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We propose two novel approaches to the recovery of an (approximately) sparse signal from noisy linear measurements in the case that the signal is a priori known to be non-negative and obey given linear equality constraints, such as simplex…

信息论 · 计算机科学 2015-06-17 Jeremy Vila , Philip Schniter

The single-cell RNA sequencing (scRNA-seq) technology enables researchers to study complex biological systems and diseases with high resolution. The central challenge is synthesizing enough scRNA-seq samples; insufficient samples can impede…

基因组学 · 定量生物学 2023-12-25 Yixuan Wang , Shuangyin Li , Shimin DI , Lei Chen

Phase retrieval (PR) is a popular research topic in signal processing and machine learning. However, its performance degrades significantly when the measurements are corrupted by noise or outliers. To address this limitation, we propose a…

最优化与控制 · 数学 2025-05-30 Jun Fan , Ailing Yan , Xianchao Xiu , Wanquan Liu

To strike a balance between energy efficiency and data quality control, this paper proposes a sensor censoring scheme for distributed sparse signal recovery via compressive-sensing based wireless sensor networks. In the proposed approach,…

信息论 · 计算机科学 2018-01-16 Jwo-Yuh Wu , Ming-Hsun Yang , Tsang-Yi Wang

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of cellular heterogeneity, enabling detailed molecular profiling at the individual cell level. However, integrating high-dimensional single-cell data into causal mediation…

统计方法学 · 统计学 2025-10-01 Seungjun Ahn , Li Chen , Maaike van Gerwen , Panos Roussos , Zhigang Li

Ultra high-throughput sequencing of transcriptomes (RNA-Seq) is a widely used method for quantifying gene expression levels due to its low cost, high accuracy and wide dynamic range for detection. However, the nature of RNA-Seq makes it…

统计方法学 · 统计学 2016-08-30 Hui Jiang , Tianyu Zhan

Negative sampling is highly effective in handling missing annotations for named entity recognition (NER). One of our contributions is an analysis on how it makes sense through introducing two insightful concepts: missampling and…

计算与语言 · 计算机科学 2022-02-28 Yangming Li , Lemao Liu , Shuming Shi

Single-cell RNA sequencing allows the quantification of gene expression at the individual cell level, enabling the study of cellular heterogeneity and gene expression dynamics. Dimensionality reduction is a common preprocessing step…

统计计算 · 统计学 2025-10-14 Cristian Castiglione , Alexandre Segers , Lieven Clement , Davide Risso

Large Language Models (LLMs) have demonstrated improved generation performance by incorporating externally retrieved knowledge, a process known as retrieval-augmented generation (RAG). Despite the potential of this approach, existing…

计算与语言 · 计算机科学 2025-11-24 Lu Dai , Yijie Xu , Jinhui Ye , Hao Liu , Hui Xiong

Recent advances in high-resolution sequencing have paved the way for population-scale analysis in single-cell RNA-sequencing (scRNA-seq) data. scRNA-seq data, in particular, have proven to be extremely powerful in profiling a variety of…

统计方法学 · 统计学 2025-10-30 Hanxuan Ye , Zachary Qian , Hongzhe Li

Motivation: The mapping of RNA-seq reads to their transcripts of origin is a fundamental task in transcript expression estimation and differential expression scoring. Where ambiguities in mapping exist due to transcripts sharing sequence,…

基因组学 · 定量生物学 2015-01-28 James Hensman , Peter Glaus , Antti Honkela , Magnus Rattray

Recent advances in single-cell technologies have advanced our understanding of gene regulation and cellular heterogeneity at single-cell resolution. Single-cell data contain both gene expression levels and the proportion of expressing…

统计方法学 · 统计学 2026-04-10 Seungjun Ahn , Donald Porchia , Panos Roussos , Maaike van Gerwen , Qing Lu , Zhigang Li

Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST ``digital northern'', are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these…

定量方法 · 定量生物学 2013-10-29 Ricardo ZN Vêncio , Leonardo Varuzza , Carlos AB Pereira , Helena Brentani , Ilya Shmulevich

Motivation: Bulk RNA-Seq is a widely used method for studying gene expression across a variety of contexts. The significance of RNA-Seq studies has grown with the advent of high-throughput sequencing technologies. Computational methods have…

基因组学 · 定量生物学 2025-03-28 Juliana Costa-Silva , David Menotti , Fabricio M. Lopes

RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at…

应用统计 · 统计学 2015-12-11 David Rossell , Camille Stephan-Otto Attolini , Manuel Kroiss , Almond Stöcker

We propose to reduce the original well-posed problem of compressive sensing to weighted-MAX-SAT. Compressive sensing is a novel randomized data acquisition approach that linearly samples sparse or compressible signals at a rate much below…

信息论 · 计算机科学 2019-05-28 Ramin Ayanzadeh , Milton Halem , Tim Finin

It is now well understood that (1) it is possible to reconstruct sparse signals exactly from what appear to be highly incomplete sets of linear measurements and (2) that this can be done by constrained L1 minimization. In this paper, we…

统计方法学 · 统计学 2007-11-13 Emmanuel J. Candes , Michael B. Wakin , Stephen P. Boyd

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

机器学习 · 计算机科学 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

Because of the ambiguous and subjective property of the facial expression recognition (FER) task, the label noise is widely existing in the FER dataset. For this problem, in the training phase, current FER methods often directly predict…

计算机视觉与模式识别 · 计算机科学 2023-05-30 Xiang Zhang , Yan Lu , Huan Yan , Jingyang Huang , Yusheng Ji , Yu Gu

Sequential models achieve state-of-the-art results in audio, visual and textual domains with respect to both estimating the data distribution and generating high-quality samples. Efficient sampling for this class of models has however…