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We propose sufficient conditions and computationally efficient procedures for false discovery rate control in multiple testing when the $p$-values are related by a known \emph{dependency graph} -- meaning that we assume independence of…

统计方法学 · 统计学 2025-07-01 Drew T. Nguyen , William Fithian

This work concerns controlling the false discovery rate (FDR) in networks under communication constraints. We present sample-and-forward, a flexible and communication-efficient version of the Benjamini-Hochberg (BH) procedure for multihop…

信号处理 · 电气工程与系统科学 2023-05-17 Mehrdad Pournaderi , Yu Xiang

Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW-CRTs must account for time trends in the outcome…

统计方法学 · 统计学 2024-07-16 Lee Kennedy-Shaffer , Victor De Gruttola , Marc Lipsitch

Testing for differences in features between clusters in various applications often leads to inflated false positives when practitioners use the same dataset to identify clusters and then test features, an issue commonly known as ``double…

统计方法学 · 统计学 2024-10-10 Lijun Wang , Yingxin Lin , Hongyu Zhao

This research deals with massive multiple hypothesis testing. First regarding multiple tests as an estimation problem under a proper population model, an error measurement called Erroneous Rejection Ratio (ERR) is introduced and related to…

统计理论 · 数学 2007-06-13 Cheng Cheng

Establishing the frequentist properties of Bayesian approaches widens their appeal and offers new understanding. In hypothesis testing, Bayesian model averaging addresses the problem that conclusions are sensitive to variable selection. But…

统计方法学 · 统计学 2025-05-12 Helen R. Fryer , Nicolas Arning , Daniel J. Wilson

We introduce an Integrative Ranking and Thresholding (IRT) framework for fusing evidence from multiple testing procedures. The key innovation is a method that transforms binary testing decisions into compound $e-$values, enabling the…

统计方法学 · 统计学 2025-09-04 Trambak Banerjee , Bowen Gang , Jianliang He

Multiple testing problems arising in modern scientific applications can involve simultaneously testing thousands or even millions of hypotheses, with relatively few true signals. In this paper, we consider the multiple testing problem where…

统计方法学 · 统计学 2016-06-28 Ang Li , Rina Foygel Barber

The problem of large-scale spatial multiple testing is often encountered in various scientific research fields, where the signals are usually enriched on some regions while sparse on others. To integrate spatial structure information from…

统计方法学 · 统计学 2023-09-28 Pengfei Wang , Pengyu Yan , Canhui Li

Genome-wide association analysis has generated much discussion about how to preserve power to detect signals despite the detrimental effect of multiple testing on power. We develop a weighted multiple testing procedure that facilitates the…

统计理论 · 数学 2007-06-13 Kathryn Roeder , Bernie Devlin , Larry Wasserman

Multiple testing adjustments, such as the Benjamini and Hochberg (1995) step-up procedure for controlling the false discovery rate (FDR), are typically applied to families of tests that control significance level in the classical sense: for…

统计方法学 · 统计学 2025-05-19 Timothy B. Armstrong

Given a nonparametric Hidden Markov Model (HMM) with two states, the question of constructing efficient multiple testing procedures is considered, treating one of the states as an unknown null hypothesis. A procedure is introduced, based on…

统计理论 · 数学 2021-01-12 Kweku Abraham , Ismael Castillo , Elisabeth Gassiat

Matrix-variate Gaussian graphical models (GGM) have been widely used for modeling matrix-variate data. Since the support of sparse precision matrix represents the conditional independence graph among matrix entries, conducting support…

统计方法学 · 统计学 2017-09-01 Xi Chen , Weidong Liu

This article considers the problem of multiple hypothesis testing using $t$-tests. The observed data are assumed to be independently generated conditional on an underlying and unknown two-state hidden model. We propose an asymptotically…

统计理论 · 数学 2011-02-22 Hongyuan Cao , Michael R. Kosorok

The present paper introduces new adaptive multiple tests which rely on the estimation of the number of true null hypotheses and which control the false discovery rate (FDR) at level alpha for finite sample size. We derive exact formulas for…

统计理论 · 数学 2014-10-24 Philipp Heesen , Arnold Janssen

We introduce a multiple testing procedure (TreeBH) which addresses the challenge of controlling error rates at multiple levels of resolution. Conceptually, we frame this problem as the selection of hypotheses which are organized…

统计方法学 · 统计学 2018-10-25 Marina Bogomolov , Christine B. Peterson , Yoav Benjamini , Chiara Sabatti

The clustering task consists in partitioning elements of a sample into homogeneous groups. Most datasets contain individuals that are ambiguous and intrinsically difficult to attribute to one or another cluster. However, in practical…

统计理论 · 数学 2023-10-26 Ariane Marandon , Tabea Rebafka , Etienne Roquain , Nataliya Sokolovska

When conducting large scale inference, such as genome-wide association studies or image analysis, nominal $p$-values are often adjusted to improve control over the family-wise error rate (FWER). When the majority of tests are null,…

统计方法学 · 统计学 2017-07-20 Sarah Fletcher Mercaldo , Jeffrey D. Blume

Benjamini and Hochberg (1995) proposed the false discovery rate (FDR) as an alternative to the family-wise error rate in multiple testing problems, and proposed a procedure to control the FDR. For discrete data this procedure may be highly…

统计方法学 · 统计学 2014-01-28 Ruth Heller , Hadas Gur

The simultaneous analysis of many statistical tests is ubiquitous in applications. Perhaps the most popular error rate used for avoiding type one error inflation is the false discovery rate (FDR). However, most theoretical and software…

统计计算 · 统计学 2019-04-04 Guillermo Durand , Florian Junge , Sebastian Döhler , Etienne Roquain