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Although the exposure can be randomly assigned in studies of mediation effects, any form of direct intervention on the mediator is often infeasible. As a result, unmeasured mediator-outcome confounding can seldom be ruled out. We propose…

统计方法学 · 统计学 2021-09-30 BaoLuo Sun , Ting Ye

Most of the literature on direct and indirect effects assumes that there are no post-treatment common causes of the mediator and the outcome. In contrast to natural direct and indirect effects, organic direct and indirect effects, which…

统计方法学 · 统计学 2020-07-10 Judith J Lok

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

统计方法学 · 统计学 2025-06-26 Tianchen Qian

We consider linear structural equation models with explicitly modelled latent variables. In such models, observed and latent variables solve linear equations including stochastic noise terms. The goal of our work is to identify the direct…

统计方法学 · 统计学 2026-05-28 Tom Hochsprung , Nils Sturma , Jakob Runge , Mathias Drton , Andreas Gerhardus

Instrumental variable methods are widely used for inferring the causal effect in the presence of unmeasured confounders. Existing instrumental variable methods for nonlinear outcome models require stringent identifiability conditions. This…

统计方法学 · 统计学 2022-07-01 Sai Li , Zijian Guo

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

统计方法学 · 统计学 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau

Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal…

统计方法学 · 统计学 2024-07-17 Wei Li , Rui Duan , Sai Li

Instrumental variables have been widely used to estimate the causal effect of a treatment on an outcome. Existing confidence intervals for causal effects based on instrumental variables assume that all of the putative instrumental variables…

统计方法学 · 统计学 2020-06-03 Hyunseung Kang , Youjin Lee , T. Tony Cai , Dylan S. Small

A common assumption in causal inference from observational data is that there is no hidden confounding. Yet it is, in general, impossible to verify this assumption from a single dataset. Under the assumption of independent causal mechanisms…

统计方法学 · 统计学 2023-11-07 Rickard K. A. Karlsson , Jesse H. Krijthe

Measuring conditional dependencies among the variables of a network is of great interest to many disciplines. This paper studies some shortcomings of the existing dependency measures in detecting direct causal influences or their lack of…

机器学习 · 统计学 2017-06-05 Jalal Etesami , Kun Zhang , Negar Kiyavash

Recently, interest has grown in the use of proxy variables of unobserved confounding for inferring the causal effect in the presence of unmeasured confounders from observational data. One difficulty inhibiting the practical use is finding…

机器学习 · 计算机科学 2024-05-28 Feng Xie , Zhengming Chen , Shanshan Luo , Wang Miao , Ruichu Cai , Zhi Geng

Causal mediation analysis is routinely conducted by applied researchers in a variety of disciplines. The goal of such an analysis is to investigate alternative causal mechanisms by examining the roles of intermediate variables that lie in…

统计方法学 · 统计学 2010-11-05 Kosuke Imai , Luke Keele , Teppei Yamamoto

Conditional independence of treatment assignment from potential outcomes is a commonly used but nonrefutable assumption. We derive identified sets for various treatment effect parameters under nonparametric deviations from this conditional…

统计方法学 · 统计学 2017-10-25 Matthew A. Masten , Alexandre Poirier

In the context of having an instrumental variable, the standard practice in causal inference begins by targeting an effect of interest and proceeds by formulating assumptions enabling its identification. We turn this around by adhering to…

统计理论 · 数学 2026-05-25 Carlos García Meixide , Mark J. van der Laan

Causal effect estimation has been studied by many researchers when only observational data is available. Sound and complete algorithms have been developed for pointwise estimation of identifiable causal queries. For non-identifiable causal…

机器学习 · 统计学 2023-06-26 Ziwei Jiang , Lai Wei , Murat Kocaoglu

To draw scientifically meaningful conclusions and build reliable models of quantitative phenomena, cause and effect must be taken into consideration (either implicitly or explicitly). This is particularly challenging when the measurements…

机器学习 · 计算机科学 2020-12-11 Max A. Little , Reham Badawy

When developing new interventions to minimize the harmful effects of an exposure, investigators usually target the mechanisms that mediate the causal effect of the exposure on the outcome. Predicting the causal effect of these new…

统计方法学 · 统计学 2021-08-10 Ian Shrier , Etsuji Suzuki

To evaluate a single cause of a binary effect, Dawid et al. (2014) defined the probability of causation, while Pearl (2015) defined the probabilities of necessity and sufficiency. For assessing the multiple correlated causes of a binary…

统计方法学 · 统计学 2024-04-09 Shanshan Luo , Yixuan Yu , Chunchen Liu , Feng Xie , Zhi Geng

Identifying causal relationships from observation data is difficult, in large part, due to the presence of hidden common causes. In some cases, where just the right patterns of conditional independence and dependence lie in the data---for…

人工智能 · 计算机科学 2018-01-08 David Heckerman

The procedure for establishing mediation, i.e., determining that an independent variable X affects a dependent variable Y through some mediator M, has been under debate. The classic causal steps require that a "total effect" be significant,…

计量经济学 · 经济学 2023-09-26 Tingxuan Han , Luxi Zhang , Xinshu Zhao , Ke Deng