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Stochastic fluctuations of molecule numbers are ubiquitous in biological systems. Important examples include gene expression and enzymatic processes in living cells. Such systems are typically modelled as chemical reaction networks whose…

定量方法 · 定量生物学 2017-01-13 David Schnoerr , Guido Sanguinetti , Ramon Grima

Boolean network models of strongly connected modules are capable of capturing the high regulatory complexity of many biological gene regulatory circuits. We study numerically the previously introduced basin entropy, a parameter for the…

无序系统与神经网络 · 物理学 2009-11-13 P. Krawitz , I. Shmulevich

The rate of entropy production by a stochastic process quantifies how far it is from thermodynamic equilibrium. Equivalently, entropy production captures the degree to which detailed balance and time-reversal symmetry are broken. Despite…

统计力学 · 物理学 2020-12-02 Luca Cocconi , Rosalba Garcia-Millan , Zigan Zhen , Bianca Buturca , Gunnar Pruessner

We define the concept of dependence among multiple variables using maximum entropy techniques and introduce a graphical notation to denote the dependencies. Direct inference of information theoretic quantities from data uncovers…

定量方法 · 定量生物学 2007-07-13 Ilya Nemenman

This paper deals with the asymptotic behavior and FEM error analysis of a class of strongly damped wave equations using a semidiscrete finite element method in spatial directions combined with a finite difference scheme in the time…

数值分析 · 数学 2025-11-03 Krishan Kumar , P. Danumjaya , Anil Kumar , Amiya K. Pani

Understanding the non-equilibrium dynamics of extended quantum systems after the trigger of a sudden, global perturbation (quench) represents a daunting challenge, especially in the presence of interactions. The main difficulties stem from…

强关联电子 · 物理学 2009-11-13 Alexandre Faribault , Pasquale Calabrese , Jean-Sebastien Caux

Exponential random graph models (ERGMs) are a widely used framework for network data, enabling hypothesis testing on the structural mechanisms underlying observed networks. Bayesian ERGMs provide principled uncertainty quantification and…

统计方法学 · 统计学 2026-05-26 Alberto Caimo , Isabella Gollini

Problems of probabilistic inference and decision making under uncertainty commonly involve continuous random variables. Often these are discretized to a few points, to simplify assessments and computations. An alternative approximation is…

人工智能 · 计算机科学 2013-03-08 William B. Poland , Ross D. Shachter

We investigate a Poisson-Nernst-Planck type system in three spatial dimensions where the strength of the electric drift depends on a possibly small parameter and the particles are assumed to diffuse quadratically. On grounds of the global…

偏微分方程分析 · 数学 2015-10-23 Jonathan Zinsl

In this paper, we consider diagonal hyperbolic systems with monotone continuous initial data. We propose a natural semi-explicit and upwind first order scheme. Under a certain non-negativity condition on the Jacobian matrix of the…

数值分析 · 数学 2016-12-01 Laurent Monasse , Régis Monneau

Bayesian inference for exponential family random graph models (ERGMs) is a doubly-intractable problem because of the intractability of both the likelihood and posterior normalizing factor. Auxiliary variable based Markov Chain Monte Carlo…

统计计算 · 统计学 2020-07-15 Fan Yin , Carter T. Butts

We consider the problem of estimating a probability distribution that maximizes the entropy while satisfying a finite number of moment constraints, possibly corrupted by noise. Based on duality of convex programming, we present a novel…

最优化与控制 · 数学 2019-10-22 Tobias Sutter , David Sutter , Peyman Mohajerin Esfahani , John Lygeros

We report multipronged progress on the stochastic averaging approach to numerical analytic continuation of quantum Monte Carlo data. With the sampled spectrum parametrized with delta-functions in continuous frequency space, a calculation of…

强关联电子 · 物理学 2023-01-11 Hui Shao , Anders W. Sandvik

We consider a model system consisting of two reaction-diffusion equations, where one species diffuses in a volume while the other species diffuses on the surface which surrounds the volume. The two equations are coupled via a nonlinear…

偏微分方程分析 · 数学 2017-07-21 Tang Quoc Bao , Klemens Fellner , Evangelos Latos

We study the exponential stability of evolutionary equations. The focus is laid on second order problems and we provide a way to rewrite them as a suitable first order evolutionary equation, for which the stability can be proved by using…

偏微分方程分析 · 数学 2015-05-11 Sascha Trostorff

Systems with long-range interactions display a short-time relaxation towards Quasi Stationary States (QSS) whose lifetime increases with the system size. In the paradigmatic Hamiltonian Mean-field Model (HMF) out-of-equilibrium phase…

统计力学 · 物理学 2016-02-15 Gabriele Martelloni , Gianluca Martelloni , Pierre de Buyl , Duccio Fanelli

We consider a damped linear hyperbolic system modelling the propagation of pressure waves in a network of pipes. Well-posedness is established via semi-group theory and the existence of a unique steady state is proven in the absence of…

数值分析 · 数学 2016-05-11 Herbert Egger , Thomas Kugler

We characterize different cell states, related to cancer and ageing phenotypes, by a measure of entropy of network ensembles, integrating gene expression values and protein interaction networks. The entropy measure estimates the parameter…

分子网络 · 定量生物学 2013-05-24 G. Menichetti , G. Bianconi , E. Giampieri , G. Castellani , D. Remondini

Aussel et al. (J Optim Theory Appl 170 818-837 2016) introduced the concept of projected solutions for the quasi-variational inequalities with a non-self constraint map, that is, the case where the constraint map may take values outside the…

最优化与控制 · 数学 2025-06-30 Didier Aussel , Jauny , Asrifa Sultana , Shivani Valecha

We consider the one-dimensional $XX$-model in a quasi-periodic transverse-field described by the Harper potential, which is equivalent to a tight-binding model of spinless fermions with a quasi-periodic chemical potential. For weak…

无序系统与神经网络 · 物理学 2014-11-26 Gergö Roósz , Uma Divakaran , Heiko Rieger , Ferenc Iglói