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The integration of real-world data (RWD) and randomized controlled trials (RCT) is increasingly important for advancing causal inference in scientific research. This combination holds great promise for enhancing the efficiency of causal…

统计方法学 · 统计学 2024-07-02 Xi Lin , Jens Magelund Tarp , Robin J. Evans

Randomized controlled trials (RCTs) have been the cornerstone of clinical evidence; however, their cost, duration, and restrictive eligibility criteria limit power and external validity. Studies using real-world data (RWD), historically…

统计方法学 · 统计学 2025-11-26 Shu Yang , Margaret Gamalo , Haoda Fu

The primary outcome of Randomized clinical Trials (RCTs) are typically dichotomous, continuous, multivariate continuous, or time-to-event. However, what if this outcome is unstructured, e.g., a list of variables of mixed types, longitudinal…

Exascale computing delivers the raw power to simulate ever larger and more chemically realistic systems, but realizing this potential requires codes that can efficiently use thousands of processors. Our real-space multigrid (RMG) density…

材料科学 · 物理学 2026-01-19 R. J. Morelock , S. Bagchi , E. L. Briggs , W. Lu , J. Bernholc , P. Ganesh

The demand of finite raw materials will keep increasing as they fuel modern society. Simultaneously, solutions for stopping carbon emissions in the short term are not available, thus making the net zero target extremely challenging to…

计算机与社会 · 计算机科学 2025-12-17 Federico Zocco , Andrea Corti , Monica Malvezzi

Despite the multitude of excellent software components and tools available in the robotics and broader software engineering communities, successful integration of software for robotic systems remains a time-consuming and challenging task…

机器人学 · 计算机科学 2025-09-03 Steven Swanbeck , Mitch Pryor

ROOT is an object-oriented C++ framework conceived in the high-energy physics (HEP) community, designed for storing and analyzing petabytes of data in an efficient way. Any instance of a C++ class can be stored into a ROOT file in a…

With the increased interest in computational sciences, machine learning (ML), pattern recognition (PR) and big data, governmental agencies, academia and manufacturers are overwhelmed by the constant influx of new algorithms and techniques…

软件工程 · 计算机科学 2017-07-28 André Anjos , Laurent El-Shafey , Sébastien Marcel

The profile of research software engineering has been greatly enhanced by developments at institutions around the world to form groups and communities that can support effective, sustainable development of research software. We observe,…

软件工程 · 计算机科学 2019-08-07 Jeremy Cohen , Daniel S. Katz , Michelle Barker , Robert Haines , Neil Chue Hong

Blockchains have revolutionized decentralized applications, with composability enabling atomic, trustless interactions across smart contracts. However, layer 2 (L2) scalability solutions like rollups introduce fragmentation and hinder…

密码学与安全 · 计算机科学 2025-02-10 Ioannis Kaklamanis , Fan Zhang

Many research groups aspire to make data and code FAIR and reproducible, yet struggle because the data and code life cycles are disconnected, executable environments are often missing from published work, and technical skill requirements…

We present a basic high-level structures used for developing quantum programming languages. The presented structures are commonly used in many existing quantum programming languages and we use quantum pseudo-code based on QCL quantum…

编程语言 · 计算机科学 2011-10-10 P. Gawron , J. Klamka , J. A. Miszczak , R. Winiarczyk

The reproduction and replication of research results has become a major issue for a number of scientific disciplines. In computer science and related computational disciplines such as systems biology, the challenges closely revolve around…

软件工程 · 计算机科学 2017-07-31 Tom Crick , Benjamin A. Hall , Samin Ishtiaq

Motivation: Digitization of pathology laboratories through digital slide scanners and advances in deep learning approaches for objective histological assessment have resulted in rapid progress in the field of computational pathology (CPath)…

机器学习 · 计算机科学 2022-01-31 Alex Foote , Amina Asif , Nasir Rajpoot , Fayyaz Minhas

Surveys of computational science show that many scientists use languages like C and C++ in order to write code for scientific computing, especially in scenarios where performance is a key factor. In this paper, we seek to evaluate the use…

计算物理 · 物理学 2024-10-28 Willow Veytsman , Shuang Zhai , Chen Ding , Adam B. Sefkow

FuturlCT is a FET Flagship project using collective, participatory research, integrated across ICT, the social sciences and complexity science, to design socio-inspired technology and develop a science of global, socially interactive…

适应与自组织系统 · 物理学 2012-11-13 Dirk Helbing , Steven Bishop , Paul Lukowicz , the FuturICT Consortium

Many fields of science rely on relational database management systems to analyze, publish and share data. Since RDBMS are originally designed for, and their development directions are primarily driven by, business use cases they often lack…

数据库 · 计算机科学 2013-08-08 László Dobos , Alexander S. Szalay , Tamás Budavári , István Csabai , Nolan Li

The challenges expected for the next era of the Large Hadron Collider (LHC), both in terms of storage and computing resources, provide LHC experiments with a strong motivation for evaluating ways of rethinking their computing models at many…

The proliferation of open-source scientific software for science and research presents opportunities and challenges. In this paper, we introduce the SciCat dataset -- a comprehensive collection of Free-Libre Open Source Software (FLOSS)…

软件工程 · 计算机科学 2023-12-12 Addi Malviya-Thakur , Reed Milewicz , Lavinia Paganini , Ahmed Samir Imam Mahmoud , Audris Mockus

Modern challenges arising in the fields of theoretical and experimental physics require new powerful tools for high-precision electronic structure modelling; one of the most perspective tools is the relativistic Fock space coupled cluster…

计算物理 · 物理学 2020-12-08 Alexander V. Oleynichenko , Andréi Zaitsevskii , Ephraim Eliav