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High-speed atomic force microscopy (HS-AFM) is an indispensable technique in the biological field owing to its excellent imaging capability for the real-time observation of biomolecules with high spatial resolution. Furthermore, recent…

Atomic force microscopy (AFM) is one of the most promising methods for investigating the structure of materials at the micro and nanoscale levels, as well as their local physical-mechanical properties. The experimental data obtained with…

材料科学 · 物理学 2018-05-07 Oleg K. Garishin , Roman I. Izyumov , Alexander L. Svistkov

We report, for the first time, a multi-confocal Fluorescence Correlation Spectroscopy (mFCS) technique which allows parallel measurements at different locations, by combining a Spatial Light Modulator (SLM), with an Electron Multiplying-CCD…

Atomic Force Microscopy (AFM) combined with electrical modes provides a powerful contactless approach to characterize material electrical properties at the nanoscale. However, conventional electrostatic models often overlook dynamic charge…

介观与纳米尺度物理 · 物理学 2025-08-26 Mario Navarro-Rodriguez , Paul Philip Schmidt , Regina Hoffmann-Vogel , Andres M. Somoza , Elisa Palacios-Lidon

Atomic Force Microscopy (AFM) has a great potential as a tool to characterize mechanical and morphological properties of living cells; these properties have been shown to correlate with cells' fate and patho-physiological state in view of…

软凝聚态物质 · 物理学 2017-06-21 Luca Puricelli , Massimiliano Galluzzi , Carsten Schulte , Alessandro Podestà , Paolo Milani

Pseudo-heterodyne scattering-type scanning near-field optical microscopy (sSNOM) is applied in the mid-infrared region to detect the chemical composition of biomolecules on the nanoscale. However, the application of sSNOM in molecular…

仪器与探测器 · 物理学 2025-08-06 Yusuke Sakiyama , Emanuel Pfitzner , Santiago H. Andany , Georg E. Fantner , Joachim Heberle

Correlative nanoscale surface characterization benefits from simultaneously measuring electronic and structural properties in the same environment, a capability that is essential for modern-day materials science and semiconductor failure…

介观与纳米尺度物理 · 物理学 2026-05-18 Prabhu Prasad Swain , Nahid Hosseini , Eveline. S Mayner , Aleksandra Radenovic , Marcos Penedo , Georg E. Fantner

We present the design and experimental results of a near-field scanning microwave microscope (NSMM) working at a frequency of 1GHz. Our microscope is unique in that the sensing probe is separated from the excitation electrode to…

材料科学 · 物理学 2009-11-13 K. Lai , M. B. Ji , N. Leindecker , M. A. Kelly , Z. X. Shen

We demonstrate volumetric fluorescence lifetime microscopy (FLIM) using the electro-optic FLIM technique. Images acquired in a selective plane illumination microscope are gated using a Pockels cell driven at 80 MHz, enabling light sheet…

Scattering scanning near-field optical microscopy (s-SNOM) is a promising technique for overcoming Abbe diffraction limit and substantially enhancing the spatial resolution in spectroscopic imaging. The s-SNOM works by exposing an atomic…

量子物理 · 物理学 2024-03-22 Soheil Khajavi , Zahra Shaterzadeh-Yazdi , Ali Eghrari , Mohammad Neshat

As mechanical devices in the nano/micro length scale are increasingly employed, it is crucial to understand nanoscale friction and wear especially at technically relevant sliding velocities. Accordingly, a novel technique has been developed…

Highly ordered periodic arrays of silver nanoparticles have been fabricated which exhibit surface plasmon resonances in the visible spectrum. We demonstrate the ability of these structures to alter the fluorescence properties of vicinal dye…

其他凝聚态物理 · 物理学 2009-11-13 T. Ritman-Meer , N. I. Cade , D. Richards

Fluorescence Lifetime Imaging Microscopy in the time domain is typically performed by recording the arrival time of photons either by using electronic time tagging or a gated detector. As such the temporal resolution is limited by the…

Anomaly detection is crucial in industrial product quality inspection. Failing to detect tiny defects often leads to serious consequences. Existing methods face a structure-semantics trade-off: structure-oriented models (such as…

计算机视觉与模式识别 · 计算机科学 2026-01-05 Naiqi Zhang , Chuancheng Shi , Jingtong Dou , Wenhua Wu , Fei Shen , Jianhua Cao

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

光学 · 物理学 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

We study the velocity dependence of the frictional force of the tip of an atomic force microscope as it is dragged across a surface, taking into account memory effects and thermal fluctuations. Memory effects are described by a coupling of…

介观与纳米尺度物理 · 物理学 2010-08-31 Enzo Granato , S. C. Ying

Coherent nonlinear optical micro-spectroscopy is a frequently used tool in modern material science, as it is sensitive to many different local observables, which comprise, among others, crystal symmetry and vibrational properties. The…

光学 · 物理学 2023-04-12 Kai J. Spychala , Zeeshan H. Amber , Lukas M. Eng , Michael Rüsing

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…

It has been shown that electron transitions, as measured in a scanning tunnelling microscope (STM), are related to chemical interactions in a tunnelling barrier. Here, we show that the shape and apparent height of subatomic features in an…

材料科学 · 物理学 2009-11-11 Linda Zotti , Werner A. Hofer , Franz J. Giessibl

We present a detailed investigation of the near-field optical response of core-shell nanoparticles using Fourier-demodulated full-wave simulations, revealing significant modifications to established contrast mechanisms in scattering-type…