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Early detection of Alzheimer disease is crucial for deploying interventions and slowing the disease progression. A lot of machine learning and deep learning algorithms have been explored in the past decade with the aim of building an…

图像与视频处理 · 电气工程与系统科学 2022-09-26 Narotam Singh , Patteshwari. D , Neha Soni , Amita Kapoor

Alzheimer's disease is a progressive neurodegenerative disorder that remains challenging to predict due to its multifactorial etiology and the complexity of multimodal clinical data. Accurate forecasting of clinically relevant biomarkers,…

机器学习 · 计算机科学 2026-02-03 Yilang Ding , Jiawen Ren , Jiaying Lu , Gloria Hyunjung Kwak , Armin Iraji , Shengpu Tang , Alex Fedorov

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

机器学习 · 计算机科学 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

Early and accurate detection of Alzheimer's disease (AD) remains a major challenge in medical diagnosis due to its subtle onset and progressive nature. This research introduces an explainable ensemble learning Framework designed to classify…

机器学习 · 计算机科学 2026-03-06 Nishan Mitra

Alzheimer's disease is an untreatable, progressive brain disorder that slowly robs people of their memory, thinking abilities, and ultimately their capacity to complete even the most basic tasks. Among older adults, it is the most frequent…

图像与视频处理 · 电气工程与系统科学 2025-02-11 Nasser A Alsadhan

Alzheimer's disease is the most common neurodegenerative disease. The aim of this study is to infer structural changes in brain connectivity resulting from disease progression using cortical thickness measurements from a cohort of…

Alzheimer's Disease (AD) is a progressive neurodegenerative condition that adversely affects cognitive abilities. Language-related changes can be automatically identified through the analysis of outputs from linguistic assessment tasks,…

Alzheimer's disease is a debilitating disorder marked by a decline in cognitive function. Timely identification of the disease is essential for the development of personalized treatment strategies that aim to mitigate its progression. The…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Xin Hong , Kaifeng Huang

Confirming Alzheimer's disease (AD) typically relies on positron emission tomography (PET), which remains costly and invasive, motivating the use of structural MRI-based prescreening. Deep learning on non-Euclidean manifolds, particularly…

计算机视觉与模式识别 · 计算机科学 2026-05-27 Geonwoo Baek , Ikbeom Jang

We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their…

统计方法学 · 统计学 2024-04-15 Eardi Lila , Wenbo Zhang , Swati Rane Levendovszky

Alzheimer's disease (AD) is a major neurodegenerative condition that affects millions around the world. As one of the main biomarkers in the AD diagnosis procedure, brain amyloid positivity is typically identified by positron emission…

图像与视频处理 · 电气工程与系统科学 2026-03-10 Yanxi Chen , Mohammad Farazi , Zhangsihao Yang , Yonghui Fan , Nicholas Ashton , Eric M Reiman , Yi Su , Yalin Wang

Alzheimer's disease is one of the diseases that mostly affects older people without being a part of aging. The most common symptoms include problems with communicating and abstract thinking, as well as disorientation. It is important to…

图像与视频处理 · 电气工程与系统科学 2020-12-01 Fatih Altay , Guillermo Ramon Sanchez , Yanli James , Stephen V. Faraone , Senem Velipasalar , Asif Salekin

Estimating brain age (BA) from T1-weighted magnetic resonance images (MRIs) provides a powerful framework for quantifying anatomical brain aging. Whereas global BA (GBA) summarizes overall brain health, local BA (LBA) provides cortically…

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a common brain disorder that causes memory loss…

图像与视频处理 · 电气工程与系统科学 2024-03-11 Maleka Khatun , Md Manowarul Islam , Habibur Rahman Rifat , Md. Shamim Bin Shahid , Md. Alamin Talukder , Md Ashraf Uddin

Alzheimer's disease is characterised by the spreading of misfolded proteins and progressive structural changes in the brain. Despite significant clinical research, understanding how microscopic protein dynamics translate into macroscopic…

计算工程、金融与科学 · 计算机科学 2026-03-23 A. Vazquez-Palomo , C. Betegón , J. Weickenmeier , E. Martínez-Pañeda

Deep Learning (DL) in neuroimaging has become increasingly relevant for detecting neurological conditions and neurodegenerative disorders. One of the most predominant biomarkers in neuroimaging is represented by brain age, which has been…

图像与视频处理 · 电气工程与系统科学 2025-11-20 Carlo Alberto Barbano , Matteo Brunello , Benoit Dufumier , Marco Grangetto

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics.…

图像与视频处理 · 电气工程与系统科学 2025-05-21 Soyabul Islam Lincoln , Mirza Mohd Shahriar Maswood

Alzheimer's disease is a neurodegenerative condition that accelerates cognitive decline relative to normal aging. It is of critical scientific importance to gain a better understanding of early disease mechanisms in the brain to facilitate…

应用统计 · 统计学 2022-01-19 D. Andrew Brown , Christopher S. McMahan , Russell T. Shinohara , Kristin A. Linn

We propose a topological framework to study the evolution of Alzheimer's disease, the most common neurodegenerative disease. The modeling of this disease starts with the representation of the brain connectivity as a graph and the seeding of…

神经元与认知 · 定量生物学 2023-09-20 Christian Goodbrake , David Beers , Travis B. Thompson , Heather A. Harrington , Alain Goriely

Alzheimers disease is a deadly neurological condition, impairing important memory and brain functions. Alzheimers disease promotes brain shrinkage, ultimately leading to dementia. Dementia diagnosis typically takes 2.8 to 4.4 years after…