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Estimating treatment effects is crucial for personalized decision-making in medicine, but this task faces unique challenges in clinical practice. At training time, models for estimating treatment effects are typically trained on…

机器学习 · 计算机科学 2025-10-31 Yuchen Ma , Dennis Frauen , Jonas Schweisthal , Stefan Feuerriegel

Dose-finding clinical trials in oncology aim to estimate the maximum tolerated dose (MTD), based on safety traditionally obtained from the clinician's perspective. While the collection of patient-reported outcomes (PROs) has been advocated…

应用统计 · 统计学 2023-04-03 Anaïs Andrillon , Lucie Biard , Shing M. Lee

Vision-language models (VLMs) such as CLIP exhibit strong Out-of-distribution (OOD) detection capabilities by aligning visual and textual representations. Recent CLIP-based test-time adaptation methods further improve detection performance…

计算与语言 · 计算机科学 2026-04-20 Jinlun Ye , Jiang Liao , Runhe Lai , Xinhua Lu , Jiaxin Zhuang , Zhiyong Gan , Ruixuan Wang

Large language models (LLMs) have emerged as promising tools for assisting in medical tasks, yet processing Electronic Health Records (EHRs) presents unique challenges due to their longitudinal nature. While LLMs' capabilities to perform…

人工智能 · 计算机科学 2025-03-07 Hejie Cui , Alyssa Unell , Bowen Chen , Jason Alan Fries , Emily Alsentzer , Sanmi Koyejo , Nigam Shah

Recent advances in large language models have led to renewed interest in natural language processing in healthcare using the free text of clinical notes. One distinguishing characteristic of clinical notes is their long time span over…

计算与语言 · 计算机科学 2023-07-17 Hongyi Zheng , Yixin Zhu , Lavender Yao Jiang , Kyunghyun Cho , Eric Karl Oermann

In traditional dose-finding studies, dose-limiting toxicity (DLT) is determined within a fixed time observation window where DLT is often defined as a binary outcome. In the setting of oncology dose-finding trials, often patients in…

应用统计 · 统计学 2019-09-09 Lucie Biard , Bin Cheng , Gulam A. Manji , Shing M. Lee

This article presents our steps to integrate complex and partly unstructured medical data into a clinical research database with subsequent decision support. Our main application is an integrated faceted search tool, accompanied by the…

人机交互 · 计算机科学 2018-10-31 Daniel Sonntag , Hans-Jürgen Profitlich

Objective: Clinical notes contain information not present elsewhere, including drug response and symptoms, all of which are highly important when predicting key outcomes in acute care patients. We propose the automatic annotation of…

计算与语言 · 计算机科学 2021-11-25 Jingqing Zhang , Luis Bolanos , Ashwani Tanwar , Julia Ive , Vibhor Gupta , Yike Guo

Clinical notes contain unstructured text provided by clinicians during patient encounters. These notes are usually accompanied by a sequence of diagnostic codes following the International Classification of Diseases (ICD). Correctly…

机器学习 · 计算机科学 2025-10-17 Mohammad Mansoori , Amira Soliman , Farzaneh Etminani

Cancer stage classification is important for making treatment and care management plans for oncology patients. Information on staging is often included in unstructured form in clinical, pathology, radiology and other free-text reports in…

计算与语言 · 计算机科学 2024-09-04 Chia-Hsuan Chang , Mary M. Lucas , Grace Lu-Yao , Christopher C. Yang

Tumor Treating Fields (TTFields) is an FDA approved treatment for specific types of cancer and significantly extends patients life. The intensity of the TTFields within the tumor was associated with the treatment outcomes: the larger the…

计算机视觉与模式识别 · 计算机科学 2020-10-07 Reuben R Shamir , Zeev Bomzon

Retrieval-augmented learning based on radiology reports has emerged as a promising direction to improve performance on long-tail medical imaging tasks, such as rare disease detection in chest X-rays. Most existing methods rely on comparing…

机器学习 · 计算机科学 2025-08-28 Felix Nützel , Mischa Dombrowski , Bernhard Kainz

BACKGROUND: Radiology reports are typically written in a free-text format, making clinical information difficult to extract and use. Recently the adoption of structured reporting (SR) has been recommended by various medical societies thanks…

This study aimed to utilize text processing and natural language processing (NLP) models to mine clinical notes for the diagnosis of periodontitis and to evaluate the performance of a named entity recognition (NER) model on different…

Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep…

机器学习 · 计算机科学 2019-11-13 Justin R. Lovelace , Nathan C. Hurley , Adrian D. Haimovich , Bobak J. Mortazavi

Radiotherapy (RT) is a key component in the treatment of various cancers, including Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML). Precise delineation of organs at risk (OARs) and target areas is essential for…

计算机视觉与模式识别 · 计算机科学 2023-11-14 Ricardo Coimbra Brioso , Damiano Dei , Ciro Franzese , Nicola Lambri , Daniele Loiacono , Pietro Mancosu , Marta Scorsetti

Radiotherapy represents an important phase of treatment for a large number of cancer patients. It is essential that resources used to deliver this treatment are employed effectively. This paper presents a new integer linear programming…

计算工程、金融与科学 · 计算机科学 2011-03-18 Edmund K. Burke , Pedro Leite-Rocha , Sanja Petrovic

The current medical standard for setting an oral cancer (OC) diagnosis is histological examination of a tissue sample from the oral cavity. This process is time consuming and more invasive than an alternative approach of acquiring a brush…

图像与视频处理 · 电气工程与系统科学 2022-02-07 Nadezhda Koriakina , Nataša Sladoje , Vladimir Bašić , Joakim Lindblad

Extraction of relevant pathological terms from radiology reports is important for correct image label generation and disease population studies. In this letter, we compare the performance of some known application program interface (APIs)…

信息检索 · 计算机科学 2018-12-08 Tahsin Mostafiz , Khalid Ashraf

Extra-label drug use in food animal medicine is authorized by the US Animal Medicinal Drug Use Clarification Act (AMDUCA), and estimated withdrawal intervals are based on published scientific pharmacokinetic data. Occasionally there is a…