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Clustering cancer patients into subgroups and identifying cancer subtypes is an important task in cancer genomics. Clustering based on comprehensive multi-omic molecular profiling can often achieve better results than those using a single…

基因组学 · 定量生物学 2017-08-25 Tianle Ma , Aidong Zhang

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of…

机器学习 · 计算机科学 2023-12-06 Mark Peelen , Leila Bagheriye , Johan Kwisthout

While deep learning has achieved great success in computer vision and many other fields, currently it does not work very well on patient genomic data with the "big p, small N" problem (i.e., a relatively small number of samples with…

机器学习 · 计算机科学 2018-09-07 Tianle Ma , Aidong Zhang

Cancer is a highly heterogeneous disease with significant variability in molecular features and clinical outcomes, making diagnosis and treatment challenging. In recent years, high-throughput omic technologies have facilitated the discovery…

定量方法 · 定量生物学 2024-08-19 Saiful Islam , Md. Nahid Hasan

In the realm of precision medicine, effective patient stratification and disease subtyping demand innovative methodologies tailored for multi-omics data. Clustering techniques applied to multi-omics data have become instrumental in…

机器学习 · 计算机科学 2024-01-30 Bastian Pfeifer , Christel Sirocchi , Marcus D. Bloice , Markus Kreuzthaler , Martin Urschler

The analysis of cancer omics data is a "classic" problem, however, still remains challenging. Advancing from early studies that are mostly focused on a single type of cancer, some recent studies have analyzed data on multiple "related"…

统计方法学 · 统计学 2022-12-01 Yifan Sun , Yu Jiang , Yang Li , Shuangge Ma

Cancer is responsible for millions of deaths worldwide every year. Although significant progress has been achieved in cancer medicine, many issues remain to be addressed for improving cancer therapy. Appropriate cancer patient…

机器学习 · 计算机科学 2021-03-31 David Oniani , Chen Wang , Yiqing Zhao , Andrew Wen , Hongfang Liu , Feichen Shen

Leukemia diagnosis and monitoring rely increasingly on high-throughput image data, yet conventional clustering methods lack the flexibility to accommodate evolving cellular patterns and quantify uncertainty in real time. We introduce…

机器学习 · 计算机科学 2025-12-01 Marco Aruta , Ciro Listone , Giuseppe Murano , Aniello Murano

Background. Breast cancer comprises at least five molecular subtypes with distinct prognoses, yet PAM50 classification relies on transcriptomics alone. Whether integrating DNA methylation and copy number data improves subtype recovery and…

基因组学 · 定量生物学 2026-03-03 Taha Ahmad

Cancer is a number of related yet highly heterogeneous diseases. Correct identification of cancer subtypes is critical for clinical decisions. The advance in sequencing technologies has made it possible to study cancer based on abundant…

应用统计 · 统计学 2018-11-27 Xiaochun Chen , Honggang Wang , Donghui Yan

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…

机器学习 · 计算机科学 2024-07-29 Asim Waqas , Aakash Tripathi , Ravi P. Ramachandran , Paul Stewart , Ghulam Rasool

Cancer, with its inherent heterogeneity, is commonly categorized into distinct subtypes based on unique traits, cellular origins, and molecular markers specific to each type. However, current studies primarily rely on complete multi-omics…

机器学习 · 计算机科学 2024-11-26 Yingxuan Ren , Fengtao Ren , Bo Yang

Identifying robust and accurate correspondences across images is a fundamental problem in computer vision that enables various downstream tasks. Recent semi-dense matching methods emphasize the effectiveness of fusing relevant cross-view…

计算机视觉与模式识别 · 计算机科学 2024-05-24 Hongkai Chen , Zixin Luo , Yurun Tian , Xuyang Bai , Ziyu Wang , Lei Zhou , Mingmin Zhen , Tian Fang , David McKinnon , Yanghai Tsin , Long Quan

Network biology has been successfully used to help reveal complex mechanisms of disease, especially cancer. On the other hand, network biology requires in-depth knowledge to construct disease-specific networks, but our current knowledge is…

计算机视觉与模式识别 · 计算机科学 2018-06-18 Sungmin Rhee , Seokjun Seo , Sun Kim

Federated learning (FL) is a distributed learning method that offers medical institutes the prospect of collaboration in a global model while preserving the privacy of their patients. Although most medical centers conduct similar medical…

机器学习 · 计算机科学 2022-07-08 Yousef Yeganeh , Azade Farshad , Johann Boschmann , Richard Gaus , Maximilian Frantzen , Nassir Navab

Multimodal medical imaging provides complementary information that is crucial for accurate delineation of pathology, but the development of deep learning models is limited by the scarcity of large datasets in which different modalities are…

计算机视觉与模式识别 · 计算机科学 2025-12-29 Arunkumar V , Firos V M , Senthilkumar S , Gangadharan G R

Personalized decision-making can be implemented in a Federated learning (FL) framework that can collaboratively train a decision model by extracting knowledge across intelligent clients, e.g. smartphones or enterprises. FL can mitigate the…

机器学习 · 计算机科学 2023-02-01 Guodong Long , Ming Xie , Tao Shen , Tianyi Zhou , Xianzhi Wang , Jing Jiang , Chengqi Zhang

Client heterogeneity poses significant challenges to the performance of Quantum Federated Learning (QFL). To overcome these limitations, we propose a new approach leveraging deep unfolding, which enables clients to autonomously optimize…

机器学习 · 计算机科学 2025-06-26 Shanika Iroshi Nanayakkara , Shiva Raj Pokhrel

Oral cancer is frequently diagnosed at later stages due to its similarity to other lesions. Existing research on computer aided diagnosis has made progress using deep learning; however, most approaches remain limited by small, imbalanced…

计算机视觉与模式识别 · 计算机科学 2026-01-06 Joy Naoum , Revana Salama , Ali Hamdi

Operators from various industries have been pushing the adoption of wireless sensing nodes for industrial monitoring, and such efforts have produced sizeable condition monitoring datasets that can be used to build diagnosis algorithms…

机器学习 · 计算机科学 2023-04-27 Hao Lu , Adam Thelen , Olga Fink , Chao Hu , Simon Laflamme
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