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Spinal cord injury (SCI) is a debilitating condition that often results in significant motor and sensory deficits, impacting the quality of life. Current rehabilitation methods, including physical therapy and electrical stimulation, offer…

神经元与认知 · 定量生物学 2024-12-18 Ruidong Cheng , Yuling Shao , Xi Li , Li Zhang , Zehao Sheng , Chenyang Li , Xu Xie , Huilin Mou , Weidong Chen , Shaomin Zhang , Yuchen Xu , Minmin Wang

This paper addresses the question of the brain's critical dynamics after an injury such as a stroke. It is hypothesized that the healthy brain operates near a phase transition (critical point), which provides optimal conditions for…

神经元与认知 · 定量生物学 2023-08-01 Jakub Janarek , Zbigniew Drogosz , Jacek Grela , Jeremi K. Ochab , Paweł Oświęcimka

Functional connectivity (FC) between brain regions tracks symptom severity in many neuropsychiatric disorders. Transcranial magnetic stimulation (TMS) directly alters regional activity and indirectly alters FC. Predicting how FC will change…

神经元与认知 · 定量生物学 2022-08-25 Andrew C. Murphy , Romain Duprat , Theodore D. Satterthwaite , Desmond J. Oathes , Dani S. Bassett

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite "optimal"…

Deep Brain Stimulation (DBS) is an established and powerful treatment method in various neurological disorders. It involves chronically delivering electrical pulses to a certain stimulation target in the brain in order to alleviate the…

系统与控制 · 电气工程与系统科学 2023-10-03 Anna Franziska Frigge , Alexander Medvedev , Elena Jiltsova , Dag Nyholm

Since four decades ago, that the transcranial magnetic stimulation (TMS) technique was introduced, the increasing attention of neuroscience researchers and medical engineers has been focused on the development of this technique and its use…

信号处理 · 电气工程与系统科学 2022-08-31 Arsalan Heidarpanah

Transcranial static magnetic stimulation is a novel noninvasive method of reduction of the cortical excitability in certain neurological diseases that, unlike ordinary transcranial magnetic stimulation, makes use of static magnetic fields…

医学物理 · 物理学 2020-01-31 Manuel J. Freire , Joaquin Bernal-Mendez

Transcranial magnetic stimulation (TMS) is a noninvasive medical procedure that can modulate brain activity, and it is widely used in neuroscience and neurology research. Compared to manual operators, robots may improve the outcome of TMS…

Background: Spinal cord injury (SCI) rehabilitation remains a major clinical challenge, with limited treatment options for functional recovery. Temporal interference (TI) electrical stimulation has emerged as a promising non-invasive…

医学物理 · 物理学 2025-03-07 Xu Xie , Yuchen Xu , Huilin Mou , Xi Li , Li Zhang , Zehao Sheng , Weidong Chen , Shaomin Zhang , Ruidong Cheng , Minmin Wang

Background: The brain's functional network constantly adapts to external changes. However, the mechanisms underlying this dynamic adaptive behavior in stroke patients with motor injuries and its role in post-stroke motor recovery remain…

神经元与认知 · 定量生物学 2024-01-18 Kaichao Wu , Beth Jelfs , Katrina Neville , Qiang Fang

Deep Brain Stimulation (DBS) is a well-established neurosurgical treatment aiming at symptom alleviation in a range of neurological and psychiatric diseases. Computational models of DBS are widely used to investigate the effects of…

系统与控制 · 电气工程与系统科学 2025-11-17 Anna Franziska Frigge , Alexander Medvedev

Many studies have shown that the dorsolateral prefrontal cortex (DLPFC) plays an important role in top-down cognitive control over intentional and deliberate behavior. However, recent studies have reported that DLPFC-mediated top-down…

神经元与认知 · 定量生物学 2019-02-18 Mario Rosero Pahi , Juliana Cavalli , Frauke Nees , Herta Flor , Jamila Andoh

Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…

神经元与认知 · 定量生物学 2021-04-26 Shivakeshavan Ratnadurai-Giridharan , Chung Cheung , Leonid Rubchinsky

Background and Objective: Transcranial temporal interference stimulation (tTIS) is a promising non-invasive brain stimulation technique in which interference between electrical current fields extends the possibilities of electrical brain…

数值分析 · 数学 2026-02-05 Santtu Söderholm , Maryam Samavaki , Sampsa Pursiainen

Deep brain stimulation (DBS) is an effective therapy as an alternative to pharmaceutical treatments for Parkinson's disease (PD). Aside from factors such as instrumentation, treatment plans, and surgical protocols, the success of the…

图像与视频处理 · 电气工程与系统科学 2024-10-30 Yiming Xiao , Jonathan C. Lau , Dimuthu Hemachandra , Greydon Gilmore , Ali R. Khan , Terry M. Peters

Deep Brain Stimulation (DBS) is a therapy widely used for treating the symptoms of neurological disorders. Electrical pulses are chronically delivered in DBS to a disease-specific brain target via a surgically implanted electrode. The…

系统与控制 · 电气工程与系统科学 2024-10-24 Anna Franziska Frigge , Elena Jiltsova , Fredrik Olsson , Dag Nyholm , Alexander Medvedev

One of the central problems in neuroscience is reconstructing synaptic connectivity in neural circuits. Synapses onto a neuron can be probed by sequentially stimulating potentially pre-synaptic neurons while monitoring the membrane voltage…

神经元与认知 · 定量生物学 2012-10-05 Tao Hu , Dmitri B. Chklovskii

Currently, strokes are the leading cause of adult disability in the United States. Traditional treatment and rehabilitation options such as physical therapy and tissue plasminogen activator are limited in their effectiveness and ability to…

信号处理 · 电气工程与系统科学 2020-08-20 Mohammad-Parsa Hosseini , Cecilia Hemingway , Jerard Madamba , Alexander McKee , Natalie Ploof , Jennifer Schuman , Elliot Voss

We present a real-time visualization system for Transcranial Magnetic Stimulation (TMS), a non-invasive neuromodulation technique for treating various brain disorders and mental health diseases. Our solution targets the current challenges…

信号处理 · 电气工程与系统科学 2024-03-14 Loraine Franke , Tae Young Park , Jie Luo , Yogesh Rathi , Steve Pieper , Lipeng Ning , Daniel Haehn

Stroke is a leading cause of neurological injury characterized by impairments in multiple neurological domains including cognition, language, sensory and motor functions. Clinical recovery in these domains is tracked using a wide range of…

定量方法 · 定量生物学 2021-10-01 Sanjukta Krishnagopal , Keith Lohse , Robynne Braun