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We investigate the problem of calibration and assessment of predictive rules in prognostic designs when missing values are present in the predictors. Our paper has two key objectives which are entwined. The first is to investigate how the…

统计方法学 · 统计学 2018-10-12 B. J. A. Mertens , E. Banzato , L. C. de Wreede

Multiple imputation provides us with efficient estimators in model-based methods for handling missing data under the true model. It is also well-understood that design-based estimators are robust methods that do not require accurately…

统计方法学 · 统计学 2020-06-11 Kyunghee Han , Pamela A. Shaw , Thomas Lumley

Missing data imputation, where a model is trained on observed data to estimate unobserved values, is a fundamental problem in machine learning. In this paper, we rigorously formulate imputation model learning as a mean-squared error risk…

机器学习 · 统计学 2026-05-14 Luke Shannon , Song Liu , Katarzyna Reluga

Routinely collected nation-wide registers contain socio-economic and health-related information from a large number of individuals. However, important information on lifestyle, biological and other risk factors is available at most for…

统计方法学 · 统计学 2024-09-23 Tommi Härkänen , Sangita Kulathinal , Arya Panthalanickal Vijayakumar

When data are missing due to at most one cause from some time to next time, we can make sampling distribution inferences about the parameter of the data by modeling the missing-data mechanism correctly. Proverbially, in case its mechanism…

统计方法学 · 统计学 2014-07-21 Kosuke Morikawa , Yutaka Kano

Large-scale population-based studies in medicine are a key resource towards better diagnosis, monitoring, and treatment of diseases. They also serve as enablers of clinical decision support systems, in particular Computer Aided Diagnosis…

机器学习 · 计算机科学 2022-03-01 Gerome Vivar , Anees Kazi , Hendrik Burwinkel , Andreas Zwergal , Nassir Navab , Seyed-Ahmad Ahmadi

Missing data is a common problem in clinical data collection, which causes difficulty in the statistical analysis of such data. In this article, we consider the problem under a framework of a semiparametric partially linear model when…

统计方法学 · 统计学 2022-06-13 Zishu Zhan , Xiangjie Li , Jingxiao Zhang

Survey data collection often is plagued by unit and item nonresponse. To reduce reliance on strong assumptions about the missingness mechanisms, statisticians can use information about population marginal distributions known, for example,…

统计方法学 · 统计学 2024-06-10 Yanjiao Yang , Jerome P. Reiter

Missing Not At Random (MNAR) values lead to significant biases in the data, since the probability of missingness depends on the unobserved values.They are ''not ignorable'' in the sense that they often require defining a model for the…

统计理论 · 数学 2020-06-11 Aude Sportisse , Claire Boyer , Julie Josse

Methods to handle missing data have been extensively explored in the context of estimation and descriptive studies, with multiple imputation being the most widely used method in clinical research. However, in the context of clinical risk…

统计方法学 · 统计学 2024-11-25 Junhui Mi , Rahul D. Tendulkar , Sarah M. C. Sittenfeld , Sujata Patil , Emily C. Zabor

Clinical decision support using data mining techniques offers more intelligent way to reduce the decision error in the last few years. However, clinical datasets often suffer from high missingness, which adversely impacts the quality of…

机器学习 · 计算机科学 2020-11-20 Xuetong Wu , Hadi Akbarzadeh Khorshidi , Uwe Aickelin , Zobaida Edib , Michelle Peate

Missing observations are common in cluster randomised trials. Approaches taken to handling such missing data include: complete case analysis, single-level multiple imputation that ignores the clustering, multiple imputation with a fixed…

统计方法学 · 统计学 2014-07-18 Karla Diaz-Ordaz , Michael G. Kenward , Manuel Gomes , Richard Grieve

Multiple imputation (MI) is an established technique to handle missing data in observational studies. Joint modeling (JM) and fully conditional specification (FCS) are commonly used methods for imputing multilevel clustered data. However,…

统计方法学 · 统计学 2022-09-28 Mei Dong , Aya Mitani

Missing data arises when certain values are not recorded or observed for variables of interest. However, most of the statistical theory assume complete data availability. To address incomplete databases, one approach is to fill the gaps…

统计方法学 · 统计学 2023-08-15 Luis Alejandro Masmela-Caita , Thais Paiva Galletti , Marcos Oliveira Prates

Model-based unsupervised learning, as any learning task, stalls as soon as missing data occurs. This is even more true when the missing data are informative, or said missing not at random (MNAR). In this paper, we propose model-based…

Missing data is inevitable in longitudinal clinical trials. Conventionally, the missing at random assumption is assumed to handle missingness, which however is unverifiable empirically. Thus, sensitivity analysis is critically important to…

统计方法学 · 统计学 2022-03-18 Siyi Liu , Shu Yang , Yilong Zhang , Guanghan , Liu

Federated learning allows for the training of machine learning models on multiple decentralized local datasets without requiring explicit data exchange. However, data pre-processing, including strategies for handling missing data, remains a…

Multiple data sources are becoming increasingly available for statistical analyses in the era of big data. As an important example in finite-population inference, we consider an imputation approach to combining a probability sample with big…

统计方法学 · 统计学 2018-07-10 Shu Yang , Jae Kwang Kim

This paper provides clear and practical guidance on the specification of imputation models when multiple imputation is used in conjunction with doubly robust estimation methods for causal inference. Through theoretical arguments and…

统计方法学 · 统计学 2025-12-19 Lucy D'Agostino McGowan

When using multiple imputation (MI) for missing data, maintaining compatibility between the imputation model and substantive analysis is important for avoiding bias. For example, some causal inference methods incorporate an outcome model…