相关论文: A Knowledge Graph-based Approach for Exploring the…

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

Electronic health records (EHRs) enable strong clinical prediction, but explanations are often coarse and hard to use for patient-level decisions. We propose a knowledge graph (KG)-guided chain-of-thought (CoT) framework for visit-level…

In this paper, we present Knowledge4COVID-19, a framework that aims to showcase the power of integrating disparate sources of knowledge to discover adverse drug effects caused by drug-drug interactions among COVID-19 treatments and…

In many fields, populations of interest are hidden from data for a variety of reasons, though their magnitude remains important in determining resource allocation and appropriate policy. In public health and epidemiology, linkages or…

Drug synergy arises when the combined impact of two drugs exceeds the sum of their individual effects. While single-drug effects on cell lines are well-documented, the scarcity of data on drug synergy, considering the vast array of…

In research, measuring instruments play a crucial role in producing the data that underpin scientific discoveries. Information about instruments is essential in data interpretation and, thus, knowledge production. However, if at all…

The Covid-19 pandemic has intersected with the opioid epidemic to create a unique public health crisis, with the health and economic consequences of the virus and associated lockdowns compounding pre-existing social and economic stressors…

Identifying causative genes from patient phenotypes remains a significant challenge in precision medicine, with important implications for the diagnosis and treatment of genetic disorders. We propose a novel graph-based approach for…

The emergence of the novel COVID-19 pandemic has had a significant impact on global healthcare and the economy over the past few months. The virus's rapid widespread has led to a proliferation in biomedical research addressing the pandemic…

Real-world multi-agent systems are often dynamic and continuous, where the agents co-evolve and undergo changes in their trajectories and interactions over time. For example, the COVID-19 transmission in the U.S. can be viewed as a…

Drug use by people is on the rise and is of great interest to public health agencies and law enforcement agencies. As found by the National Survey on Drug Use and Health, 20 million Americans aged 12 years or older consumed illicit drugs in…

There is enormous growth in various fields of research. This development is accompanied by new problems. To solve these problems efficiently and in an optimized manner, algorithms are created and described by researchers in the scientific…

The "RNA world" represents a novel frontier for the study of fundamental biological processes and human diseases and is paving the way for the development of new drugs tailored to the patient's biomolecular characteristics. Although…

Pain is a complex concept that can interconnect with other concepts such as a disorder that might cause pain, a medication that might relieve pain, and so on. To fully understand the context of pain experienced by either an individual or…

The quality of a knowledge graph directly impacts the quality of downstream applications (e.g. the number of answerable questions using the graph). One ongoing challenge when building a knowledge graph is to ensure completeness and…

Despite improved digital access to scholarly literature in the last decades, the fundamental principles of scholarly communication remain unchanged and continue to be largely document-based. Scholarly knowledge remains locked in…

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

Polypharmacy, most often defined as the simultaneous consumption of five or more drugs at once, is a prevalent phenomenon in the older population. Some of these polypharmacies, deemed inappropriate, may be associated with adverse health…

In drug discovery, knowledge of the graph structure of chemical compounds is essential. Many thousands of scientific articles in chemistry and pharmaceutical sciences have investigated chemical compounds, but in cases the details of the…

We present a new unified graph-based representation of medical data, combining genetic information and medical records of patients with medical knowledge via a unique knowledge graph. This approach allows us to infer meaningful information…