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In various biomedical studies, analysis often focuses on data magnitudes, particularly when algebraic signs are irrelevant or lost. For repeated measures studies involving magnitude outcomes, incorporating random effects is essential as…

统计方法学 · 统计学 2025-07-16 Wen Teng , Niall D. Ferguson , Ewan C. Goligher , Anna Heath

We introduce a numerically tractable formulation of Bayesian joint models for longitudinal and survival data. The longitudinal process is modelled using generalised linear mixed models, while the survival process is modelled using a…

统计方法学 · 统计学 2021-04-23 Danilo Alvares , Francisco Javier Rubio

In many clinical and epidemiological studies, collecting longitudinal measurements together with time-to-event outcomes is essential. Accurately estimating the association between longitudinal markers and event risks, as well as identifying…

Motivated by recent findings that within-subject (WS) visit-to-visit variabilities of longitudinal biomarkers can be strong risk factors for health outcomes, this paper introduces and examines a new joint model of a longitudinal biomarker…

统计方法学 · 统计学 2023-05-08 Shanpeng Li , Daniel S. Nuyujukian , Robyn L. McClelland , Peter D. Reaven , Jin Zhou , Hua Zhou , Gang Li

Joint multivariate longitudinal and time-to-event data are gaining increasing attention in the biomedical sciences where subjects are followed over time to monitor the progress of a disease or medical condition. In the insurance context,…

统计方法学 · 统计学 2019-02-12 Edward W. Frees , Catalina Bolancé , Montserrat Guillen , Emiliano Valdez

A time-varying bivariate copula joint model, which models the repeatedly measured longitudinal outcome at each time point and the survival data jointly by both the random effects and time-varying bivariate copulas, is proposed in this…

统计方法学 · 统计学 2024-12-03 Zili Zhang , Christiana Charalambous , Peter Foster

In applications such as biomedical studies, epidemiology, and social sciences, recurrent events often co-occur with longitudinal measurements and a terminal event, such as death. Therefore, jointly modeling longitudinal measurements,…

机器学习 · 统计学 2024-04-08 Zhiyue Zhang , Yao Zhao , Yanxun Xu

In biomedical studies, longitudinal processes are collected till time-to-event, sometimes on nested timescales (example, days within months). Most of the literature in joint modeling of longitudinal and time-to-event data has focused on…

统计方法学 · 统计学 2023-07-19 Abhisek Saha , Ling Ma , Animikh Biswas , Rajeshwari Sundaram

Joint modelling of longitudinal observations and event times continues to remain a topic of considerable interest in biomedical research. For example, in HIV studies, the longitudinal bio-marker such as CD4 cell count in a patient's blood…

统计方法学 · 统计学 2024-07-19 Srimanti Dutta , Arindom Chakraborty , Dipankar Bandyopadhyay

Missing data occur in many types of studies and typically complicate the analysis. Multiple imputation, either using joint modelling or the more flexible fully conditional specification approach, are popular and work well in standard…

统计方法学 · 统计学 2020-09-02 Nicole S. Erler , Dimitris Rizopoulos , Emmanuel M. E. H. Lesaffre

In biomedical studies it is common to collect data on multiple biomarkers during study follow-up for dynamic prediction of a time-to-event clinical outcome. The biomarkers are typically intermittently measured, missing at some event times,…

统计方法学 · 统计学 2021-07-05 Ning Li , Yi Liu , Shanpeng Li , Robert M. Elashoff , Gang Li

Joint modelling of longitudinal and time-to-event data has received much attention recently. Increasingly, extensions to standard joint modelling approaches are being proposed to handle complex data structures commonly encountered in…

This paper takes a quick look at Bayesian joint models (BJM) for longitudinal and survival data. A general formulation for BJM is examined in terms of the sampling distribution of the longitudinal and survival processes, the conditional…

统计方法学 · 统计学 2020-05-27 Carmen Armero

The availability of mobile health (mHealth) technology has enabled increased collection of intensive longitudinal data (ILD). ILD have potential to capture rapid fluctuations in outcomes that may be associated with changes in the risk of an…

This chapter provides an introduction to the analysis of relational event data (i.e., actions, interactions, or other events involving multiple actors that occur over time) within the R/statnet platform. We begin by reviewing the basics of…

统计方法学 · 统计学 2017-08-01 Carter T. Butts , Christopher Steven Marcum

Longitudinal biomarker data and health outcomes are routinely collected in many studies to assess how biomarker trajectories predict health outcomes. Existing methods primarily focus on mean biomarker profiles, treating variability as a…

Joint modelling of longitudinal and time-to-event data is usually described by a joint model which uses shared or correlated latent effects to capture associations between the two processes. Under this framework, the joint distribution of…

统计方法学 · 统计学 2022-03-07 Zili Zhang , Christiana Charalambous , Peter Foster

We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables. Our joint model…

统计方法学 · 统计学 2014-04-07 Alessio Farcomeni , Sara Viviani

Joint models (JM) for longitudinal and survival data have gained increasing interest and found applications in a wide range of clinical and biomedical settings. These models facilitate the understanding of the relationship between outcomes…

统计方法学 · 统计学 2023-08-25 Sida Chen , Danilo Alvares , Christopher Jackson , Jessica Barrett

Missing data and noisy observations pose significant challenges for reliably predicting events from irregularly sampled multivariate time series (longitudinal) data. Imputation methods, which are typically used for completing the data prior…

机器学习 · 统计学 2017-08-17 Hossein Soleimani , James Hensman , Suchi Saria