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Various methods have emerged for conducting mediation analyses with multiple correlated mediators, each with distinct strengths and limitations. However, a comparative evaluation of these methods is lacking, providing the motivation for…

应用统计 · 统计学 2024-06-25 Mary Appah , D. Leann Long , George Howard , Melissa J. Smith

Estimating individual-level treatment effect from observational data is a fundamental problem in causal inference and has attracted increasing attention in the fields of education, healthcare, and public policy.In this work, we concentrate…

机器学习 · 计算机科学 2025-07-10 Hui Meng , Keping Yang , Xuyu Peng , Bo Zheng

This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

When it comes to clinical survival trials, regulatory restrictions usually require the application of methods that solely utilize baseline covariates and the intention-to-treat principle. Thereby a lot of potentially useful information is…

统计方法学 · 统计学 2015-04-27 Susanne Strohmaier , Kjetil Røysland , Rune Hoff , Ørnulf Borgan , Terje Pedersen , Odd O. Aalen

Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article we develop…

统计方法学 · 统计学 2023-04-26 Iván Díaz

We test against two different sets of data an apparently new approach to the analysis of the variance of a numerical variable which depends on qualitative characters. We suggest that this approach be used to complement other existing…

Causal mediation analysis decomposes the total effect of a treatment on an outcome into the indirect effect, operating through the mediator, and the direct effect, operating through other pathways. One can estimate only the pure indirect…

应用统计 · 统计学 2025-07-16 Vindyani Herath , Ronald J. Bosch , Judith J. Lok

Causal mediation analysis has been extended to estimate path-specific effects with multiple intermediate variables, isolating treatment effects through a mediator of interest while excluding pathways through its ancestors. Such analyses…

统计方法学 · 统计学 2026-05-12 Yang Bai , Sihan Wu , Baoluo Sun , Yifan Cui

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator…

统计方法学 · 统计学 2026-05-19 Yuki Ohnishi , Fan Li

Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors.…

Clinical decisions to treat and diagnose patients are affected by implicit biases formed by racism, ableism, sexism, and other stereotypes. These biases reflect broader systemic discrimination in healthcare and risk marginalizing already…

机器学习 · 计算机科学 2025-01-29 Kara Liu , Russ Altman , Vasilis Syrgkanis

Mediation analysis has become an important tool in the behavioral sciences for investigating the role of intermediate variables that lie in the path between a randomized treatment and an outcome variable. The influence of the intermediate…

Causal mediation analysis provides techniques for defining and estimating effects that may be endowed with mechanistic interpretations. With many scientific investigations seeking to address mechanistic questions, causal direct and indirect…

Researchers are often interested in treatment effects on outcomes that are only defined conditional on a post-treatment event status. For example, in a study of the effect of different cancer treatments on quality of life at end of…

Mediation analysis has traditionally focused on outcome-level summary contrasts, such as mean effects, which may obscure substantial distributional changes induced by complex and nonlinear causal mechanisms. We propose Distributional Causal…

机器学习 · 统计学 2026-05-05 Jinlun Zhang , Haoneng Huang , Zishu Zhan , Chunquan Ou

A mediation analysis approach is proposed for multiple exposures, multiple mediators, and a continuous scalar outcome under the linear structural equation modeling framework. It assumes that there exist orthogonal components that…

统计方法学 · 统计学 2022-09-12 Yi Zhao

Decomposing an exposure effect on an outcome into separate natural indirect effects through multiple mediators requires strict assumptions, such as correctly postulating the causal structure of the mediators, and no unmeasured confounding…

统计方法学 · 统计学 2021-02-04 Wen Wei Loh , Beatrijs Moerkerke , Tom Loeys , Stijn Vansteelandt

The presence of intermediate confounders, also called recanting witnesses, is a fundamental challenge to the investigation of causal mechanisms in mediation analysis, preventing the identification of natural path-specific effects. Proposed…

统计方法学 · 统计学 2024-01-10 Tat-Thang Vo , Nicholas Williams , Richard Liu , Kara E. Rudolph , Ivan Dıaz

We introduce a new nonparametric causal decomposition approach that identifies the mechanisms by which a treatment variable contributes to a group-based outcome disparity. Our approach distinguishes three mechanisms: group differences in 1)…

统计方法学 · 统计学 2024-12-17 Ang Yu , Felix Elwert

In this study, we introduce the application of causal disparity analysis to unveil intricate relationships and causal pathways between sensitive attributes and the targeted outcomes within real-world observational data. Our methodology…

计算机与社会 · 计算机科学 2024-08-08 Farnaz Kohankhaki , Shaina Raza , Oluwanifemi Bamgbose , Deval Pandya , Elham Dolatabadi