analysis of genome evolution. It conceptually simplifies the study of parsimonious evolutionary histories by representing both substitutions and double…

Recombination is a powerful evolutionary process that shapes the genetic diversity observed in the populations of many species. Reconstructing genealogies in the presence of recombination from sequencing data is a very challenging problem,…

The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence and recombination events in the history of the sample.…

In the presence of recombination, the evolutionary relationships between a set of sampled genomes cannot be described by a single genealogical tree. Instead, the genomes are related by a complex, interwoven collection of genealogies…

There is little debate about the importance of the ancestral recombination graph in population genetics. An important theoretical tool, the main obstacle to its widespread usage is the computational cost required to match the…

Genetic algorithms are heuristic optimization techniques inspired by Darwinian evolution, which are characterized by successfully finding robust solutions for optimization problems. Here, we propose a subroutine-based quantum genetic…

Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent breakthroughs in simulation and inference…

Inference of the marginal likelihood of sample allele configurations using backward algorithms yields identical results with the Kingman coalescent, the Moran model, and the diffusion model (up to a scaling of time). For inference of…

Ancestral recombination graphs (ARGs) encode the complete genealogical history of a population of recombining lineages. ARGs, and their succinct representation, tree sequences, are increasingly central to modern population genetics methods,…

This paper introduces a new family of multi-parent recombination operators for Genetic Algorithms (GAs), based on normalized Pascal (binomial) coefficients. Unlike classical two-parent crossover operators, Pascal-Weighted Recombination…

We introduce an evolutionary algorithm called recombinator-$k$-means for optimizing the highly non-convex kmeans problem. Its defining feature is that its crossover step involves all the members of the current generation, stochastically…

Large Language Models (LLMs) excel at code generation but struggle with complex problems. Retrieval-Augmented Generation (RAG) mitigates this issue by integrating external knowledge, yet retrieval models often miss relevant context, and…

Retrieval-Augmented Generation (RAG) enhances language models by grounding responses in external information, yet explainability remains a critical challenge, particularly when retrieval relies on unstructured text. Knowledge graphs (KGs)…

Cartesian Genetic Programming has traditionally been using mutation as its main and often sole genetic operator to drive evolutionary search. Despite advancements in recent years, recombinationbased approaches have long been avoided, due to…

The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene…

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

The ancestral recombination graph (ARG) is the model of choice in statistical genetics to model population ancestries. Software capable of simulating ARGs on a genome scale within a reasonable amount of time are now widely available for…

Retrieval-augmented generation (RAG) has emerged as a promising technology for addressing hallucination issues in the responses generated by large language models (LLMs). Existing studies on RAG primarily focus on applying semantic-based…

Knowledge graphs (KGs), with their structured representation capabilities, offer promising avenue for enhancing Retrieval Augmented Generation (RAG) systems, leading to the development of KG-RAG systems. Nevertheless, existing methods often…

Genome-Wide Association Studies (GWAS) identify associations between genetic variants and disease; however, moving beyond associations to causal mechanisms is critical for therapeutic target prioritization. The recently proposed Knowledge…