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The motility of eukaryotic cells is strongly influenced by their environment, with confined cells often developing qualitatively different motility patterns from those migrating on simple two-dimensional substrates. Recent experiments,…

细胞行为 · 定量生物学 2024-12-24 Pedrom Zadeh , Brian A. Camley

A toggle switch consists of two genes that mutually repress each other. This regulatory motif is active during cell differentiation and is thought to act as a memory device, being able to choose and maintain cell fate decisions. In this…

分子网络 · 定量生物学 2018-12-26 Michael K. Strasser , Fabian J. Theis , Carsten Marr

Adherent cells exert traction forces on to their environment, which allows them to migrate, to maintain tissue integrity, and to form complex multicellular structures. This traction can be measured in a perturbation-free manner with…

The microtubule cytoskeleton is responsible for sustained, long-range intracellular transport of mRNAs, proteins, and organelles in neurons. Neuronal microtubules must be stable enough to ensure reliable transport, but they also undergo…

动力系统 · 数学 2024-03-05 Anna C Nelson , Melissa M Rolls , Maria-Veronica Ciocanel , Scott A McKinley

The aim of this work is to quantify the spatio-temporal dynamics of flow-driven amoeboid locomotion in small ($\sim$100 $\mu$m) fragments of the true slime mold \phys {\it polycephalum}. In this model organism, cellular contraction drives…

细胞行为 · 定量生物学 2017-05-24 Shun Zhang , Robert D. Guy , Juan C. Lasheras , Juan C. del Alamo

Over the past few years, topological insulators have taken center stage in solid state physics. The desire to tune the topological invariants of the bulk and thus control the number of edge states has steered theorists and experimentalists…

介观与纳米尺度物理 · 物理学 2014-10-01 J. K. Asboth , B. Tarasinski , P. Delplace

Efficiently controlling the trapping process, especially the trapping efficiency, is central in the study of trap problem in complex systems, since it is a fundamental mechanism for diverse other dynamic processes. Thus, it is of…

统计力学 · 物理学 2013-07-12 Bin Wu , Zhongzhi Zhang

Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic…

生物物理 · 物理学 2017-04-12 Lishibanya Mohapatra , Bruce L. Goode , Jane Kondev

Aerial package transportation often requires complex spatial and temporal specifications to be satisfied in order to ensure safe and timely delivery from one point to another. It is usually efficient to transport versatile payloads using…

机器人学 · 计算机科学 2022-11-28 Nishanth Rao , Suresh Sundaram , Pushpak Jagtap

Biopolymer Networks play an important role in coordinating and regulating collective cellular dynamics via a number of signaling pathways. Here, we investigate the mechanical response of a model biopolymer network due to the active…

软凝聚态物质 · 物理学 2016-11-23 Long Liang , Christopher Jones , Bo Sun , Yang Jiao

Life and functioning of higher organisms depends on the continuous supply of metabolites to tissues and organs. What are the requirements on the transport network pervading a tissue to provide a uniform supply of nutrients, minerals, or…

生物物理 · 物理学 2018-07-09 Felix J. Meigel , Karen Alim

We analyse the behaviour of the linear phase of the Rayleigh-Taylor instability (RTI) in the presence of a foam. Such a problem may be relevant, for example, to some inertial confinement fusion (ICF) scenarios such as foams within the…

等离子体物理 · 物理学 2026-05-21 Antoine Bret , Audrey DeVault , Skylar Dannhoff , Maria Gatu Johnson , Chikang Li , Johan Frenje

A novel technique for the control of fine particle behavior is developed and demonstrated experimentally. The technique is called a time-averaged particle driving (TAPD) method. This method contains an application of positive pulses to two…

等离子体物理 · 物理学 2007-05-23 Satoru Iizuka , Kazuma Sakuta

Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems. In this work, we aim at linking cellular decisions taking place on a time scale…

细胞行为 · 定量生物学 2010-05-11 Steffen Waldherr , Jingbo Wu , Frank Allgöwer

Stall cells are spanwise-periodic flow structures that spontaneously form on airfoils operating near stall, fundamentally altering the aerodynamic loading distribution. Despite decades of experimental observations, a complete theoretical…

流体动力学 · 物理学 2026-02-11 Rishabh Mishra , Emmanuel Guilmineau , Ingrid Neunaber , Caroline Braud

Cell migration, which can be significantly affected by intracellular signaling pathways (ICSP) and extracellular matrix (ECM), plays a crucial role in many physiological and pathological processes. The efficiency of cell migration, which is…

生物物理 · 物理学 2021-07-07 Yanping Liu , Yang Jiao , Qihui Fan , Guoqiang Li , Jingru Yao , Gao Wang , Silong Lou , Guo Chen , Jianwei Shuai , Liyu Liu

Living creatures exhibit a remarkable diversity of locomotion mechanisms, evolving structures specialised for interacting with their environment. In the vast majority of cases, locomotor behaviours such as flying, crawling, and running, are…

生物物理 · 物理学 2020-07-28 Kirsty Y. Wan

Translation of mRNA into protein is a fundamental yet complex biological process with multiple factors that can potentially affect its efficiency. Here, we study a stochastic model describing the traffic flow of ribosomes along the mRNA…

数学物理 · 物理学 2020-01-23 Dan D. Erdmann-Pham , Khanh Dao Duc , Yun S. Song

We present analytical and numerical treatments for evaluating the time-of-flight momentum distribution for the stationary states of a two-boson system trapped in a quartic double-well potential, paying particular attention to the Tonks and…

原子物理 · 物理学 2009-08-18 Analabha Roy , Linda E. Reichl

Mammalian tissues contain networks and ordered arrays of collagen fibrils originating from the periodic self-assembly of helical 300 nm long tropocollagen complexes. The fibril radius is typically between 25 to 250 nm, and tropocollagen at…

生物物理 · 物理学 2014-09-16 Aidan I Brown , Laurent Kreplak , Andrew D Rutenberg