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Diffusion of molecules within biological cells and tissues is strongly influenced by crowding. A key quantity to characterize diffusion is the particle lifetime, which is the time taken for a diffusing particle to exit by hitting an…

生物物理 · 物理学 2018-04-03 Elliot J Carr , Matthew J Simpson

Calculating the mean exit time (MET) for models of diffusion is a classical problem in statistical physics, with various applications in biophysics, economics and heat and mass transfer. While many exact results for MET are known for…

生物物理 · 物理学 2022-03-04 Elliot J. Carr , Daniel J. VandenHeuvel , Joshua M. Wilson , Matthew J. Simpson

We study the transport properties of a system of active particles moving at constant speed in an heterogeneous two-dimensional space. The spatial heterogeneity is modeled by a random distribution of obstacles, which the active particles…

生物物理 · 物理学 2013-10-23 Oleksandr Chepizhko , Fernando Peruani

Many problems in physics, biology, and economics depend upon the duration of time required for a diffusing particle to cross a boundary. As such, calculations of the distribution of first passage time, and in particular the mean first…

We consider diffusion-controlled release of particles from $d$-dimensional radially-symmetric geometries. A quantity commonly used to characterise such diffusive processes is the proportion of particles remaining within the geometry over…

生物物理 · 物理学 2023-09-20 Luke P. Filippini , Matthew J. Simpson , Elliot J. Carr

This paper presents a simple tool for characterising the timescale for continuum diffusion processes through layered heterogeneous media. This mathematical problem is motivated by several practical applications such as heat transport in…

计算物理 · 物理学 2018-04-13 Elliot J. Carr

Describing particle transport at the macroscopic or mesoscopic level in non-ideal environments poses fundamental theoretical challenges in domains ranging from inter and intra-cellular transport in biology to diffusion in porous media. Yet,…

统计力学 · 物理学 2013-09-11 Marta Galanti , Duccio Fanelli , Francesco Piazza

We study photon diffusion in a two-dimensional random packing of monodisperse disks as a simple model of granular media and wet foams. We assume that the intensity reflectance of disks is a constant. We present an analytic expression for…

软凝聚态物质 · 物理学 2008-09-20 Zeinab Sadjadi , MirFaez Miri , M. Reza Shaebani , Sareh Nakhaee

The diffusion of molecules in complex intracellular environments can be strongly influenced by spatial heterogeneity and stochasticity. A key challenge when modelling such processes using stochastic random walk frameworks is that negative…

生物物理 · 物理学 2019-01-31 Elliot J. Carr , Matthew J. Simpson

The transport of particles in cells is influenced by the properties of intracellular networks they traverse while searching for localized target regions or reaction partners. Moreover, given the rapid turnover in many intracellular…

Diffusive transport of particles or, more generally, small objects is a ubiquitous feature of physical and chemical reaction systems. In configurations containing confining walls or constrictions transport is controlled both by the…

统计力学 · 物理学 2009-01-22 P. Sekhar Burada , Peter Hanggi , Fabio Marchesoni , Gerhard Schmid , Peter Talkner

Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into account the…

定量方法 · 定量生物学 2015-10-28 Paul R. Taylor , Christian A. Yates , Matthew J. Simpson , Ruth E. Baker

Turbulence in protoplanetary disks, when present, plays a critical role in transporting dust particles embedded in the gaseous disk component. When using a field description of dust dynamics, a diffusion approach is traditionally used to…

地球与行星天体物理 · 物理学 2023-08-15 Fabian Binkert

In this work, a two-dimensional time-fractional subdiffusion model is developed to investigate the underlying transport phenomena evolving in a binary medium comprised of two sub-domains occupied by homogeneous material. We utilise an…

数值分析 · 数学 2021-02-05 Libo Feng , Ian Turner , Patrick Perre , Kevin Burrage

When a fluid carrying a passive solute flows quickly through porous media, three key macroscale transport mechanisms occur. These mechanisms are diffusion, advection and dispersion, all of which depend on the microstructure of the porous…

流体动力学 · 物理学 2024-10-16 Lucy C Auton , Mohit P. Dalwadi , Ian M. Griffiths

By considering any one-dimensional time-homogeneous solvable diffusion process,this paper develops a complete analytical framework for computing the distribution of the last hitting time, to any level, and its joint distribution with the…

概率论 · 数学 2025-11-12 Giuseppe Campolieti , Yaode Sui

We consider a model of surface-mediated diffusion with alternating phases of pure bulk and surface diffusion. For this process, we compute the mean exit time from a disk through a hole on the circle. We develop a spectral approach to this…

数学物理 · 物理学 2014-04-24 O. Bénichou , D. S. Grebenkov , L. Hillairet , L. Phun , R. Voituriez , M. Zinsmeister

The surrounding world surprises us by the beauty and variety of complex shapes that emerge from nanometric to macroscopic scales. Natural or manufactured materials (sandstones, sedimentary rocks and cement), colloidal solutions (proteins…

数学物理 · 物理学 2009-09-10 Denis Grebenkov

Diffusion is the macroscopic manifestation of disordered molecular motion. Mathematically, diffusion equations are partial differential equations describing the fluid-like large-scale dynamics of parcels of molecules. Spatially…

流体动力学 · 物理学 2018-10-26 F. Sattin , A. Bonato , L. Salasnich

The migration of active particles in slowly moving, crowded, and heterogeneous media is fundamental to various biological processes and technological applications, such as cargo transport. In this study, we numerically investigate the…

软凝聚态物质 · 物理学 2024-12-04 Meng-Yuan Li , Ning Zheng , Yan-Wei Li
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