相关论文: The self-tuned sensitivity of circadian clocks

Molecular circadian clocks, that are found in all nucleated cells of mammals, are known to dictate rhythms of approximately 24 hours (circa diem) to many physiological processes. This includes metabolism (e.g., temperature, hormonal blood…

This paper proposes a framework for optimising the adaptation and attunement of a Complex Adaptive System (CAS) with its environments. The tendency towards stability can be explained by minimising free energy but high variability, noise,…

Scaling analysis exploiting timescale separation has been one of the most important techniques in the quantitative analysis of nonlinear dynamical systems in mathematical and theoretical biology. In the case of enzyme catalyzed reactions,…

We study atomic systems that are in the frequency range of optical atomic clocks and have enhanced sensitivity to potential time-variation of the fine structure constant, alpha. The high sensitivity is due to coherent contributions from…

This report formulates a minimal model based on a control theoretic framework to best describe the dynamics of perfect adaptation shown by the hyper osmotic shock response system in yeast. Using principles from adaptive control and…

Microorganismal motility is often characterised by complex responses to environmental physico-chemical stimuli. Although the biological basis of these responses is often not well understood, their exploitation already promises novel avenues…

Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as well as the range of conditions and phenotypes associated…

Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain…

Microbial adaptation to extreme stress, such as starvation, antimicrobial exposure, or freezing often reveals fundamental trade-offs between survival and proliferation. Understanding how populations navigate these trade-offs in fluctuating…

Living systems process sensory data to facilitate adaptive behaviour. A given sensor can be stimulated as the result of internally driven activity, or by purely external (environmental) sources. It is clear that these inputs are processed…

Sensory neuroscience seeks to understand how the brain encodes natural environments. However, neural coding has largely been studied using simplified stimuli. In order to assess whether the brain's coding strategy depend on the stimulus…

Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often…

Microorganisms often perform chemotaxis, (i.e., sensing and moving toward a region with a higher concentration of an attractive chemical) by changing the rate of tumbling for random walk. We studied several models with internal adaptive…

At the intersection of quantum theory and relativity lies the possibility of a clock experiencing a superposition of proper times. We consider quantum clocks constructed from the internal degrees of relativistic particles that move through…

We have applied a machine learning algorithm to predict the emergence of environment-induced spontaneous synchronization between two qubits in an open system setting. In particular, we have considered three different models, encompassing…

A biophysical model of arousal dynamics is used to study mechanisms of synchronisation and loss of synchrony among the three key oscillators controlling sleep-wake cycles: the circadian, homeostatic, and light oscillators. Synchronisation…

Mechanical cues from the extracellular microenvironment play a central role in regulating the structure, function and fate of living cells. Nevertheless, the precise nature of the mechanisms and processes underlying this crucial cellular…

Circadian rhythms in living organisms are temporal orders emerging from biochemical circuits driven out of equilibrium. Here, considering the KaiABC system, a minimal model in the synthetic biology, we study how the oscillation emerges from…

Sensitivity to small changes in the environment is crucial for many real-world tasks, enabling living and artificial systems to make correct behavioral decisions. It has been shown that such sensitivity is maximized when a system operates…

Human visual perception is a complex, dynamic and fluctuating process. In addition to the incoming visual stimulus, it is affected by many other factors including temporal context, both external and internal to the observer. In this study…