相关论文: Brain Energetics, Mitochondria, and Traumatic Brai…
This paper addresses the question of the brain's critical dynamics after an injury such as a stroke. It is hypothesized that the healthy brain operates near a phase transition (critical point), which provides optimal conditions for…
The complexity of neural dynamics stems in part from the complexity of the underlying anatomy. Yet how the organization of white matter architecture constrains how the brain transitions from one cognitive state to another remains unknown.…
Research in blast-induced lung injury resulted in exposure thresholds that are useful in understanding and protecting humans from such injury. Because traumatic brain injury (TBI) due to blast exposure has become a prominent medical and…
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive…
Flexible reconfiguration of human brain networks supports cognitive flexibility and learning. However, modulating flexibility to enhance learning requires an understanding of the relationship between flexibility and brain state. In an…
A critical mystery in neuroscience lies in determining how anatomical structure impacts the complex functional dynamics of human thought. How does large-scale brain circuitry constrain states of neuronal activity and transitions between…
Does the energy requirements for the human brain give energy constraints that give reason to doubt the feasibility of artificial intelligence? This report will review some relevant estimates of brain bioenergetics and analyze some of the…
The free energy principle has been proposed as a unifying account of brain function. It is closely related, and in some cases subsumes, earlier unifying ideas such as Bayesian inference, predictive coding, and active learning. This article…
Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…
Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…
The generation of spikes by neurons is energetically a costly process and the evaluation of the metabolic energy required to maintain the signalling activity of neurons a challenge of practical interest. Neuron models are frequently used to…
To meet ongoing cognitive demands, the human brain must seamlessly transition from one brain state to another, in the process drawing on different cognitive systems. How does the brain's network of anatomical connections help facilitate…
The analysis of brain connectivity aims to understand the emergence of functional networks into the brain. This information can be used in the process of electroencephalographic (EEG) signal analysis and classification for a braincomputer…
A nonlinear dynamical modeling of interaction between automatic and conscious processes in the brain is described. Effects of sensations, emotions and reflections on the electromagnetic activity of the brain are represented in terms of…
The fundamental, powerful process of computation in the brain has been widely misunderstood. The paper [1] associates the general failure to build intelligent thinking machines with current reductionist principles of temporal coding and…
Electrical brain stimulation is currently being investigated as a therapy for neurological disease. However, opportunities to optimize such therapies are challenged by the fact that the beneficial impact of focal stimulation on both…
Today, the human brain can be studied as a whole. Electroencephalography, magnetoencephalography, or functional magnetic resonance imaging techniques provide functional connectivity patterns between different brain areas, and during…
Trans-membrane gradients and fluxes of cations (H+, Na+, K+, etc.) were deemed to be the rationale of electrical activities of aerobic cells/organelles, as per classical perceptions. Murburn concept (an umbrella of theorization based in…
Dendritic spines, the carriers of long-term memory, occupy a small fraction of cortical space, and yet they are the major consumers of brain metabolic energy. What fraction of this energy goes for synaptic plasticity, correlated with…
Stroke is one of the main causes of human disabilities. Experimental observations indicate that several mechanisms are activated during the recovery of functional activity after a stroke. Here we unveil how the brain recovers by explaining…