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Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often…

Data imputation, the process of filling in missing feature elements for incomplete data sets, plays a crucial role in data-driven learning. A fundamental belief is that data imputation is helpful for learning performance, and it follows…

机器学习 · 计算机科学 2025-09-30 Ruikai Yang , Fan He , Mingzhen He , Kaijie Wang , Xiaolin Huang

Item nonresponse is frequently encountered in practice. Ignoring missing data can lose efficiency and lead to misleading inference. Fractional imputation is a frequentist approach of imputation for handling missing data. However, the…

统计方法学 · 统计学 2018-09-18 Hejian Sang , Jae Kwang Kim

Handling missing data in time series is a complex problem due to the presence of temporal dependence. General-purpose imputation methods, while widely used, often distort key statistical properties of the data, such as variance and…

统计方法学 · 统计学 2026-03-18 Guilherme Pumi , Taiane Schaedler Prass , Douglas Krauthein Verdum

Imputation of missing attribute values in medical datasets for extracting hidden knowledge from medical datasets is an interesting research topic of interest which is very challenging. One cannot eliminate missing values in medical records.…

数据库 · 计算机科学 2016-03-11 Yelipe UshaRani , P. Sammulal

We introduce a new multiple type I error criterion for clinical trials with multiple populations. Such trials are of interest in precision medicine where the goal is to develop treatments that are targeted to specific sub-populations…

统计方法学 · 统计学 2021-02-05 Werner Brannath , Charlie Hillner , Kornelius Rohmeyer

Valid statistical inference is challenging when the sample is subject to unknown selection bias. Data integration can be used to correct for selection bias when we have a parallel probability sample from the same population with some common…

统计方法学 · 统计学 2023-07-24 Zhonglei Wang , Shu Yang , Jae Kwang Kim

Multivariate density estimation is a popular technique in statistics with wide applications including regression models allowing for heteroskedasticity in conditional variances. The estimation problems become more challenging when…

统计方法学 · 统计学 2018-08-15 Zhen Li , Lili Wu , Weilian Zhou , Sujit Ghosh

Use of prediction models is widely recommended by clinical guidelines, but usually requires complete information on all predictors that is not always available in daily practice. We describe two methods for real-time handling of missing…

Conducting valid statistical analyses is challenging in the presence of missing-not-at-random (MNAR) data, where the missingness mechanism is dependent on the missing values themselves even conditioned on the observed data. Here, we…

统计方法学 · 统计学 2023-06-13 Anna Guo , Jiwei Zhao , Razieh Nabi

Can humans impute missing data with similar proficiency as machines? This is the question we aim to answer in this paper. We present a novel idea of converting observations with missing data in to a survey questionnaire, which is presented…

机器学习 · 计算机科学 2018-02-26 Lovedeep Gondara

Multiple Imputation (MI) is one of the most popular approaches to addressing missing values in questionnaires and surveys. MI with multivariate imputation by chained equations (MICE) allows flexible imputation of many types of data. In…

统计方法学 · 统计学 2023-04-24 Edoardo Costantini , Kyle M. Lang , Klaas Sijtsma , Tim Reeskens

Baseline covariates in randomized experiments are often used in the estimation of treatment effects, for example, when estimating treatment effects within covariate-defined subgroups. In practice, however, covariate values may be missing…

统计方法学 · 统计学 2023-08-29 Gauri Kamat , Jerome P. Reiter

When fitting a generalized linear model -- such as a linear regression, a logistic regression, or a hierarchical linear model -- analysts often wonder how to handle missing values of the dependent variable Y. If missing values have been…

统计方法学 · 统计学 2017-03-27 Paul T. von Hippel

Current domain adaptation methods under missingness shift are restricted to Missing At Random (MAR) missingness mechanisms. However, in many real-world examples, the MAR assumption may be too restrictive. When covariates are Missing Not At…

统计方法学 · 统计学 2025-04-02 Tyrel Stokes , Hyungrok Do , Saul Blecker , Rumi Chunara , Samrachana Adhikari

Missing data is unavoidable in longitudinal clinical trials, and outcomes are not always normally distributed. In the presence of outliers or heavy-tailed distributions, the conventional multiple imputation with the mixed model with…

统计方法学 · 统计学 2022-03-22 Siyi Liu , Yilong Zhang , Gregory T Golm , Guanghan , Liu , Shu Yang

Design-based causal inference, also known as randomization-based or finite-population causal inference, is one of the most widely used causal inference frameworks, largely due to the merit that its validity can be guaranteed by study design…

统计方法学 · 统计学 2025-05-27 Siyu Heng , Jiawei Zhang , Yang Feng

Missing data are a common problem for both the construction and implementation of a prediction algorithm. Pattern mixture kernel submodels (PMKS) - a series of submodels for every missing data pattern that are fit using only data from that…

统计方法学 · 统计学 2017-04-27 Sarah Fletcher Mercaldo , Jeffrey D. Blume

Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science. In…

应用统计 · 统计学 2019-01-03 Qingyuan Zhao , Jingshu Wang , Gibran Hemani , Jack Bowden , Dylan S. Small

We consider logistic regression including two sets of discrete or categorical covariates that are missing at random (MAR) separately or simultaneously. We examine the asymptotic properties of two multiple imputation (MI) estimators, given…

统计方法学 · 统计学 2023-12-19 Phuoc-Loc Tran , Shen-Ming Lee , Truong-Nhat Le , Chin-Shang Li