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Causal inference is a science with multi-disciplinary evolution and applications. On the one hand, it measures effects of treatments in observational data based on experimental designs and rigorous statistical inference to draw causal…

统计方法学 · 统计学 2022-09-05 Jingying Zeng , Run Wang

Matching and weighting methods for observational studies involve the choice of an estimand, the causal effect with reference to a specific target population. Commonly used estimands include the average treatment effect in the treated (ATT),…

统计方法学 · 统计学 2023-07-12 Noah Greifer , Elizabeth A. Stuart

There is intense interest in applying machine learning to problems of causal inference in fields such as healthcare, economics and education. In particular, individual-level causal inference has important applications such as precision…

机器学习 · 统计学 2017-05-17 Uri Shalit , Fredrik D. Johansson , David Sontag

Intervention intuition is often used in model explanation where the intervention effect of a feature on the outcome is quantified by the difference of a model prediction when the feature value is changed from the current value to the…

机器学习 · 计算机科学 2024-10-22 Debo Cheng , Ziqi Xu , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Le , Jixue Liu

In this paper we study approaches for dealing with treatment when developing a clinical prediction model. Analogous to the estimand framework recently proposed by the European Medicines Agency for clinical trials, we propose a…

We study causal effect estimation from a mixture of observational and interventional data in a confounded linear regression model with multivariate treatments. We show that the statistical efficiency in terms of expected squared error can…

统计方法学 · 统计学 2023-07-03 Klaus-Rudolf Kladny , Julius von Kügelgen , Bernhard Schölkopf , Michael Muehlebach

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

机器学习 · 计算机科学 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

Discovery of causal relations from observational data is essential for many disciplines of science and real-world applications. However, unlike other machine learning algorithms, whose development has been greatly fostered by a large amount…

机器学习 · 计算机科学 2019-10-29 Ruibo Tu , Kun Zhang , Bo Christer Bertilson , Hedvig Kjellström , Cheng Zhang

We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE).…

A fundamental challenge in causal inference with observational data is correct specification of a causal model. When there is model uncertainty, analysts may seek to use estimates from multiple candidate models that rely on distinct, and…

统计方法学 · 统计学 2026-03-03 Rohit Bhattacharya , Ina Ocelli , Ted Westling

Causal mediation analysis examines causal pathways linking exposures to disease. The estimation of interventional effects, which are mediation estimands that overcome certain identifiability problems of natural effects, has been advanced…

统计方法学 · 统计学 2025-04-23 Tong Chen , Stijn Vansteelandt , David Burgner , Toby Mansell , Margarita Moreno-Betancur

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

The standard approach to causal modelling especially in social and health sciences is the potential outcomes framework due to Neyman and Rubin. In this framework, observations are thought to be drawn from a distribution over variables of…

统计方法学 · 统计学 2025-07-18 Benedikt Höltgen , Robert C. Williamson

Intercurrent events (ICEs) and missing values are inevitable in clinical trials of any size and duration, making it difficult to assess the treatment effect for all patients in randomized clinical trials. Defining the appropriate estimand…

应用统计 · 统计学 2020-06-01 Yongming Qu , Junxiang Luo , Stephen J. Ruberg

Causal inference is the goal of randomized trials and many observational studies. The first step in a formal causal inference framework is to define the causal estimand, and in both types of study this can be intuitively defined as the…

统计方法学 · 统计学 2025-09-09 Margarita Moreno-Betancur , Rushani Wijesuriya , John B. Carlin

We introduce computational causal inference as an interdisciplinary field across causal inference, algorithms design and numerical computing. The field aims to develop software specializing in causal inference that can analyze massive…

统计计算 · 统计学 2020-07-22 Jeffrey C. Wong

The causal effect of an intervention (treatment/exposure) on an outcome can be estimated by: i) specifying knowledge about the data-generating process; ii) assessing under what assumptions a target quantity, such as for example a causal…

统计方法学 · 统计学 2021-03-05 Michael Schomaker

Causal inference plays an important role in explanatory analysis and decision making across various fields like statistics, marketing, health care, and education. Its main task is to estimate treatment effects and make intervention…

统计方法学 · 统计学 2024-07-22 Yingrong Wang , Haoxuan Li , Minqin Zhu , Anpeng Wu , Ruoxuan Xiong , Fei Wu , Kun Kuang

The aim of this paper is to discuss a recent result which shows that probabilistic inference in the presence of (unknown) causal mechanisms can be tractable for models that have traditionally been viewed as intractable. This result was…

人工智能 · 计算机科学 2022-02-08 Adnan Darwiche

Though the topic of causal inference is typically considered in the context of classical statistical models, recent years have seen great interest in extending causal inference techniques to quantum and generalized theories. Causal…

计算机科学中的逻辑 · 计算机科学 2023-11-16 Isaac Friend , Aleks Kissinger