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Current diagnosis and prognosis for Parkinson's disease (PD) face formidable challenges due to the heterogeneous nature of the disease course, including that (i) the impairment severity varies hugely between patients, (ii) whether a symptom…

应用统计 · 统计学 2024-10-03 Kai Kang , Yuqi Gu

The hidden Markov model (HMM) is a fundamental tool for sequence modeling that cleanly separates the hidden state from the emission structure. However, this separation makes it difficult to fit HMMs to large datasets in modern NLP, and they…

计算与语言 · 计算机科学 2020-11-10 Justin T. Chiu , Alexander M. Rush

In this study, we address the interpretability issue in complex, black-box Machine Learning models applied to sequence data. We introduce the Model-Based tree Hidden Semi-Markov Model (MOB-HSMM), an inherently interpretable model aimed at…

机器学习 · 计算机科学 2023-10-31 Chan Hsu , Wei-Chun Huang , Jun-Ting Wu , Chih-Yuan Li , Yihuang Kang

A Hidden Markov Model (HMM) is a common statistical model which is widely used for analysis of biological sequence data and other sequential phenomena. In the present paper we show how HMMs can be extended with side-constraints and present…

人工智能 · 计算机科学 2010-08-02 Henning Christiansen , Christian Theil Have , Ole Torp Lassen , Matthieu Petit

Parkinson's disease is a widespread neurodegenerative condition necessitating early diagnosis for effective intervention. This paper introduces an innovative method for diagnosing Parkinson's disease through the analysis of human EEG…

信号处理 · 电气工程与系统科学 2024-05-03 Maryam Allahbakhshi , Aylar Sadri , Seyed Omid Shahdi

Critically ill patients in regular wards are vulnerable to unanticipated adverse events which require prompt transfer to the intensive care unit (ICU). To allow for accurate prognosis of deteriorating patients, we develop a novel…

机器学习 · 计算机科学 2017-05-16 Ahmed M. Alaa , Scott Hu , Mihaela van der Schaar

Parkinson's disease (PD) is a progressive neurological disorder that impairs movement control, leading to symptoms such as tremors, stiffness, and bradykinesia. Many researchers analyzing handwriting data for PD detection typically rely on…

信号处理 · 电气工程与系统科学 2024-12-25 Jungpil Shin , Abu Saleh Musa Miah , Koki Hirooka , Md. Al Mehedi Hasan , Md. Maniruzzaman

Recent studies have proposed that one can summarize brain activity into dynamics among a relatively small number of hidden states and that such an approach is a promising tool for revealing brain function. Hidden Markov models (HMMs) are a…

神经元与认知 · 定量生物学 2021-09-02 Takahiro Ezaki , Yu Himeno , Takamitsu Watanabe , Naoki Masuda

Hypomimia is a condition in the early stages of the progression of Parkinsons disease that limits the movement of facial muscles, restricting the accurate depiction of facial expressions. Also known as facial masking, this condition is an…

医学物理 · 物理学 2021-11-25 Simoni Mishra

The stage and severity of Parkinson's disease (PD) is an important factor to consider for taking effective therapeutic decisions. Although the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) provides an…

应用统计 · 统计学 2018-05-30 R. Prashanth , Sumantra Dutta Roy

The global prevalence of diabetes, particularly type 2 diabetes mellitus (T2DM), is rapidly increasing, posing significant health and economic challenges. T2DM not only disrupts blood glucose regulation but also damages vital organs such as…

机器学习 · 计算机科学 2025-06-09 Praveen Kumar , Vincent T. Metzger , Scott A. Malec

This paper applies a hidden Markov model to the problem of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis from resting-state functional Magnetic Resonance Image (fMRI) scans of subjects. The proposed model considers the temporal…

定量方法 · 定量生物学 2015-06-22 Bhaskar Sen , Zheng Shi , Gregory Burlet

Early detection of chronic diseases is beneficial to healthcare by providing a golden opportunity for timely interventions. Although numerous prior studies have successfully used machine learning (ML) models for disease diagnoses, they…

计算机与社会 · 计算机科学 2024-10-07 Di Wang , Yidan Hu , Eng Sing Lee , Hui Hwang Teong , Ray Tian Rui Lai , Wai Han Hoi , Chunyan Miao

Actigraphy is widely used in sleep studies but lacks a universal unsupervised algorithm for sleep/wake identification. In this study, we proposed a Hidden Markov Model (HMM) based unsupervised algorithm that can automatically and…

应用统计 · 统计学 2020-04-10 Xinyue Li , Yunting Zhang , Fan Jiang , Hongyu Zhao

Motivated by disease progression-related studies, we propose an estimation method for fitting general non-homogeneous multi-state Markov models. The proposal can handle many types of multi-state processes, with several states and various…

统计方法学 · 统计学 2024-07-22 Alessia Eletti , Giampiero Marra , Rosalba Radice

We develop a latent variable model and an efficient spectral algorithm motivated by the recent emergence of very large data sets of chromatin marks from multiple human cell types. A natural model for chromatin data in one cell type is a…

机器学习 · 统计学 2015-06-09 Chicheng Zhang , Jimin Song , Kevin C Chen , Kamalika Chaudhuri

Recognizing various surgical tools, actions and phases from surgery videos is an important problem in computer vision with exciting clinical applications. Existing deep-learning-based methods for this problem either process each surgical…

计算机视觉与模式识别 · 计算机科学 2024-04-09 Haifeng Wang , Hao Xu , Jun Wang , Jian Zhou , Ke Deng

Vehicle telematics provides granular data for dynamic driving risk assessment, but current methods often rely on aggregated metrics (e.g., harsh braking counts) and do not fully exploit the rich time-series structure of telematics data. In…

应用统计 · 统计学 2025-05-28 Ian Weng Chan , Andrei L. Badescu , X. Sheldon Lin

Understanding disease progression is a central clinical challenge with direct implications for early diagnosis and personalized treatment. While recent generative approaches have attempted to model progression, key mismatches remain:…

计算机视觉与模式识别 · 计算机科学 2026-02-17 Hao Chen , Rui Yin , Yifan Chen , Qi Chen , Chao Li

In medical research, understanding changes in outcome measurements is crucial for inferring shifts in health conditions. However, traditional methods often struggle with large, irregularly longitudinal data and fail to account for the…

应用统计 · 统计学 2025-03-13 Yu Luo , Chris Sherlock