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Understanding how treatment effects vary on individual characteristics is critical in the contexts of personalized medicine, personalized advertising and policy design. When the characteristics are of practical interest are only a subset of…

统计方法学 · 统计学 2023-05-03 Peng Wu , ShaSha Han , Xingwei Tong , Runze Li

Applied researchers in biomedicine and related fields are often interested in estimating the causal effect of a treatment or intervention. Although randomized clinical trials are considered the gold standard for establishing causal effects,…

Objectives: To provide an overall quality assessment of the methods used for COVID-19-related studies using propensity score matching (PSM). Study Design and Setting: A systematic search was conducted in June 2021 on PubMed to identify…

其他定量生物学 · 定量生物学 2024-03-13 Chunhui Gu , Ruosha Li , Guoqiang Zhang

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish…

统计方法学 · 统计学 2024-03-26 Jingyue Huang , Changbao Wu , Leilei Zeng

Propensity score (PS) methods are widely used to estimate treatment effects in non-randomized studies. Variance is typically estimated using sandwich or bootstrap methods, which can either treat the PS as estimated or fixed. The latter is…

统计方法学 · 统计学 2025-11-17 Baoshan Zhang , Sean M. O'Brien , Yuan Wu , Laine E. Thomas

In this paper, we propose a robust method to estimate the average treatment effects in observational studies when the number of potential confounders is possibly much greater than the sample size. We first use a class of penalized…

统计方法学 · 统计学 2018-12-21 Yang Ning , Sida Peng , Kosuke Imai

Severe acute respiratory disease SARS-CoV-2 has had a found impact on public health systems and healthcare emergency response especially with respect to making decisions on the most effective measures to be taken at any given time. As…

机器学习 · 计算机科学 2023-09-19 Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

The spread of COVID-19 makes it essential to investigate its prevalence. In such investigation research, as far as we know, the widely-used sampling methods didn't use the information sufficiently about the numbers of the previously…

应用统计 · 统计学 2022-01-04 Ze Liu , Siyu Yi , Jianghu , Dong , Min-Qian Liu , Yongdao Zhou

Selective inference (post-selection inference) is a methodology that has attracted much attention in recent years in the fields of statistics and machine learning. Naive inference based on data that are also used for model selection tends…

统计方法学 · 统计学 2021-11-25 Yoshiyuki Ninomiya , Yuta Umezu , Ichiro Takeuchi

Propensity scores are commonly used to reduce the confounding bias in non-randomized observational studies for estimating the average treatment effect. An important assumption underlying this approach is that all confounders that are…

统计方法学 · 统计学 2022-08-02 Youfei Yu , Jiacong Du , Min Zhang , Zhenke Wu , Andrew M. Ryan , Bhramar Mukherjee

High-dimensional data can be useful for causal inference by providing many confounders that may bolster the plausibility of the ignorability assumption. Propensity score methods are powerful tools for causal inference, are popular in health…

统计方法学 · 统计学 2017-10-10 Jacob Spertus , Sharon-Lise Normand

Governments and public health authorities use seroprevalence studies to guide responses to the COVID-19 pandemic. Seroprevalence surveys estimate the proportion of individuals who have detectable SARS-CoV-2 antibodies. However, serologic…

应用统计 · 统计学 2022-11-11 Samuel P. Rosin , Bonnie E. Shook-Sa , Stephen R. Cole , Michael G. Hudgens

Continuous treatments have posed a significant challenge for causal inference, both in the formulation and identification of scientifically meaningful effects and in their robust estimation. Traditionally, focus has been placed on…

统计方法学 · 统计学 2022-06-29 Nima S. Hejazi , David Benkeser , Iván Díaz , Mark J. van der Laan

Two-phase sampling designs have been widely adopted in epidemiological studies to reduce costs when measuring certain biomarkers is prohibitively expensive. Under these designs, investigators commonly relate survival outcomes to risk…

统计方法学 · 统计学 2025-12-12 Jooho Kim , Yei Eun Shin

Covariate adjustment is an important tool in the analysis of randomized clinical trials and observational studies. It can be used to increase efficiency and thus power, and to reduce possible bias. While most statistical tests in randomized…

统计方法学 · 统计学 2011-08-03 Xiaoru Wu , Zhiliang Ying

One of the most common ways researchers compare survival outcomes across treatments when confounding is present is using Cox regression. This model is limited by its underlying assumption of proportional hazards; in some cases, substantial…

应用统计 · 统计学 2021-02-02 Elizabeth A. Handorf , Marc Smaldone , Sujana Movva , Nandita Mitra

Propensity score methods have become a part of the standard toolkit for applied researchers who wish to ascertain causal effects from observational data. While they were originally developed for binary treatments, several researchers have…

统计方法学 · 统计学 2013-09-26 Shandong Zhao , David A. van Dyk , Kosuke Imai

The pervasive use of prevalent cohort studies on disease duration, increasingly calls for appropriate methodologies to account for the biases that invariably accompany samples formed by such data. It is well-known, for example, that…

统计理论 · 数学 2013-11-07 Ashkan Ertefaie , Masoud Asgharian , David Stephens

In epidemiology and social sciences, propensity score methods are popular for estimating treatment effects using observational data, and multiple imputation is popular for handling covariate missingness. However, how to appropriately use…

统计方法学 · 统计学 2023-08-30 Trang Quynh Nguyen , Elizabeth A. Stuart

The propensity score is a common tool for estimating the causal effect of a binary treatment in observational data. In this setting, matching, subclassification, imputation, or inverse probability weighting on the propensity score can…

统计方法学 · 统计学 2018-01-03 Michael J Lopez , Roee Gutman
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